Iron Metabolism and Disorders

Additive associations of variants at the expression quantitative trait loci of TFR2 and EPO in a linkage disequilibrium block with hypochromic erythropoiesis

The paper identifies genetic variants associated with erythrocyte traits and iron metabolism in a Japanese population, revealing a linkage disequilibrium block linked to hypochromic erythropoiesis.

Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment

This study investigates the uptake and metabolic fate of two iron-carbohydrate complexes in macrophages, revealing distinct intracellular behaviors that affect their therapeutic outcomes.

Liposomal iron bisglycinate hydrochloride, but not free iron bisglycinate, enhances serum iron restoration in a mouse model of inflammation-induced anemia

This study compares liposomal iron bisglycinate hydrochloride (LIBH) and free iron bisglycinate hydrochloride (FIBH) in restoring serum iron levels in a mouse model of inflammation-induced anemia, finding LIBH more effective.

Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression

The paper shows that mitochondrial iron transport via MFRN1 is essential for erythroid cell cycle progression and terminal differentiation.

Storage and transport of labile iron is mediated by lysosomes in axons and dendrites of hippocampal neurons

This study shows that labile Fe(II) is stored in lysosomes and transported along axons and dendrites in hippocampal neurons, with a method to quantify its distribution.

Cell-type specific iron content regulation revealed by single-cell iron quantification

The paper quantifies cellular iron content in immune cells using sc-ICP-MS and finds cell-type and activation state-specific iron regulation.

Iron deficiency drives metabolic adaptation of red pulp macrophages via ferroportin-SYK signaling and BCAA catabolism to enhance erythrophagocytosis

FAM210B regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis

This study shows FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis, with defects in spleen size and blood cell counts in knockout mice.

Crucial role for iron metabolism in mediating influenza A virus infection and associated disease

This study shows that iron metabolism influences influenza A virus infection and disease by altering gene expression, increasing viral titer, and worsening inflammation, with TFR1 inhibition offering protection.

Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis

This study compares the effects of dietary iron deprivation and supplementation in a murine colitis model, finding both worsen inflammation and gut dysbiosis compared to adequate iron diets.

Profile of proteins involved in iron homeostasis and energy metabolism in multiple organs of leptin-deficient mice

This study examines protein changes in iron homeostasis and energy metabolism across multiple organs in leptin-deficient mice, revealing tissue-specific disruptions in iron and metabolic regulation with age.

Development of a Genetically Encoded Live-Cell Iron Mapping System

The paper develops two genetically encoded fluorescent iron reporter systems to monitor cellular iron status in live cells, showing cell-to-cell variation in response to iron treatments.

Influencing Iron Homeostasis by Transition Metal Complexes Interacting with a messenger-RNA Stem Loop in the Iron Regulating Element

The paper shows that tris bipyridine iron complexes interact with the IRE RNA stem-loop, affecting ferritin translation and iron homeostasis.

Enterobactin carries iron into C. elegans and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1

This study shows that enterobactin delivers iron into C. elegans and mammalian cells independently of DMT1, supporting its role in iron homeostasis and potential therapeutic use.

Discordance between biomarkers of iron status in plasma and myocardium across iron replete, iron deficiency, and iron replacement states.

The paper compares plasma and myocardial iron status measures in mice and humans, finding discordance between plasma biomarkers and myocardial iron levels across different iron states.

Iron-sensitive RNA regulation by poly C binding proteins

The paper identifies iron-sensitive RNA regulation by poly C binding proteins through transcriptome analysis under low iron conditions.

Exploring the link between extended red blood cell parameters and platelet indices in voluntary blood donors

This study investigates the relationship between extended red blood cell parameters and platelet indices in blood donors, finding that certain parameters can effectively detect iron deficiency and its association with thrombocytosis.

A novel mechanism for the uptake of enterobactin-chelated ferric ions by the mitochondria and subsequent reduction to ferrous ions inside

The paper proposes a novel mechanism where Fe(III) chelated by enterobactin enters mitochondria and is reduced to Fe(II) inside, challenging conventional views of mitochondrial iron uptake.

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

Associations between sex, systemic iron and inflammatory status and subcortical brain iron

This study examines sex differences in associations between systemic iron, inflammation markers, and subcortical brain iron levels in older adults.

Insights into the role of glycerophospholipids on the iron export function of SLC40A1 and the molecular mechanisms of ferroportin disease.

The paper investigates how glycerophospholipids influence SLC40A1 conformational changes and identifies key residues linked to ferroportin disease.

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.

A new form of hereditary iron overload unlinked to known hereditary haemochromatosis genes

The paper describes a new hereditary iron overload condition in a family unlinked to known genes like HFE and SLC40A1, with linkage to multiple chromosomes.

Cellular Iron Deficiency Disrupts Thyroid Hormone Regulated Gene Expression in Developing Hippocampal Neurons

This study shows neuronal iron deficiency disrupts thyroid hormone-regulated gene expression in developing hippocampal neurons, with some effects persisting after iron repletion.

Characterization of erythroferrone oligomerization and its impact on BMP antagonism

This study investigates how erythroferrone (ERFE) oligomerization affects its ability to inhibit BMP ligands, identifying a critical ligand binding domain essential for BMP antagonism.

Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

The Genetic Architecture of Dietary Iron Overload and Associated Pathology in Mice

This study investigates the genetic basis of dietary iron overload and associated pathologies in mice using the Hybrid Mouse Diversity Panel, identifying genetic loci and pathways involved.

Serum iron variation is circadian-regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic Tfrc expression in mice.

This study shows serum iron, hepatic Tfrc expression, and erythropoietic activity exhibit circadian rhythms in mice, with opposing phases to optimize iron usage and storage.

Autolysis affects the iron cargo of ferritins in neurons and glial cells at different rates in the human brain

The paper examines how autolysis affects iron storage in ferritins of neurons and glial cells in the human brain, showing differential iron loss rates and cell-type-specific ferritin accumulation.

Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome

This study examines sex-specific transcriptome changes in adult rat hippocampus due to early-life iron deficiency and prenatal choline treatment, finding greater effects in females.