Bariatric Surgery and Outcomes

Vertical Sleeve Gastrectomy inhibits 11βHSD1 and subsequently reduces IL6 secretion in Mice and Humans: A Shared Anti-Inflammatory Mechanism

This study shows that vertical sleeve gastrectomy reduces 11βHSD1 and IL6 in mice and humans, linking glucocorticoid metabolism to improved glucose homeostasis and reduced inflammation.

Gastric resection and restriction yield distinct neuroendocrine and metabolic outcomes in obese mice

This study compares the metabolic and neuroendocrine effects of sleeve gastrectomy (SG) and gastric plication (GP) in obese mice, finding distinct outcomes despite similar weight loss.

Adipose Tissue Pericellular Fibrosis, Weight Loss and Features of Metabolic Dysfunction-Associated Steatotic Liver Disease after Bariatric Surgery

This study examines changes in adipose tissue fibrosis and ECM components in response to bariatric surgery and their association with weight loss and MASLD features.

NEURAL CORRELATES OF SUBJECTIVE FOOD VALUATION IN THE CONTEXT OF BARIATRIC SURGERY

This study examines how bariatric surgery affects neural valuation of food stimuli over time and links these changes to long-term weight loss outcomes.

Additional effects of bariatric surgery and metformin on glucose regulation in non-obese insulin-deficient diabetic rats

This study examines how bariatric surgery and metformin affect glucose regulation in diabetic rats, finding that their combination improves postprandial glucose control without enhancing insulin sensitivity or hormone secretion.

Sleeve gastrectomy protects lean mice from future obesity.

This study shows that sleeve gastrectomy in lean mice improves metabolic health and protects against future obesity without weight loss.

A low protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

Vertical sleeve gastrectomy in rodents: impact on metabolic, cardiovascular and hepatic functions of mothers and perinatal consequences

This study examines the effects of sleeve gastrectomy on maternal metabolic, cardiovascular, and hepatic functions and perinatal outcomes in rodents.

Vitamin D receptor is necessary for metabolic health after sleeve gastrectomy

This study shows that the vitamin D receptor is essential for metabolic health after sleeve gastrectomy in mice, affecting insulin sensitivity, white adipose tissue function, and inflammation, with similar findings in human patients.

Alterations in glucocorticoid homeostasis following sleeve gastrectomy

This study shows that sleeve gastrectomy reduces circulating active/inactive glucocorticoid ratios and improves glucose tolerance in mice by increasing renal HSD11B2 activity.

Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery

This study uses longitudinal single-cell adipose transcriptomics to identify genes and variants associated with weight loss after bariatric surgery and shows that BMI polygenic risk scores predict weight loss outcomes.

Cholesterol Metabolism in a Murine Model of Vertical Sleeve Gastrectomy

This study shows that vertical sleeve gastrectomy in mice reduces plasma cholesterol without weight loss by enhancing bile acid synthesis and hepatobiliary elimination.

Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks

This study investigates genetic factors influencing weight loss from GLP1-RA and bariatric surgery in 10,960 individuals across 9 biobanks, finding no strong genetic associations with GLP1-RA effectiveness but a modest link between BMI polygenic scores and reduced bariatric surgery weight loss.

Intestinal epithelial adaptations to vertical sleeve gastrectomy defined at single-cell resolution

This study uses single-cell transcriptomics to analyze how vertical sleeve gastrectomy affects intestinal epithelial cell types and pathways in mice, identifying gene and pathway changes related to metabolic improvements.

Effect of sleeve gastrectomy on sperm quality and fertility on non-obese diabetes diet model rat

This study examines how sleeve gastrectomy affects sperm quality, hormonal profiles, and testis tissue in type II diabetes mellitus rats, finding improvements in testosterone, sperm count, and testis tissue.

DISRUPTION OF SYMPATHETIC OUTFLOW TO INTRA-ABDOMINAL ORGANS EMULATES THE METABOLIC EFFECTS OF SLEEVE GASTRECTOMY IN OBESE MICE

This study shows that sleeve gastrectomy (SG) causes degeneration of sympathetic neurons in the celiac-superior mesenteric ganglia (CSMG), which mediates metabolic effects like weight loss and glycemic improvement.

Single-cell Chromatin Accessibility and Lipid Profiling Reveals a Metabolic Shift in Adipocytes Induced by Bariatric Surgery

This study uses single-cell ATAC sequencing and lipid profiling to show that bariatric surgery alters chromatin accessibility and fatty acid profiles in adipose tissue, suggesting a metabolic shift mediated by Scd1.

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

The paper identifies mediators of improved glycemia after gastric bypass surgery using a high-throughput mediation analysis method applied to plasma proteome and metabolome data.

Type 2 Diabetes Modifies Skeletal Muscle Gene Expression Response to Gastric Bypass Surgery

This study examines how type 2 diabetes affects skeletal muscle gene expression changes after gastric bypass surgery, finding that many diabetes-related gene downregulations normalize one year post-surgery.

Twelve-year changes in protein profiles in patients with and without gastric bypass surgery

The paper measures 12-year changes in blood-circulating proteins in patients with and without gastric bypass surgery, finding long-term associations with BMI and lipid levels.

Neuroanatomical Changes in White and Grey Matter after Sleeve Gastrectomy

This study examines brain structural changes after sleeve gastrectomy, finding increased grey and white matter density associated with weight loss and metabolic improvement.

Metabolic and Hormonal Alterations Induced by Roux-en-Y Gastric Bypass

This study profiles the metabolome of obese patients after RYGB surgery and links changes to hormonal and cytokine levels, identifying associations between leptin, IL-6, and microbial metabolites.