Sleep and Wakefulness Research

The timing of sleep spindles is modulated by the respiratory cycle in humans

This study examines how the respiratory cycle modulates sleep spindles and slow waves during N2 sleep in humans, finding significant coupling between spindles and respiration phases.

The dynamic gene regulatory landscape of the mouse brain in response to sleep deprivation

This study investigates how sleep deprivation alters gene regulatory networks in three mouse brain regions using multiomic analysis, revealing region-specific epigenomic changes.

Restoration of locus coeruleus noradrenergic transmission during sleep

The paper shows that noradrenaline transmission from the locus coeruleus decreases with wakefulness and recovers during sleep, with mTOR signaling involved in recovery.

Sleep homeostasis in a naturalistic setting

This study shows that increased wakefulness before sleep leads to deeper sleep and improved sleep efficiency in a naturalistic setting.

Neural correlates of nightmares revisited: findings from large-scale fMRI cohorts

This study investigates the neural correlates of nightmares using fMRI data from large cohorts but fails to replicate previous findings on amygdala-prefrontal connectivity and ReHo differences.

Consciousness in Non-REM parasomnia episodes

This study interviews patients with Non-REM parasomnias to characterize the variability in consciousness and environmental disconnection during episodes, finding a spectrum from automatic behaviors to dream-like conscious experiences.

A REM-active basal ganglia circuit that regulates anxiety

This paper identifies a REM-active basal ganglia circuit in mice that regulates REM sleep and anxiety by showing its role in sleep duration and behavioral responses to aversive stimuli.

NREM sleep brain networks modulate cognitive recovery from sleep deprivation

The paper investigates how NREM sleep stages N2 and N3 modulate cognitive recovery after sleep deprivation by analyzing brain network segregation using fMRI and a new hierarchical segregation index.

N2 Sleep Inspires Insight

This study investigates the relationship between sleep stages and insight, finding that N2 sleep increases insight likelihood, while spectral slopes predict insight beyond sleep stages.

Prefrontal coding of learned and inferred knowledge during REM & NREM sleep

The paper shows that NREM and REM sleep play distinct roles in forming inferential knowledge, with NREM organizing learned information and REM computing inferences from it.

First-night effect reduces the beneficial effects of sleep on visual plasticity and modifies the underlying neurochemical processes

The paper shows the first-night effect reduces sleep's benefit on visual plasticity and alters neurochemical processes during sleep.

Inducing lucid dreaming with multisensory stimulation: a preregistered multi-center study

This study tests a combined sensory and cognitive approach to induce lucid dreaming, finding higher rates of signal-verified lucid dreams with sensory cues compared to sham conditions.

Spindle-locked ripples mediate memory reactivation during human NREM sleep.

This study shows that spindle-locked ripples in human NREM sleep are critical for memory reactivation, supporting their role in memory consolidation.

Noradrenergic tuning of arousal is coupled to coordinatedmovements

This study shows that locus coeruleus norepinephrine (LCNE) activity is coupled to movement initiation and arrest during waking and anesthesia, revealing its role in coordinating arousal and motor activity.

Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus

This study identifies GABAergic neurons in the hypothalamic preoptic area that regulate REM sleep homeostasis by responding to REM sleep restriction and mediating rebound.

Targeted memory reactivation during non-rapid eye movement sleep enhances neutral, but not negative, components of memory

This study shows that targeted memory reactivation during NREM sleep improves neutral memory but not negative memory, with sleep spindles mediating the effect for neutral items.

Intra-amygdala circuits of sleep disruption-induced anxiety in female mice

This study investigates how sleep disruption affects anxiety-related circuits in female mice by examining synaptic changes in BLA to CRF-CeL projections.

Impaired sleep-dependent memory consolidation predicted by reduced sleep spindles in Rolandic epilepsy

This study finds that reduced sleep spindles in children with active Rolandic epilepsy predict impaired sleep-dependent memory consolidation.

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in basal forebrain

This paper identifies Npas1+ neurons in the basal forebrain as a major GABAergic subpopulation involved in wakefulness and sleep regulation.

The number of effectors limits the relative sleep gain: Insights from seven finger tapping experiments

The paper investigates how the number of effectors in a finger tapping task affects sleep-dependent motor memory consolidation, finding that sleep benefits motor learning except when using one hand and one finger.

Slow Oscillations Modulate Functional Brain Changes Supporting Working Memory

This study investigates how slow oscillations during sleep modulate working memory-related neural activity changes overnight.

Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons

This study shows that optogenetic stimulation of cortical neurons can awaken mice from sleep, coma, and anesthesia, indicating cortical sufficiency for arousal.

Multiomics analysis of narcolepsy T cells: global hypomethylation in solo-WCGW motif linked to T cell proliferation

The paper identifies global hypomethylation in T cells of narcolepsy type 1 patients, linked to solo-WCGW motifs and T cell proliferation.

An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking

This study identifies an EEG signature that tracks MCH neuron activity and predicts cocaine seeking behavior in rats.

The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila

This study shows that Dif, an NFκB transcription factor in Drosophila, regulates daily sleep and recovery sleep after sleep deprivation, with effects mediated through neuronal pathways.

Delineating memory reactivation in sleep with verbal and non-verbal retrieval cues

This study investigates how verbal and non-verbal retrieval cues affect memory reactivation in sleep, finding verbal cues elicit stronger spindle activity than non-verbal cues.

Memory reactivation during sleep does not act holistically on object memory

The paper investigates how sleep reactivation affects memory transformation by improving distinguishing features while worsening shared features of object memories.

Purkinje cell dysfunction causes disrupted sleep in ataxic mice

This study shows that Purkinje cell dysfunction in ataxic mice disrupts sleep architecture, with reduced wakefulness and REM sleep and increased NREM sleep.

Differential effects of the stress peptides PACAP and CRF on sleep architecture in mice

This study investigates how PACAP and CRF, two stress peptides, affect sleep architecture in mice, finding distinct impacts on sleep stages and behavior.

A direct estrogenic involvement in the expression of human hypocretin

The paper investigates how estrogen receptors directly regulate hypocretin expression in the hypothalamus, linking estrogen to sex-specific depression mechanisms.