Iron Metabolism and Disorders

Canonical Notch2 Signaling Regulates the Development of Iron-recycling Macrophages and Iron Homeostasis

Iron homeostasis and reproduction: Unveiling the Microbiome-Gut-Brain-Axis connection in the mosquito Anopheles culicifacies

This study investigates how iron homeostasis affects the microbiome-Gut-Brain-Axis (mGBA) communication and reproductive success in Anopheles culicifacies mosquitoes.

An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters

This study investigates the role of an N-terminal amphipathic helix in Nramp transporters, showing it regulates conformational dynamics and metal ion transport.

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

Disruption of Iron Metabolism Resulting from Dmt1/Slc11A2 Deficiency Compromises Notch Protein Degradation and Transcriptional Activation

This study shows that Dmt1 deficiency disrupts iron homeostasis, leading to lysosomal dysfunction and impaired Notch signaling by affecting NICD1 degradation and transcriptional activation.

A multi-omic approach reveals iron availability influences cell fate fidelity

The paper shows that iron availability affects hepatocyte identity in HepG2 cells by modulating HNF4A-driven transcription.

Osteocyte-derived erythroferrone regulates liver hepcidin during stress erythropoiesis

The paper identifies osteocytes as a source of erythroferrone (Erfe) that suppresses liver hepcidin during stress erythropoiesis.

SYSTEMIC FRATAXIN DEFICIENCY CAUSES TISSUE-DEPENDENT IRON HOMEOSTASIS ALTERATIONS: IMPLICATIONS FOR FRIEDREICH ATAXIA

This study shows that frataxin deficiency causes tissue-specific iron homeostasis changes in FXNI151F mice, with brain iron overload and cardiac iron deficiency responses.

High Glucose Diet Induces Hepatic Iron Overload Contributing to Metabolic Dysfunction

This study shows that a high glucose diet causes hepatic iron overload in mice, disrupting iron regulation and contributing to metabolic dysfunction, with potential therapeutic implications for iron chelation and metformin use.

Ironing out the role of Nrf2 in cardiac iron metabolism during myocardial infarction

This study investigates how Nrf2 disruption affects iron metabolism in myocardial infarction by examining its role in the Nrf2/hepcidin/ferroportin axis and ferritinophagy in cardiac cells.

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment

This study investigates the uptake and metabolic fate of two iron-carbohydrate complexes in macrophages, revealing distinct intracellular behaviors that affect their therapeutic outcomes.

Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression

The paper shows that mitochondrial iron transport via MFRN1 is essential for erythroid cell cycle progression and terminal differentiation.

Storage and transport of labile iron is mediated by lysosomes in axons and dendrites of hippocampal neurons

This study shows that labile Fe(II) is stored in lysosomes and transported along axons and dendrites in hippocampal neurons, with a method to quantify its distribution.

FAM210B regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis

This study shows FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis, with defects in spleen size and blood cell counts in knockout mice.

Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis

This study compares the effects of dietary iron deprivation and supplementation in a murine colitis model, finding both worsen inflammation and gut dysbiosis compared to adequate iron diets.

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

Associations between sex, systemic iron and inflammatory status and subcortical brain iron

This study examines sex differences in associations between systemic iron, inflammation markers, and subcortical brain iron levels in older adults.

Insights into the role of glycerophospholipids on the iron export function of SLC40A1 and the molecular mechanisms of ferroportin disease.

The paper investigates how glycerophospholipids influence SLC40A1 conformational changes and identifies key residues linked to ferroportin disease.

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.

Cellular Iron Deficiency Disrupts Thyroid Hormone Regulated Gene Expression in Developing Hippocampal Neurons

This study shows neuronal iron deficiency disrupts thyroid hormone-regulated gene expression in developing hippocampal neurons, with some effects persisting after iron repletion.

Characterization of erythroferrone oligomerization and its impact on BMP antagonism

This study investigates how erythroferrone (ERFE) oligomerization affects its ability to inhibit BMP ligands, identifying a critical ligand binding domain essential for BMP antagonism.

Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

Autolysis affects the iron cargo of ferritins in neurons and glial cells at different rates in the human brain

The paper examines how autolysis affects iron storage in ferritins of neurons and glial cells in the human brain, showing differential iron loss rates and cell-type-specific ferritin accumulation.

Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome

This study examines sex-specific transcriptome changes in adult rat hippocampus due to early-life iron deficiency and prenatal choline treatment, finding greater effects in females.

Modeling the iron storage protein ferritin reveals how residual ferrihydrite iron determines initial ferritin iron sequestration kinetics

The paper develops a computational model of ferritin iron sequestration kinetics, validated against experimental data, showing FT concentration and saturation impact sequestration dynamics.

The global prevalence and ethnic heterogeneity of iron-refractory iron deficiency anaemia

This study estimates the global carrier frequency and genetic prevalence of IRIDA using gnomAD data, finding a higher prevalence than previously thought.

Physiopathological changes of ferritin mRNA density and distribution in hippocampal astrocytes in the mouse brain

The paper examines ferritin mRNA density and distribution in hippocampal astrocytes under different iron overload conditions and finds changes in mRNA ratios and localization.

Functional disruption of Transferrin expression alters reproductive physiologyin Anopheles culicifacies

This paper characterizes a transferrin homolog in Anopheles culicifacies, showing its role in iron transport and reproductive physiology through expression analysis and RNAi experiments.

Iatrogenic Iron Promotes Neurodegeneration and Activates Self-protection of Neural Cells against Exogenous Iron Attacks

This study investigates the impact of iron from metal implants on neural cells, finding that iron accumulation affects neuronal function and may increase neurodegeneration risk.