dental development and anomalies

Evolutionarily conserved waves of tooth replacement in the gecko are dependent on local signaling

This study investigates tooth replacement patterns in geckos after tooth removal, finding evidence of local signaling and proposing a new Phase Inhibition Model.

An in vitro and computational validation of a novel loss-of-functional mutation in PAX9 associated with non-syndromic tooth agenesis

The paper identifies a novel PAX9 mutation causing non-syndromic tooth agenesis through in vitro and computational analysis.

Notch signaling pathway in tooth shape variations

This study shows that Notch signaling, specifically through Jagged1, influences tooth-crown shape variations in mice, mirroring evolutionary changes observed in Muridae.

Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics

This study shows that Med1 deletion in dental epithelia causes a shift from enamel to hair lineage through changes in enhancer dynamics and transcriptional programs.

Human iPSC Derived Enamel Organoid Guided by Single-Cell Atlas of Human Tooth Development

The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.

USAG1 protein: An important drug target in teeth regeneration

This study identifies USAG-1 as a drug target for teeth regeneration and proposes a natural lead molecule to induce regeneration while addressing side effects.

Foxi3 Suppresses Signaling Center Fate and is Necessary for the Early Development of Mouse Teeth

This study investigates the role of Foxi3 in early tooth development, showing its necessity in suppressing signaling center fate and regulating epithelial proliferation and shape.

Understanding the development of oral epithelial organs through single cell transcriptomic analysis

This study maps the transcriptional landscape of developing mouse mandibular epithelium to identify key transcription factors and gene regulatory networks involved in oral epithelial patterning and organ specification.

An ancient dental signalling centre supports homology of an enamel knot in sharks

The paper shows that an enamel knot-like signalling centre is conserved in sharks, supporting its homology across vertebrates despite differences in signalling.

Integration of multimodal data in the developing tooth reveals candidate dental disease genes

The paper identifies candidate dental disease genes by integrating chromatin state, bulk gene coexpression, and single-cell RNA sequencing data from developing mouse teeth.

A minimal tooth enhancer regulates dlx2b expression during zebrafish tooth formation: insights into cis-regulatory logic in organogenesis

The paper identifies a minimal tooth enhancer that regulates dlx2b expression in zebrafish tooth development and shows how its disruption affects gene expression patterns.

Unraveling the roles of Mast4 in amelogenesis via regulating DLX3 and stem cell maintenance of mouse incisors

This study identifies MAST4's role in regulating DLX3 and stem cell maintenance in mouse incisor development, leading to Amelogenesis Imperfecta.

FGF8-mediated signaling regulates tooth developmental pace during odontogenesis

This study shows that FGF8 signaling in the dental mesenchyme slows tooth development by promoting cell proliferation and blocking apoptosis.

An evolutionarily conserved odontode gene regulatory network underlies head armor formation in suckermouth armored catfish

This study identifies an evolutionarily conserved odontode gene regulatory network in suckermouth armored catfish that underlies dermal denticles development.

Identification of enamel knot gene signature within the developing mouse molar

The paper identifies a gene signature specific to the enamel knot in developing mouse molars using scRNA-seq data and validates novel marker genes.

Distinct tooth regeneration systems deploy a conserved battery of genes

The paper compares tooth regeneration systems in zebrafish and stickleback to show they use a conserved set of genes during regeneration.

Spectrum of pathogenic variants and multiple founder effects in amelogenesis imperfecta associated with MMP20

The paper identifies new pathogenic variants in the MMP20 gene associated with autosomal recessive amelogenesis imperfecta and explores their genetic origins across different populations.

Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development

This study shows that Tfap2a and Tfap2b have tissue-specific roles in tooth development, with epithelial expression critical for incisor morphology and mesenchymal expression having little effect.

Hedgehog signalling regulates patterning of the murine and human dentitions through Gas1 co-receptor function

This study shows that Gas1 regulates tooth number and morphology in mice and humans by modulating Hedgehog and Wnt signaling during development.

System-level analyses of keystone genes required for mammalian tooth development

The paper identifies developmental keystone genes in mouse and rat tooth development by analyzing phenotypic severity and gene expression patterns, revealing conserved system-level dynamics.

Tgfbr2 in dental pulp cells guides sensory innervation in developing teeth

This study shows that Tgfbr2 in dental pulp mesenchyme regulates paracrine signals that guide sensory innervation of developing teeth.

Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

The paper models Edar expression dynamics to reveal hidden patterning processes in tooth signaling centers, showing a two-step activation and erasure mechanism.

A de novo EDA-variant in a litter of shorthaired standard Dachshunds with X-linked hypohidrotic ectodermal dysplasia

The paper identifies a de novo EDA mutation causing X-linked hypohidrotic ectodermal dysplasia in shorthaired standard Dachshunds through whole-genome sequencing and family analysis.

Unbiased association and expression studies identify novel genes for tooth development

The paper identifies novel genes for tooth development by associating CRC risk variants with tooth agenesis and showing gene expression in developing teeth.

Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth

This study shows that zebrafish lacking sp7 can replace teeth without attachment bone, but with poor differentiation and abnormal tooth orientation.

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells (MSCs)

This study shows BMP signaling is required for MSC lineage commitment and identifies downstream transcription factors that determine cellular identities in dental mesenchyme.