Sleep and Wakefulness Research

Sleep and wakefulness in rats: probabilities of state transitions and state-to-state serial correlations in relation to circadian and ultradian phases

This study analyzes sleep-wake state transitions in rats, finding no support for sleep homeostasis hypotheses and proposing an alternative mechanism based on transition momentum.

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness

The paper investigates the relationship between locus coeruleus (LC) activity during wakefulness and REM sleep quality in humans, finding task-dependent associations.

Homeostatic Forces Shaping the Daily Pattern of Sleep Propensity.

The paper models daily sleep propensity using a wave model of homeostatic regulation, showing how wake-state instability and interaction strength between sleep and wake states produce a bimodal pattern.

Precisely phase-locked acoustic stimuli globally enhance slow oscillations, but depress fast spindles

This study shows that precisely phase-locked acoustic stimuli increase slow oscillations and delta power globally, but decrease fast spindles both short and long term during sleep.

Pupil size reveals arousal level dynamics in human sleep

This study uses pupil size measurements during sleep to explore arousal level dynamics and their relationship with sleep oscillations and auditory responses.

Distinct forms of amyloid-β moderate sleep duration through NAD+-linked redox metabolism in Alzheimer's disease.

The paper links amyloid-β forms to sleep duration changes in Alzheimer's disease via NAD+-linked redox metabolism using Drosophila models and human data.

Neurometabolic signaling and control of policy complexity

The paper investigates how hypothalamic hypocretin/orexin neurons regulate decision policy complexity through metabolic and neural signaling mechanisms in mice.

Heart Rate Variability During Rapid Eye Movement Sleep is Associated with Reduced Negative Memory Bias

This study investigates how heart rate variability during REM sleep influences emotional memory consolidation, finding that REM vagal HRV promotes a positive memory bias.

Sleep resolves competition between explicit exemplar memory and implicit memory generalization

The paper shows sleep resolves competition between explicit and implicit memory components and improves generalization of knowledge.

Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice

This study identifies complement and coagulation pathway activation as a mechanism by which chronic sleep restriction accelerates brain aging in mice.

The individual determinants of morning dream recall

This study identifies factors influencing morning dream recall in adults, finding associations with attitude towards dreaming, mind wandering, sleep patterns, age, and interference vulnerability.

Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors-1 and -2 shapes dopaminergic cell activity and socio-emotional behavior

This study investigates the distinct roles of OX1R and OX2R in modulating dopaminergic neuron activity and socio-emotional behaviors in mice, revealing differential impacts on anxiety, hyperactivity, and learning.

Sleep need driven oscillation of glutamatergic synaptic phenotype

The paper shows sleep loss alters glutamatergic synaptic properties in the neocortex, which are reversed by sleep, and links these changes to sleep-related genes and MEF2c/HDAC4 regulation.

Juggling the Limits of Lucidity: Searching for Cognitive Constraints in Dream Motor Practice

This study investigates whether complex motor skills like juggling can be performed in lucid dreams and identifies psychological factors influencing dream control.

ELECTROPHYSIOLOGICAL CORRELATES OF CONSCIOUS EXPERIENCES DURING SLEEP: LUCID DREAMS, SLEEP PARALYSIS, OUT-OF-BODY EXPERIENCES, AND FALSE AWAKENINGS

The paper examines electrophysiological correlates of conscious sleep states like lucid dreams and sleep paralysis, distinguishing them from standard sleep stages using polysomnography and statistical analysis.

Random auditory stimulation disturbs traveling slow waves and declarative memory

This study investigates how random auditory stimulation during sleep affects slow-wave dynamics and declarative memory, finding reduced slow-wave sleep and impaired memory recall.

Drug-induced versus non-pharmacological wakefulness: similar or different states? A whole brain analysis in TRAP2 transgenic mice

The paper compares brain activation patterns induced by wakefulness drugs and non-pharmacological methods in mice, revealing distinct neural populations involved.

Increased slow wave activity in response to sleep deprivation is highest immediately after micro-arousals

The paper investigates how micro-arousals affect neural activity in the motor cortex of sleep-deprived mice, finding increased slow wave activity immediately after micro-arousals.

Arousal State Control of Physiological Human Brain Pulsations

This study uses fast fMRI to compare brain pulsation patterns in healthy awake individuals, healthy sleepers, and narcolepsy type 1 patients, revealing how hypocretin deficiency affects cerebrospinal fluid dynamics.

Theta oscillations tag memories for sleep-dependent consolidation

The paper identifies theta oscillations as a mechanism for tagging memories during learning, which predicts sleep-dependent consolidation through coupling with slow oscillations and sleep spindles.

Chronic chemogenetic slow-wave sleep enhancement in mice

This study demonstrates that chronic chemogenetic activation of PZGABA neurons in mice increases slow-wave sleep (SWS) duration and slow wave activity for six months, with effects persisting after drug discontinuation.

Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep

This study uses EEG-PET-MRI to show how hemodynamic and metabolic dynamics change during wakefulness and NREM sleep, revealing coupled temporal patterns and distinct network activity.

Activation of locus coeruleus noradrenergic neuronsrapidly drives homeostatic sleep pressure

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.

Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions

Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice

The paper identifies three distinct subpopulations of L1 NDNF interneurons in mice that show opposite activation patterns during NREM sleep oscillations, with implications for memory consolidation.

Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

This paper introduces fractal cycles as a new definition of sleep cycles based on fractal neural activity, showing correlations with classical cycles and differences across age groups and depression states.

Long-term multichannel recordings in Drosophila flies reveal distinct responses to deviant visual stimuli during sleep compared to wake

The paper shows that Drosophila brains respond to visual stimuli during sleep, with response amplitudes depending on stimulus probability and location.

Shaping the structural dynamics of motor learning through cueing during sleep

This study investigates how Targeted Memory Reactivation during sleep affects microstructural brain changes after motor learning, showing distinct neural reorganization patterns in motor-related areas.

Limited involvement of Ca2+/calmodulin-dependent kinase II alpha and beta in mammalian sleep

The paper reexamines the sleep phenotype in Camk2a and Camk2b knockout mice, finding sleep reduction in Camk2a but not Camk2b mutants, and both participating in homeostatic sleep rebound.

Solriamfetol enhances alertness and cognitive performance in mice

This study shows that low-dose Solriamfetol improves memory and attention in wild-type mice by enhancing EEG fast-gamma activity and reducing delta activity.