Sleep and Wakefulness Research

A Novel Role for Phospholamban in the Thalamic Reticular Nucleus

This study identifies a novel role for phospholamban in regulating thalamic reticular nucleus function, linking it to behavioral phenotypes like hyperactivity and sleep disturbances in mice.

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's Disease

The paper studies sleep-wake abnormalities in a new PD mouse model and finds they mirror human PD symptoms, suggesting potential for understanding and treating sleep disruptions in PD.

The wake- and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimers disease

This study examines the differential degeneration of wake- and sleep-modulating neurons in Alzheimer's disease, finding significant loss of orexinergic neurons and relative preservation of MCHergic neurons.

Sex specific regulation of the cortical transcriptome in response to sleep deprivation

The paper identifies sex-specific transcriptomic changes in the cerebral cortex of male and female mice after sleep deprivation, highlighting differential regulation of genes like Bdnf and Fosb.

Sleep spindle density and temporal clustering are associated with sleep-dependent memory consolidation in Parkinson's disease

This study investigates the relationship between sleep spindles and memory consolidation in Parkinson's disease patients, finding that lower spindle density and reduced temporal clustering are associated with worse memory consolidation.

Wake EEG oscillation dynamics reflect both sleep pressure and brain maturation across childhood and adolescence

The paper shows wake EEG oscillation amplitudes and aperiodic offsets correlate with sleep slow waves, reflecting sleep pressure and brain maturation across childhood and adolescence.

Kir6.2-KATP channels alter glycolytic flux to modulate cortical activity, arousal, and sleep-wake homeostasis

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

A half-centre oscillator encodes sleep pressure

The paper identifies a half-centre oscillator in Drosophila that generates slow-wave activity linked to sleep regulation and pressure.

Individualized temporal patterns dominate cortical upstate and sleep depth in driving human sleep spindle timing

The paper identifies individualized temporal patterns as the main determinant of sleep spindle timing in humans, using data from 1008 participants.

Shorter self-reported sleep duration in men is associated with worse virtual spatial navigation performance

The paper finds that longer self-reported sleep duration in men is linked to better virtual spatial navigation performance, while no such association is found in women.

All-night spectral and microstate EEG analysis in patients with Recurrent Isolated Sleep Paralysis (RISP)

This study analyzes EEG spectral and microstate patterns in RISP patients during non-episodic sleep, finding increased theta power and altered microstate transitions compared to controls.

Characterizing the power spectrum dynamics of the NREM to REM sleep transition

The paper analyzes the spectral dynamics during the NREM to REM sleep transition in rats, identifying specific power changes in different brain regions that precede REM sleep onset.

Acute sleep deprivation reduces fear memories in male and female mice

This study shows that sleep deprivation after fear conditioning reduces fear memories in mice, possibly through BDNF-mediated neuroadaptations in the amygdala.

A visual paired associate learning (vPAL) paradigm to study memory consolidation during sleep

The paper introduces a visual paired association learning paradigm to study memory consolidation during sleep and finds that naps improve recognition memory stability but not cued recall.

Contrasting contribution of embryo- and postnatally-derived brain-resident macrophages in sustaining sleep-wake circuitry

This study shows that embryonic and postnatally-derived brain macrophages have distinct roles in regulating sleep-wake cycles and synaptic balance, with postnatal repopulation failing to restore normal sleep patterns.

Spontaneous oxycodone withdrawal disrupts sleep, circadian, and electrophysiological dynamics in rats

This study examines how spontaneous oxycodone withdrawal affects sleep, circadian rhythms, and EEG dynamics in rats over time.

Odor cueing of declarative memories during sleep enhances coordinated spindles and slow oscillations

This study shows that odor cueing during sleep increases sleep spindles and slow oscillations, which may enhance declarative memory consolidation.

Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

Neurophysiological Correlates of Phase-Specific Enhancement of Motor Memory Consolidation via Slow-Wave Closed-Loop Targeted Memory Reactivation

This study investigates how phase-specific targeted memory reactivation during sleep affects motor memory consolidation, finding that up-state cues improve performance and alter neural activity.

Genetic and chemical disruption of Amyloid Precursor Protein processing impairs zebrafish sleep maintenance

This study shows that APP processing into Aβ40 and Aβ42 is conserved in zebrafish and that disrupting this processing affects sleep maintenance.

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

This study shows that miR-709 regulates NREM sleep EEG slow waves by linking glutamatergic signaling to neuronal activity through endosomal trafficking.

Clustering and temporal organization of sleep spindles underlie motor memory consolidation

The paper shows that sleep spindles cluster in NREM2 sleep, supporting motor memory consolidation through synchronized oscillatory activity.

Sleep selectively and durably enhances real-world sequence memory

The paper shows sleep selectively enhances sequence memory for real-world experiences over time, with effects growing up to one year post-encoding.

Whole brain mapping of orexin receptor mRNA expression visualized by branched in situ hybridization chain reaction

This study uses a new branched in situ hybridization chain reaction technique to map orexin receptor mRNA expression in mouse brains, revealing distinct distributions and cell types expressing OX1R and OX2R.

Tracing diurnal differences in brain anatomy with voxel-based morphometry - associations with sleep characteristics

The paper investigates diurnal changes in brain anatomy using voxel-based morphometry and links them to sleep characteristics in a large dataset.

Sleep restores an optimal computational regime in cortical networks

This study shows that sleep restores criticality in cortical networks, a computational regime that optimizes information processing, more accurately than traditional measures like SWA.

Chemogenetic activation of astrocytes modulates sleep/wakefulness states in a brain region-dependent manner

This study shows that chemogenetic activation of astrocytes in specific brain regions affects sleep/wakefulness states and cortical oscillations differently.

The Neural Correlates of Arousal: The Ventral Posterolateral Nucleus-Global Transient Co-Activation

The paper identifies that co-activation of the ventral posterolateral nucleus and global brain activity correlates with physiological arousal but not perceptual awareness.

EEG and computational aspects of how aging affects sleep slow waves

The paper quantifies age-related changes in sleep slow waves using EEG data and a computational model, finding slowed dynamics, increased variability, and reduced amplitude with age.

Sustained polyphasic sleep restriction abolishes human growth hormone release

This study examines the effects of sustained polyphasic sleep restriction on human growth hormone release and other physiological and cognitive measures.