Neurological disorders and treatments

In vivo electrophysiological validation of DREADD-based inhibition of pallidal neurons in the non-human primate.

The paper validates DREADD-based inhibition of pallidal neurons in non-human primates using electrophysiological recordings and histochemical analysis.

Neural Selectivity, Efficiency, and Dose Equivalence in Deep Brain Stimulation through Pulse Width Tuning and Segmented Electrodes.

This study investigates how pulse width tuning and segmented electrodes affect deep brain stimulation, finding that long pulse widths reduce side effects and improve battery efficiency.

Left prefrontal impact links subthalamic stimulation with depressive symptoms

This study links left prefrontal connectivity with worsening depressive symptoms after STN-DBS in Parkinson's Disease.

Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations.

This study uses numerical simulations to show that STN firing rates drive beta oscillations, while GPe firing rates and spike bursting have state-dependent effects on beta band oscillations in the STN-GPe network.

Phase dependence of response curves to stimulation and their relationship: from a Wilson-Cowan model to essential tremor patient data

The paper uses a Wilson-Cowan model to analyze phase-dependent effects of deep brain stimulation in essential tremor patients, showing the model can predict tremor responses and fit patient data.

The Role of the Subthalamic Nucleus in Inhibitory Control of Oculomotor Behavior in Parkinson’s Disease

This study investigates the role of subthalamic nucleus (STN) deep brain stimulation (DBS) in anti-saccade behavior in Parkinson’s disease patients, finding STN DBS increases error rates and interacts with dopamine therapy.

TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models

This study shows that increasing torsinB levels can reduce abnormal movements and neurodegeneration in DYT1 dystonia mouse models caused by torsinA loss-of-function.

Lipid metabolic stress in development defines which genetically-susceptible DYT-TOR1A mice develop disease

The paper shows that genetic susceptibility to DYT-TOR1A dystonia in mice depends on developmental lipid metabolic stress, which is influenced by sex and maternal diet.

Whole exome sequencing identifies novel DYT1 dystonia-associated genome variants as potential disease modifiers

The paper identifies novel genome variants associated with DYT1 dystonia through whole exome sequencing and suggests they may modify disease penetrance.

Cortico-basal-ganglia communication: Temporally structured activity for selective motor control

The paper examines cortico-basal-ganglia communication in Parkinson's patients, finding that gamma phase coupling between STN spikes and cortical activity precedes fast reaction times and is modulated by movement direction.

Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

The paper examines frontal theta and beta oscillations in Parkinson’s disease patients during lower-limb movement, finding correlations between these oscillations and motor symptoms.

Structural integrity following focused ultrasound thalamotomy and its correlation with tremor relief

This study evaluates white matter integrity changes after focused ultrasound thalamotomy and links them to tremor relief in patients with essential tremor and Parkinson's disease.

Unsupervised Clustering Reveals Spatially Varying Single Neuronal Firing Patterns in the Subthalamic Nucleus of Patients with Parkinson's Disease

This study uses unsupervised clustering to identify distinct neuronal firing patterns in the subthalamic nucleus of Parkinson's disease patients and finds spatial differences in firing activity.

Acute cerebellar knockdown of Sgce reproduces salient features of Myoclonus-dystonia (DYT11) in mice

This study uses acute cerebellar knockdown of Sgce in mice to replicate key features of DYT11, including dystonia and ethanol-responsive myoclonus.

Cognitive Improvements after Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s disease; a Preliminary Approach

This study compares intermittent and continuous deep brain stimulation of the nucleus basalis of Meynert in a transgenic rat model of Alzheimer’s disease, finding that intermittent stimulation improves spatial memory performance.

Localization of immunoreactive, dystonia-associated protein torsinA near the Golgi apparatus of cultured rodent astrocytes

The paper shows that overexpressed torsinA proteins in astrocytes follow a mis-localization model, but endogenous torsinA is localized near the Golgi, suggesting caution in interpreting overexpression studies.

Localization of the signal of dystonia-associated protein torsinA near the Golgi apparatus in cultured central neurons

The paper localizes torsinA protein near the Golgi apparatus in cultured mouse neurons, contrasting previous overexpression studies.

Npas1+-Nkx2.1+ Neurons Form A Unique Pallidal Neuron Subclass

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.

ApproXON: Heuristic Approximation to the E-Field-Threshold for Deep Brain Stimulation Volume-of-Tissue-Activated Estimation

The paper introduces a heuristic approximation method for estimating the volume-of-tissue-activated in deep brain stimulation using pulse width and axon diameter as predictors.

Motor cortex can directly drive the globus pallidal neurons in a projection neuron type dependent manner in rat

This study shows that motor cortex directly connects to globus pallidal neurons in rats, with differential projections based on cortical area and neuron type.

Mapping short-latency cortical responses to electrical stimulation of thalamic motor nuclei by increasing sampling rate - a technical report

The paper reports on mapping short-latency cortical responses to electrical stimulation of the ventral anterior thalamic nucleus using increased sampling rates.

Autonomous oscillations and phase-locking in a biophysically detailed model of the STN-GPe network

This study uses a biophysically detailed model to show how intrinsic and exogenous beta-band oscillations interact in the STN-GPe network to produce pathological synchronization in Parkinson's disease.

Transcriptome profiles in brains of mice heterozygous for a DYT1 dystonia-associated mutation in the endogenous Tor1a gene

The paper examines transcriptome profiles in mouse brain regions with a DYT1 dystonia mutation, finding subtle genotype-dependent changes across regions but not within individual regions.

Low frequency oscillatory activity of the subthalamic nucleus is a predictive biomarker of compulsive-like cocaine seeking.

The paper identifies low frequency STN oscillations as a biomarker predicting compulsive-like cocaine seeking in rodents and shows DBS can modulate this behavior.

Association of SYNE2 variants in accelerating the progress of DYT1 early-onset isolated dystonia

The paper identifies SYNE2 variants associated with earlier onset of DYT1 dystonia by affecting TOR1A-SYNE2 protein interactions in a family with TOR1A mutations.

A Computational Model of Thalamic Tonic-burst Motor Projection Neurons and Their Regulation by Pallidal GABAergic Neurons

The paper develops a computational model of thalamic neurons regulated by pallidal GABAergic inputs, showing how GPi firing patterns control Vop burst spiking.

Direct Pathway Neurons in Mouse Dorsolateral Striatum In Vivo Receive Stronger Synaptic Input than Indirect Pathway Neurons

The paper compares synaptic input strength between direct and indirect pathway neurons in the striatum of mice, finding direct pathway neurons receive stronger input, which is lost in dopamine-depleted mice.

Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease

This study examines how subthalamic deep brain stimulation (STN-DBS) affects impulsivity and subjective uncertainty estimates in Parkinson’s disease patients through gambling behavior analysis.

Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in Parkinsonian mice

The paper investigates abnormal network dynamics in the GPe-STN circuit of Parkinsonian mice and identifies key changes in neuronal activity and connectivity.

Cerebellar Purkinje cell microcircuits are essential for tremor

This study shows that Purkinje cell activity is essential for tremor, as silencing it blocks tremor in mice and modulating it with deep brain stimulation reduces tremor.