Sleep and Wakefulness Research

Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons

The paper identifies QRFP/Pth4 neurons in zebrafish hypothalamus as a novel sleep-promoting population that acts through hindbrain monoaminergic neurons.

Brainstem circuit for sickness-induced sleep

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

Use of RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness

The paper compares gene expression profiles from sleep and anaesthesia-induced unconsciousness to identify gene sets associated with specific neuronal populations and pathways.

An anterior-posterior gradient in hippocampal subfield volumes linking sleep health to cognition in young adults

This study links sleep health to hippocampal subfield volumes and cognitive performance in young adults using multiset canonical correlation analysis.

Lemborexant Reduces Infarct Volume and Improves Long-Term Functional Recovery in a Murine Model of Ischemic Stroke

This paper shows that lemborexant reduces infarct volume and improves motor recovery in a mouse model of ischemic stroke by stabilizing sleep.

Respiratory coordination of excitability states across the human wake-sleep cycle

This study examines how respiratory rhythms influence aperiodic brain activity during the wake-sleep cycle in humans, finding phase shifts and reduced variability in respiration-brain coupling during sleep transitions.

Sleep controls peroxisomal abundance to reduce wake-induced brain oxidation

This study shows that sleep regulates peroxisomal abundance to reduce brain oxidation caused by wakefulness, with Pex16 playing a key role in sleep regulation and lipid metabolism.

Study of changes in brain dynamics during sleep cycles in dogs under effect of trazodone

This study examines how trazodone affects brain dynamics in dogs during sleep cycles using EEG analysis, finding changes in sleep structure, power distribution, and connectivity.

Sleep-like slow waves in wakefulness index post-stroke behavioural alterations

This study shows that sleep-like slow waves in wakefulness correlate with perceptual decision-making deficits in stroke patients, indicating network destabilization beyond the lesion site.

The Role of Sleep Duration and Age in Neural Reactivation and Episodic Memory Performance Across the Adult Lifespan

This study examines how sleep duration and age affect neural reactivation and episodic memory performance across adulthood, finding significant correlations between sleep duration and encoding-retrieval similarity in specific brain regions.

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

This study investigates BACE1's role in sleep-wake cycles through enzymatic and non-enzymatic actions using mouse models, finding altered sleep patterns and EEG characteristics in mutants.

Phase precession of spindle-slow oscillation coupling across the human brain

The paper investigates phase precession of spindle-slow oscillation coupling across the human brain, finding it declines with age and is robust across individuals.

Nighttime sleep promotes mechanosensory habituation in Drosophila

This study shows that nighttime sleep in Drosophila is necessary for mechanosensory habituation, likely by promoting synaptic downscaling.

Dynamic stomach-brain electrical coupling in human sleep

This study shows that gastric electrical rhythms during sleep are synchronized with cortical oscillations and predict memory recall and sleep quality.

Wake consolidates event memory, sleep binds it with context

The paper shows that sleep enhances memory binding with context while wakefulness stabilizes memory representations independently of context.

Sleep Deprivation in Mice: Looking Beyond the Slow Wave Rebound

This study compares spectral metrics to classical indices in mice sleep deprivation, finding that fractal parameters better capture sleep state changes than slow wave activity.

Unconscious switching of dorsal and medial pathways for plasticity and stability during NREM and REM sleep

The paper shows that during non-REM sleep, plasticity increases in the DLPFC, while during REM sleep, stability increases in the mPFC, both related to E/I balance changes and learning outcomes.

Early Sleep-Dependent Sensory Gating in the Olfactory System

The paper investigates sleep-dependent sensory gating in the olfactory system, showing reduced olfactory bulb activity during sleep and its correlation with neocortical slow-wave activity.

Energy Deficit is a Key Driver of Sleep Homeostasis

The paper shows that energy deficit drives sleep homeostasis in Drosophila by linking sleep loss to increased metabolic expenditure and food intake, followed by rebound sleep.

Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow

This study shows that sleep deprivation leads to attentional failures linked to increased cerebrospinal fluid flow and systemic physiological changes.

Local modulation of sleep slow waves depends on timing between auditory stimuli

The paper re-analyzes hd-EEG data to show that inter-stimulus interval (ISI) determines the type of slow-wave activity (SWA) modulation from phase-targeted auditory stimulation (PTAS), rather than the targeted phase alone.

Circadian and Sleep-Wake Modulation of Functional Connectivity Across Brain Oscillations and States Linked to Cognition in Humans

This study examines how sleep and circadian rhythms affect brain functional connectivity and cognitive performance in humans using a forced-desynchrony protocol.

Presynaptic Release Probability Determines the Need for Sleep

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons

This study identifies prefrontal cortical neurons that regulate both NREM sleep and anesthesia by modulating their activity and connectivity.

Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation? A Bayesian meta-analysis

This paper conducts a Bayesian meta-analysis of 23 studies to assess the role of slow oscillation-spindle coupling in memory consolidation, finding strong evidence for its predictive value.

Human deep sleep facilitates faster cerebrospinal fluid dynamics linked to brain oscillations for sleep homeostasis and memory

The paper shows that deep sleep in humans is linked to faster cerebrospinal fluid dynamics driven by brain oscillations, distinct from arousal mechanisms and light sleep.

Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress

This study examines the relationship between sleep patterns and anhedonia in male mice exposed to early-life stress, finding significant correlations between sleep architecture and anhedonic phenotypes.

Slow-wave sleep and REM sleep differentially contribute to memory representational transformation

This study examines how REM and SWS sleep stages influence memory transformation by analyzing EEG data and representational similarity at item and category levels.

A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

This study performs a meta-analysis of rodent sleep deprivation transcriptome data to identify consistently differentially expressed genes across multiple studies.

Molecular Logic of Cell Diversity and Circuit Connectivity in the REM Sleep Hub

The paper maps the cellular taxonomy and circuit connectivity of the murine sublaterodorsal tegmental nucleus (SLD) using single-nucleus RNA sequencing, revealing a previously unknown pathway involved in REM sleep regulation.