Cannabis and Cannabinoid Research

Adolescent cannabinoid vapour exposure sex-dependently alters the relationship between vulnerability traits and ethanol self-administration and modifies naltrexone actions on ethanol intake in rats

This study examines how adolescent cannabinoid exposure affects ethanol self-administration and naltrexone efficacy in rats, revealing sex-dependent changes in ethanol consumption patterns and response to naltrexone.

Cannabinoid Receptor 2 Activating Antibodies: A Promising Therapeutic Strategy for Macrophage-Driven Fibro-Inflammatory Diseases

This paper introduces two novel CB2-specific agonist antibodies that reduce macrophage activation and fibrosis in vitro and an ex vivo liver model.

Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation

This study investigates whether inhaled CBD pretreatment inhibits GBM growth in mice, finding that 14-day pretreatment reduces tumor growth and modulates the immune microenvironment.

Effects of oral cannabidiol (CBD) on spontaneous opioid withdrawal in male and female rats

This study tests if oral CBD reduces opioid withdrawal symptoms in rats, finding no significant effect on physical or anxiety-like withdrawal symptoms.

Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain

This study shows that CBD reduces oxycodone self-administration in rats with neuropathic pain without diminishing oxycodone's pain-relieving effects.

Dual Transcriptomic and Epigenomic Signatures of THC Exposure in Human Prefrontal Cortex Development

This study uses human iPSC-derived prefrontal cortex organoids to show that THC exposure disrupts neurodevelopmental gene expression and epigenetic regulation, linking these changes to autism risk genes.

Longer chronic cannabis use in humans is associated with impaired implicit motor learning and supranormal resting state cortical activity

Repeated administration of cannabidiol decreases splenic lymphocyte numbers in rats: involvement of CB2 receptors

This study shows that repeated CBD administration in rats reduces splenic lymphocyte numbers via CB2 receptors, similar to its effects in peripheral blood.

Inhibition of fatty acid amide hydrolase (FAAH) by URB597 counteracts cognitive deficit and alters neuroendocrine stress responses in male and female rats

This study shows that FAAH inhibition by URB597 improves memory and alters stress hormone levels differently in male and female rats.

(S)-ketamine augments behavioral and physiological responses to Δ9-tetrahydrocannabinol

This study investigates the combined effects of (S)-ketamine and THC on behavior and physiology in mice, finding that ketamine enhances THC-induced hypothermia and motor impairments.

Altered network function in hippocampus after sub-chronic activation of Cannabis receptors in peri-adolescence

This study shows that adolescent exposure to a CB1R agonist leads to lasting theta rhythm abnormalities in adulthood, with greater effects when exposure occurs during early adolescence.

Differences in the co-distribution of the Cannabinoid Receptor-1, FAAH, and MAGL in the human and mouse brain could be limiting clinical translation of endocannabinoid outcomes in mouse models of Alzheimer disease.

The paper compares the distribution of CB1R, FAAH, and MAGL in human and mouse AD brains, finding species-specific differences that may affect the translatability of ECS findings in mouse models.

Activation of cannabinoid receptor CB1 leads to aberrant myelination in development

This study shows that activating CB1 receptors in zebrafish leads to increased non-axonal ensheathment without affecting OL differentiation or normal myelin formation.

Protective role of Cannabidiol against nicotine pouch-induced seizure aggravation and alterations in brain glymphatic biomarkers.

This study shows that chronic nicotine pouch exposure worsens seizures and glymphatic function in mice, but inhaled CBD reverses these effects.

Cannabidiol Reduces D1 and D2 Medium Spiny Neuron Excitability in the Nucleus Accumbens Core

This study shows that CBD reduces excitability of D1 and D2 medium spiny neurons in the nucleus accumbens core without affecting excitatory synaptic transmission.

Spatially resolved mapping of monoacylglycerol lipase activity in the brain

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats

This study examines THC vapor self-administration in rats, finding that pre-exposure to THC increases intake and that females show higher responding under certain conditions.

The Contribution of Circulating Endocannabinoid Tone to Individual Differences in Human Pain Sensitivity: A Quantitative Sensory Testing Study

This study investigates the relationship between the endocannabinoid system and pain sensitivity in humans using quantitative sensory testing, finding no significant associations overall but a specific link between FAAH substrates and pressure pain thresholds.

Impaired synaptic inhibition and enhanced aversion encoding by lateral habenula neurons during Δ9-tetrahydrocannabinol withdrawal.

This study shows that Δ9-THC withdrawal increases LHb responsivity to aversive stimuli through impaired synaptic inhibition and altered E-I balance.

Insights into Cannabinoid Receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning

This study investigates how CB2 receptor ligands influence anterograde trafficking and subcellular distribution, revealing their role as pharmacological chaperones.

Effects of the Neutral CB1 Receptor Antagonist AM6527 on Spontaneous, Consummatory, and Motivated Behavior in Mice

This study examines the behavioral effects of the neutral CB1R antagonist AM6527 in mice, finding dose-dependent reductions in reward consumption and motivated behavior, with partial dopaminergic rescue.

Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system

This study shows that an obesogenic diet impairs memory consolidation in mice via the hippocampal endocannabinoid system and mTOR pathway, which can be reversed by CB1R blockade or mTOR inhibition.

Cannabidiol (CBD) as a novel inhibitor of HLA-G expression in human choriocarcinoma cell line (JEG-3)

This study shows CBD and CBD-HCE reduce HLA-G expression in JEG-3 cells, suggesting a potential immunomodulatory role in cancer therapy.

Mice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward

This study investigates the role of NAPE-PLD in opioid responsiveness and finds sex-dependent differences in oxycodone and sucrose consumption in knockout mice.

Cannabivarin and Tetrahydrocannabivarin Modulate Nociception via Vanilloid Channels and Cannabinoid-Like Receptors in Caenorhabditis elegans

This study investigates the antinociceptive effects of CBV and THCV in C. elegans, showing dose-dependent effects and involvement of vanilloid and cannabinoid pathways.

Prenatal Cannabinoids Produce Sex Specific Changes in Risk Assessment and Shared Increases in Repetitive Behavior in Adult Offspring

This study shows prenatal exposure to CBD or THC alters adult offspring behavior differently by sex, with CBD increasing female risk assessment and both increasing repetitive behavior.

Proof of Concept for High-Dose Cannabidiol Pretreatment to Antagonize Opioid Induced Persistent Apnea

This study shows high-dose CBD pretreatment reduces opioid-induced persistent apnea in mice, as effective as naloxone, suggesting a new approach to prevent opioid overdose deaths.

Sex-specific disruptions in the developmental trajectory of anxiety due to prenatal cannabidiol exposure

This study shows prenatal CBD exposure causes sex-specific anxiety disruptions in mice, with females showing persistent anxiety-like behaviors and altered reward responsiveness.

Individual differences in the pharmacokinetic profiling of {triangleup}9-THC may be associated with differential motivational effects of {triangleup}9-THC on cognitive performance.

The study examines how stress and THC affect working memory in rats, finding that high THC doses disrupt motivation in some animals, linked to higher THC concentrations.

THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury?

This study shows THC protects astrocytes from HIV Tat-induced senescence and inflammation in rhesus macaques, but high-dose THC may harm glial survival.