Sleep and Wakefulness Research

Cholinergic regulation of sleep in the upside-down jellyfish Cassiopea

This study identifies a cholinergic mechanism regulating sleep in the jellyfish Cassiopea, showing that Chrnal-E promotes wakefulness and its expression changes with sleep deprivation.

Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons

This study investigates the role of preoptic glutamatergic neurons in REM sleep regulation, finding they suppress REMs and disrupt sleep homeostasis when activated.

Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state

The paper examines cortical acetylcholine dynamics during behavioral state transitions, finding that axon activity and behavior predict ACh levels.

Spatiotemporal patterns of theta-band activity during rapid-eye movement sleep: a magnetoencephalography analysis

This study uses M/EEG to characterize theta-band activity during REM sleep, comparing it to working memory task-induced theta and identifying distinct spatial and frequency patterns.

Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila

This study shows that vibration-induced sleep in Drosophila improves learning, memory, and clearance of harmful proteins associated with Alzheimer's disease.

Interpreting Sleep Activity Through Neural Contrastive Learning

The paper develops a neural network model, Sleep Interpreter (SI), to decode memory replay from sleep EEG and shows it can accurately detect reactivation during sleep that correlates with memory performance.

Disarming emotional memories using Targeted Memory Reactivation during Rapid Eye Movement sleep

This study shows that targeted memory reactivation during REM sleep reduces emotional responses by decreasing brain activity and physiological arousal to emotional stimuli.

Cardiac responses to auditory irregularities reveal hierarchical information processing during sleep

The paper examines cardiac responses to auditory irregularities during sleep, showing slowed cardiac activity to global deviants in REM sleep and cardiac acceleration in light NREM sleep, indicating hierarchical information processing variations.

Neither fifty percent slow-wave sleep suppression nor fifty percent rapid eye movement sleep suppression does impair memory consolidation

This study shows that reducing SWS or REM by 50% does not impair memory consolidation and may even improve psychomotor vigilance and procedural skills.

FEATURE-SPECIFIC ANTICIPATORY PROCESSING FADES DURING HUMAN SLEEP

This paper investigates predictive processing during sleep by analyzing neural responses to predictable and random tones using EEG and MEG, finding that predictive patterns fade as sleep progresses.

TAAR2-9 Knockout Mice Exhibit Reduced Wakefulness and Disrupted REM Sleep

This study examines the effects of TAAR2-9 knockout on sleep/wake patterns in mice, finding altered REM sleep and wakefulness but no difference in homeostatic response to sleep loss.

Wakefulness induced by TAAR1 partial agonism is mediated through dopaminergic neurotransmission

This study shows that TAAR1 partial agonism increases wakefulness and reduces NREM sleep in mice, with D1R and D2R antagonists modulating these effects differently.

Novelty and anxiety differentially shape hippocampal assembly reactivation and sequence replay during REM sleep

This study investigates neural reactivation during REM sleep in mice, finding that novel and anxiety-related experiences shape distinct patterns of hippocampal assembly reactivation and sequence replay.

Predictive Modeling of Sleep Slow Oscillation Emergence on the electrode manifold: Toward Personalized Closed-Loop Brain Stimulation

This paper develops a predictive model for sleep slow oscillation (SO) occurrences during NREM sleep, enabling more precise targeting for brain stimulation by analyzing SO timing and decay patterns across sleep cycles.

Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

This study uses closed-loop auditory stimulation in mice to enhance slow-wave activity, improving sleep quality in Alzheimer's and Parkinson's disease models.

A sleep disturbance method by novel objects in the home cage to minimize stress

This paper introduces a seven-day sleep disturbance protocol using novel objects to minimize stress in mice and demonstrates its effectiveness and reduced stress compared to existing methods.

Closed-loop auditory stimulation targeting alpha and theta oscillations during REM sleep induces phase-dependent power and frequency changes

This study shows that closed-loop auditory stimulation can modulate alpha and theta oscillations during REM sleep in a phase-dependent manner, altering power and frequency.

Acoustically evoked K-complexes together with sleep spindles boost verbal declarative memory consolidation in healthy adults

Boundary conditions for synaptic homeodynamics during the sleep-wake cycle

The paper uses computational models to explore synaptic dynamics during the sleep-wake cycle, finding that wake-like firing patterns decrease synaptic weights while sleep-like patterns increase them, offering a unified framework for synaptic homeodynamics.

The brain simulates actions and their consequences during REM sleep

This study shows that during REM sleep, the mouse brain issues motor commands that shift internal direction representations, simulating actions and their consequences without physical execution.

The role of TRPV4 in acute sleep deprivation-induced fear memory impairment

This study shows that TRPV4 knockdown improves fear memory deficits caused by acute sleep deprivation by reducing Ca2+ overload and restoring synaptic plasticity.

Arousal threshold reveals novel neural markers of sleep depth independently from the conventional sleep stages

This paper identifies novel neural markers of sleep depth using auditory arousal threshold instead of conventional sleep stages, revealing unique brain network correlations.

Scheduled feeding improves sleep in a mouse model of Huntington's disease.

This study shows that scheduled feeding improves sleep patterns in male but not female Huntington's disease mouse models.

Sleep maintains excitatory synapse diversity in the cortex and hippocampus

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

Sleep consolidation potentiates skill maintenance

This study investigates the role of sleep in motor skill maintenance through experiments showing sleep enhances memory retention when training occurs before bedtime.

Aversive memories can be weakened during human sleepvia the reactivation of positive interfering memories

This study weakens aversive memories during sleep by reactivating positive memories, reducing recall and increasing positive memory intrusions.

A distinct down state assembly in retrosplenial cortex during slow-wave sleep

The paper identifies a distinct neuronal subpopulation in the retrosplenial cortex that fires during slow-wave sleep Down states and is involved in memory consolidation.

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

Cortical layer-specific and cell type-specific dendritic expression of Arc (Arg 3.1) in an in vitro model of slow-wave sleep

The paper shows Arc protein is specifically expressed in dendrites of layer 2/3 in association cortex during slow-wave sleep in vitro, linked to intrinsically bursting cells in layer 5.

Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture

This study shows that astrocytic lactate supply via MCT4 and MCT2 is essential for maintaining wakefulness and sleep stability by supporting orexinergic neuron activity.