melanin and skin pigmentation

BRN2 preserves the melanocyte lineage following ionizing radiation

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

THE MULTIFUNCTIONAL PROTEIN E4F1 REGULATES MELANOCYTIC FUNCTIONS IN MICE THROUGH PROTEIN TRANSLATION AND MITF EXPRESSION

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

Ciliary regulation of melanogenesis unveils moonlighting roles for Joubert Syndrome proteins

The paper identifies ciliary proteins that regulate melanogenesis in melanocytes and reveals moonlighting roles for Joubert Syndrome proteins in endolysosomal organization.

Extracellular Granzyme B Promotes Melanocytorrhagy, Melanocyte Senescence and Aberrant Epidermal Differentiation in Vitiligo and Is Therapeutically Targetable

This study shows extracellular Granzyme B contributes to vitiligo by causing melanocyte detachment, senescence, and abnormal epidermal differentiation, and identifies it as a therapeutic target.

SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

Colloidally dispersed nanoparticles: a convergent evolutionary approach for the secretion of apparently soluble melanin

The paper isolates and characterizes a new class of soluble melanin from fungi, showing it forms nanoparticles and arises through convergent evolution.

Transcriptomic differences underlying fin sexual dichromatism and male color polymorphism in bluefin killifish (Lucania goodei)

This study identifies transcriptomic differences underlying color variation in bluefin killifish, revealing genes involved in pigment pathways and light-sensitive phenotypic plasticity.

Skin-Related Effects of Corynebacterium amycolatum SB-1 Ferment Filtrate and Functional Characterization of Ellagic Acid

This study identifies ellagic acid from Corynebacterium amycolatum SB-1 as a bioactive compound with anti-melanogenic and collagen-promoting effects on skin cells.

optix regulates abdominal melanin pigmentation in the tobacco hawkmoth Manduca sexta

This study disrupts optix in Manduca sexta and finds it regulates abdominal pigmentation, replacing orange with black eumelanin, suggesting optix modulates an alternative pigment pathway.

Migration and establishment of progenitor pool of melanocytes is governed by SEMA3E-PLXND1 signaling

The paper identifies SEMA3E-PLXND1 signaling as critical for melanocyte migration and establishment, revealing its role in pigment patterning through F-actin modulation and transcriptional responses.

Epigenetic Coalitions Couple Tissue Growth to Generate Periodic Colour Patterns in Birds

The paper shows how epigenetic coalitions in birds couple tissue growth to generate periodic color patterns through ASIP regulation and feedback loops.

Staurosporine drives non-canonical melanocyte maturation by coupling β-catenin signaling to actin-dependent dendrite remodeling

This paper shows that staurosporine induces non-canonical melanocyte maturation by enhancing melanogenesis and dendritic remodeling, promoting pigmentation in vitro and in vivo.

Modulation of Avian Iridescence via Melanogenesis

This study identifies melanogenesis gene mutations that alter feather photonic nanostructures, causing iridescent color changes in peafowl and wild birds.

Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents

The paper develops a pigmented human epidermal equivalent model and shows it has enhanced differentiation potential compared to conventional models.

Computational design of blue melanin with peptide motif scaffolding

This paper designs blue melanin using peptide motifs and computational methods, achieving stable blue color with specific absorption wavelengths and thermal/photostability.

SLC16A6 is a tyrosine transporter for the melanosome

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

A Recessive oca2 Mutation Underlies Albinism in Xiphophorus fish

The paper identifies a recessive oca2 mutation causing albinism in Xiphophorus hellerii fish and explores its role in pigment biology and melanoma.

Museum genomics links MC1R alleles to adaptive winter coat color polymorphism in the long-tailed weasel

The paper uses museum genomics to link MC1R alleles to winter coat color polymorphism in long-tailed weasels, identifying deletions associated with different color morphs.

The optical origin of the human skin color 'banana' in CIELAB space

The paper develops a physics-based framework to link skin chromophore content to colorimeter-derived skin color coordinates, revealing how melanin and blood contribute to the banana-shaped locus in CIELAB space.

Circadian clock regulates epidermal endocrine system in homeostatic skin pigmentation

This study shows that circadian clock genes BMAL1 and CLOCK regulate melanin synthesis in melanocytes by modulating vitamin D signaling.

Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinism

This study shows that reducing sAC activity restores pigmentation in OCA models and increases melanin synthesis, suggesting targeting melanosome pH as a therapeutic strategy for OCA and skin cancer risk.

Hyperdivergent haplotypes control melanic camouflage in a polymorphic moth

This study identifies the ivory:mir-193 locus as a major determinant of melanic color variation in Anticarsia gemmatalis moths, showing that divergent haplotypes and regulatory elements control dark morph pigmentation.

Photoprotective demands predict external eye pigmentation in terrestrial mammals

This study quantifies peri-iridal brightness in terrestrial non-primate mammals and finds that photoprotective demands, eye size, and ecology significantly influence ocular pigmentation.

Optical Limits in Skin Reflectance Measurement: Quantifying Melanin-Dependent Constraints on Erythema Detection

This paper quantifies how melanin limits erythema detection in visible-range skin reflectance measurements by analyzing over 15,000 spectra from the International Skin Spectra Archive.

Somatic mutations distinguish melanocyte subpopulations in human skin

The paper identifies distinct melanocyte subpopulations in human skin based on mutation burden, showing LowMut cells are stem-like and spatially distinct from HighMut cells.

A multiscale physicochemical characterization of melanin-based feather coloration in the rapid Capuchino Seedeater radiation

The paper examines how melanosome morphology and distribution in Capuchino Seedeaters relate to plumage coloration, finding patch-specific differences in melanosome size, shape, and melanin content.

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo

This study identifies melanocyte dedifferentiation as a reversible mechanism in vitiligo and shows that targeting specific pathways can restore pigmentation.

Are you represented? Subjective vs objective skin color determination for healthcare and research purposes.

The paper compares subjective skin color categorization methods with objective spectrophotometer measurements and proposes a new standardized system for better representation and application in healthcare and research.

Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage

The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.

Cell type diversification and phenotype convergence underlying white fin-ornamentation of cyprinid fishes

The paper investigates the developmental and evolutionary origins of white pigment cells in cyprinid fishes, revealing convergent mechanisms across species.