Sleep and Wakefulness Research

Functional connectivity drifts during sleep as a marker of fluctuations in the level of consciousness

This study examines functional connectivity in rats during the wake-sleep cycle to determine if consciousness fluctuates within brain states.

Centella asiatica improves sleep quality and quantity in aged mice

This study investigates the effects of Centella asiatica extract on sleep patterns in aged mice, finding sex-dependent improvements in sleep quantity and quality.

Memory control deficits in the sleep-deprived human brain

This study shows that sleep deprivation disrupts prefrontal inhibition of memory retrieval, linking sleep loss to intrusive memories through impaired neural circuits.

Aperiodic neural activity distinguishes between phasic and tonic REM sleep

This study differentiates phasic and tonic REM sleep states using aperiodic neural activity slopes, showing phasic states have steeper low-band and flatter high-band slopes, and EM amplitudes correlate with these slopes.

Longer Interstimulus Intervals Enhance Efficacy of Automated Phase-Targeted Auditory Stimulation on Procedural Memory Consolidation

This study shows that longer interstimulus intervals in automated up-phase-targeted auditory stimulation improve overnight procedural memory consolidation by enhancing K-complexes and spindle coupling.

Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki's Castle

This paper uses phylogenomics to identify sleep-related genes in Lokiarchaeota, suggesting a conserved role for sleep in cellular maintenance and organismal fitness.

LPS-induced sepsis disrupts brain activity in a region- and vigilance-state specific manner

This study shows that LPS-induced sepsis disrupts brain activity patterns in specific brain regions and vigilance states, with early changes in sleep-wake dynamics preceding spectral alterations.

Circuit-Level Dynamics of Slow Wave Activity and Propagation During the Awakening Process

This study examines SWA dynamics during mouse awakening from anesthesia, showing state-dependent changes in spectral power and propagation patterns across brain regions.

Time-Resolved Neural Oscillations Across Sleep Stages: Associations with Sleep Quality and Aging

This study examines EEG spectral power dynamics across sleep stages and their associations with sleep quality and aging, revealing novel relationships between frequency bands and sleep metrics.

Multi-night EEG reveals positive association between sleep efficiency and hippocampal subfield volumes in healthy aging

The paper examines the association between objective sleep efficiency and hippocampal subfield volumes in older adults, finding a positive link with entorhinal cortex volume and better memory performance.

A Comparative Study of Muscular, Vestibular, and Haptic Stimulation on Dream Incorporation

This study investigates how different somatosensory stimulations affect dream incorporation, finding no significant difference between stimulation and sham conditions.

Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress

This study investigates how chronic short sleep affects metabolism and survival under oxidative stress in mutants, finding common metabolic defects and suggesting lipid metabolism issues may underlie oxidative stress sensitivity.

REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals

The paper examines how REM sleep disruption and vagal activity during REM predict extinction memory in trauma-exposed individuals, finding that both factors are linked to poorer memory outcomes.

Slow oscillation-spindle coupling predicts sequence-based language learning

This study finds that slow oscillation-spindle coupling during sleep predicts better sequence-based language learning and is linked to memory consolidation and theta activity.

Heat Shock Factor 1 Governs Sleep-Wake Cycles Across Species

This study shows HSF1 regulates sleep-wake cycles in mice and Drosophila by affecting synaptic organization and sleep-related gene expression.

Visual training induced occipital fast sleep spindle clustering in humans revealed by full-night HD-EEG recordings

This study shows that visual training increases fast sleep spindle density and clustering in young adults, with no age-related differences.

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration

The paper demonstrates that mCLAS adaptively rescues disease-specific sleep and wake phenotypes in AD and PD mouse models.

NREM sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives

The paper examines sleep spindle activity and memory consolidation in early psychosis patients and their relatives, finding spindle deficits and memory issues in patients but not relatives.

Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles

The paper identifies PKA and phosphatases as regulators of sleep-wake cycles through genetic and functional studies in mice.

Cross-Kingdom Genomic Conservation of Human Sleep-Related Gene Orthologs: Phylogenomic Evidence from Chlamydomonas reinhardtii

This study identifies conserved sleep-related gene orthologs in Chlamydomonas reinhardtii, suggesting evolutionary continuity of sleep functions across species.

Sleep Disruption Improves Performance in Simple Olfactory and Visual Decision-Making Tasks

This study shows that sleep disruption improves performance in visual and olfactory decision-making tasks in larval zebrafish by increasing reaction times and correct decisions.

The role of REM sleep in neural differentiation of memories in the hippocampus

This study investigates whether REM sleep facilitates hippocampal memory differentiation after prediction errors, finding greater differentiation in REM sleep conditions in specific hippocampal regions.

Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism

This study identifies heightened LC-NE neuron activity and altered connectivity as causes of sleep fragmentation and memory deficits in a 16p11.2 deletion ASD mouse model.

Developing forebrain synapses are uniquely vulnerable to sleep loss

This study examines the effects of sleep deprivation on synaptic vulnerability across developmental stages in mice, finding heightened sensitivity in juveniles and links to ASD risk.

Mapping the physiological changes in sleep regulation across infancy and young childhood

The paper uses a mathematical model to analyze sleep patterns in infants and young children, finding developmental changes in sleep homeostasis and circadian rhythms.

Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus

The paper analyzes OXR1 and OXR2 mRNA expression in the dorsal hippocampus and related brain regions using RNAscope in situ hybridization, revealing distinct expression patterns and cell-type specificity.

Local sleep in songbirds: Different simultaneous sleep states across the avian pallium

The paper examines local sleep states in zebra finches, finding that sleep stages vary across different regions of the avian pallium, challenging the idea of global sleep states.

A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep

This study identifies a hypothalamic circuit involving CRHPVN neurons that mediates stress-induced impairments in memory and sleep.

The human claustrum tracks slow waves during sleep

The paper records claustrum neurons during human sleep and finds they increase activity and track slow waves during NREM sleep.

Impact of Optogenetic Activation of the Thalamic Reticular Nucleus on Sleep Architecture in Mice

This study investigates the effect of optogenetic activation of GABAergic TRN neurons on sleep architecture in mice, finding no significant changes in sleep state durations or delta wave power.