Iron Metabolism and Disorders

Modeling the iron storage protein ferritin reveals how residual ferrihydrite iron determines initial ferritin iron sequestration kinetics

The paper develops a computational model of ferritin iron sequestration kinetics, validated against experimental data, showing FT concentration and saturation impact sequestration dynamics.

The global prevalence and ethnic heterogeneity of iron-refractory iron deficiency anaemia

This study estimates the global carrier frequency and genetic prevalence of IRIDA using gnomAD data, finding a higher prevalence than previously thought.

Physiopathological changes of ferritin mRNA density and distribution in hippocampal astrocytes in the mouse brain

The paper examines ferritin mRNA density and distribution in hippocampal astrocytes under different iron overload conditions and finds changes in mRNA ratios and localization.

Biallelic STAB1 pathogenic variants cause hereditary hyperferritinemia

The paper identifies biallelic STAB1 mutations as a genetic cause of inherited hyperferritinemia without iron overload.

Impact of maternal iron deficiency anaemia on fetal iron status and placental iron transporters in human pregnancy

The paper examines how maternal iron deficiency anaemia affects placental iron transporters and fetal iron status in human pregnancy, finding increased expression of DMT1 and FPN1 in placenta under maternal iron insufficiency.

ATAC and histone H3K9me3 landscapes revealed the altered epigenome by fetal-neonatal iron deficiency in the adult male rat hippocampus

This study examines how fetal-neonatal iron deficiency and prenatal choline supplementation affect epigenetic marks in adult rat hippocampi, revealing altered chromatin accessibility and H3K9me3 enrichment linked to gene dysregulation.

Penetrance of HFE haemochromatosis variants to clinical disease: polygenic risk score associations in UK Biobank

This study shows that polygenic risk scores for iron levels and related diseases increase the risk of clinical outcomes in HFE p.C282Y homozygotes, but not in females or compound heterozygotes.

Functional disruption of Transferrin expression alters reproductive physiologyin Anopheles culicifacies

This paper characterizes a transferrin homolog in Anopheles culicifacies, showing its role in iron transport and reproductive physiology through expression analysis and RNAi experiments.

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

BBB damage in aging causes brain iron deposits via astrocyte-neuron crosstalk and Hepc/Fpn1 pathway

The paper shows that BBB damage in aging leads to brain iron deposits through astrocyte-neuron interactions and the Hepc/Fpn1 pathway.

Iatrogenic Iron Promotes Neurodegeneration and Activates Self-protection of Neural Cells against Exogenous Iron Attacks

This study investigates the impact of iron from metal implants on neural cells, finding that iron accumulation affects neuronal function and may increase neurodegeneration risk.

Control of Systemic Iron Homeostasis by the 3' Iron-Responsive Element of Divalent Metal Transporter 1 in Mice.

This study shows that the 3' IRE of DMT1 regulates iron homeostasis in mice, promoting intestinal DMT1 expression in early life and suppressing it in adulthood.

Astrocytes express DMT1 and transferrin receptors, which transport iron thus activating Ca2+ signalling: possible role in neuroprotection against iron overload?

This study investigates how iron ions affect calcium signaling in astrocytes through DMT1 and TFR, revealing mechanisms of neuroprotection against iron overload.

Fetal liver hepcidin supports acquisition of iron stores in utero

This study investigates the role of fetal liver hepcidin in iron store acquisition, finding that fetal liver HAMP acts cell-autonomously to increase iron stores, unlike in adults.

Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer's disease

The paper identifies IRE-containing genes and shows their expression changes are early markers of Alzheimer's disease in zebrafish, revealing species-specific differences in IRE transcript stability under iron dyshomeostasis.

Relevance of the iron-responsive element (IRE) pseudotriloop structure for IRP1/2 binding and validation of IRE-like structures using the yeast three-hybrid system

This study uses the yeast three-hybrid system to analyze the structural requirements of IREs for IRP1/2 binding and validates IRE-like structures from different genes.

Iron deficiency affects early stages of embryonic hematopoiesis but not the endothelial to hematopoietic transition

The paper investigates the impact of iron deficiency on embryonic hematopoiesis, finding it affects hematopoietic progenitor survival and proliferation but not the endothelial to hematopoietic transition.

A rare variant on a common risk haplotype of HFE causes increased risk of hereditary hemochromatosis

The paper identifies HFE E168Q as a novel pathogenic variant associated with hereditary hemochromatosis using Phenotype Risk Scores and validates its mechanism through experimental assays.

A computational model to understand mouse iron physiology and diseases

This paper develops a mathematical model of iron distribution in mice to simulate iron-related diseases and interventions.

Brain Iron Mediates the Relationship Between Cognition and Neighborhood Socioeconomic Status in Youth

The paper investigates how brain iron levels in youth relate to cognitive performance and socioeconomic status, hypothesizing that higher iron in basal ganglia regions mediates this relationship.

Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient

The paper develops a computational model of iron distribution in mice to test if hepcidin alone can regulate iron homeostasis under different dietary conditions, finding it insufficient in high iron diets.