Neurogenesis and neuroplasticity mechanisms

This study shows that Ascl1 induces low-efficiency neuronal reprogramming of proliferative glia in vivo, unlike its efficient in vitro conversion.

This study shows miR-17~92 has different effects on neural stem cells and transit amplifying cells in the adult mouse V-SVZ, affecting proliferation and lineage commitment.

This study shows human bone marrow-derived mesenchymal cells can transdifferentiate into neural-like cells without cell fusion, forming binucleated cells through nuclear movement.

This study compares phenotypes of Pax6 mutant cerebral organoids with Pax6 mutant mouse embryos, finding similarities in neural differentiation and cell cycle changes.

This paper investigates the anatomical development of the cerebello-thalamic tract in embryonic mice, showing that axons invade the thalamus after E16.5 and establish synapses by E18.5.

This study characterizes the transcriptomic and cellular dynamics of whole CNS regeneration in the tunicate Polycarpa mytiligera, identifying key pathways and markers involved in the process.

The paper investigates learning-related changes in grey matter and myelin in rodent sensorimotor cortex using MRI and immunohistochemistry, finding non-linear morphometric changes linked to myelin plasticity.

The paper uses live-imaging to show that squid retinal neurogenesis shares vertebrate-like mechanisms, including interkinetic nuclear migration and Notch signaling regulation.

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

The paper shows that GABA levels in the adult mouse spinal cord regulate neural stem cell proliferation, with increased GABA reducing proliferation and decreased GABA increasing it.

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

The paper investigates MYT1L's role in suppressing earlier neuronal development programs in the adult mouse brain, showing it regulates gene expression and chromatin structure in cortical neurons.

The paper identifies SHH signaling from retinal ganglion cells to thalamic astrocytes as essential for GABAergic interneuron migration into the visual thalamus.

This study identifies Tensin3 as a critical regulator of oligodendrocyte differentiation by mediating integrin-β1 survival signaling during morphological changes.

This study develops a method to generate cortico-striatal organoids from single neural rosettes to model SHANK3 deficiency in autism and intellectual disability.

This study shows that β-CATENIN is essential for organizing fimbrial glia and guiding dentate gyrus development, but not for CR cell positioning.

The paper shows that learning induces dynamic changes in myelination on specific axons, altering conduction speed and correlating with behavioral improvement.

This study shows that transplanting fetal GABAergic progenitors into mice with temporal lobe epilepsy reduces seizure frequency by correcting abnormalities in adult neurogenesis.

This study shows that lesion environments direct transplanted neural progenitors to differentiate into neuroprotective astroglial cells in CNS injuries.

The paper shows apical progenitors in the developing neocortex have heterogeneous apical surface areas, and Ephrin B1 regulates this size without affecting proliferation or differentiation.

This study identifies VAMP2/3-mediated exocytosis as essential for CNS myelin membrane expansion, revealing a pathway critical for myelin formation and potential therapeutic targeting.

This study shows that DHCR7 deficiency leads to oxysterol accumulation, causing premature neurogenesis and neuronal localization issues in SLOS, with GR as a potential therapeutic target.

This study shows that CHD8 haploinsufficiency in human neural progenitors shortens the G1 phase of the cell cycle, leading to increased proliferation and potential macrocephaly in autism.

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

The paper identifies species-specific transposon-derived enhancers contributing to transcriptomic differences in human and chimpanzee hippocampal intermediate progenitors.

This study determines the developmental timeline of the mouse claustrum, including neuronal birthdates, spatial localization, and the maturation of its cortical projections.

The paper shows that hippocampal network dynamics in adult mice are shaped by the birthdate and rate of neurogenesis during embryonic development.

The paper investigates neuroblast migration in porcine brain development, focusing on their association with cellular substrates during key developmental stages.

This study shows that reducing PTBP1 in astrocytes does not convert them into neurons or improve Alzheimer's symptoms in mouse models.