Axon Guidance and Neuronal Signaling

Regulation of subcellular dendritic synapse specificity by axon guidance cues

The paper investigates how axon guidance cues determine subcellular synapse specificity in Drosophila neurons, showing that these cues, not distinct dendritic domains, dictate synaptic connections.

In vivo topology converts competition for cell-matrix adhesion into directional migration

The paper shows how in vivo topology transforms competition for cell-matrix adhesion into directional migration through Sdf1 and Sema3A interactions.

The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila

This study shows that intrinsic temporal identity, determined by the Hunchback transcription factor, dictates axon and dendrite targeting in Drosophila motor neurons, overriding birth order.

Dynamic alterations of retinal EphA5 expression in retinocollicular map plasticity

The paper investigates how retinal EphA5 expression changes after injury and how these changes relate to retinocollicular map plasticity.

A multicellular rosette-mediated collective dendrite extension

The paper shows that C. elegans amphid neurons form a multicellular rosette to collectively extend dendrites, using adhesion molecules and mechanical cues from surrounding tissues.

Dystroglycan is a scaffold for extracellular axon guidance decisions

This study identifies Dystroglycan as an extracellular scaffold that coordinates axon guidance by interacting with environmental cues and the receptor Celsr3/Adgrc3.

Nell2 regulates the contralateral-versus-ipsilateral visual projection as a layer-specific positional cue

The paper shows Nell2 is an ipsilateral layer-specific axon guidance cue in the visual thalamus that inhibits contralateral retinal axons, establishing eye-specific retinogeniculate projections.

Spatial and temporal profiling of receptor membrane insertion controls commissural axon responses to midline repellents

The paper investigates how commissural axons develop sensitivity to midline repellents through receptor dynamics during navigation, revealing spatial and temporal receptor profiles that enable discrimination of repulsive signals.

Stereotyped Terminal Axon Branching of Leg Motor Neurons Mediated by IgSF Proteins DIP-α and Dpr10

The paper shows that DIP-α and Dpr10 IgSF proteins mediate stereotyped terminal axon branching of leg motor neurons in Drosophila through interactions between axon filopodia and muscles.

Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity in Drosophila

TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

This study shows TIAM-1/GEF shapes dendrites in C. elegans by regulating F-actin localization without requiring its GEF activity.

The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the Drosophila Nervous System

This review discusses how Teneurin proteins use conserved mechanisms to regulate diverse developmental processes in the Drosophila nervous system, including axon guidance, partner matching, and synapse formation.

Formation of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

This study identifies Reelin's role in promoting fast, laterally-directed migration of midbrain dopaminergic neurons through stabilization of leading processes and induction of bipolar morphology.

Robo1 and 2 repellent receptors cooperate to guide facial neuron cell migration and axon projections in the embryonic mouse hindbrain

This study investigates the roles of Robo1 and Robo2 in facial neuron migration and axon projection in mouse embryos, finding that their loss leads to migration and projection defects.

Oculomotor nerve requires an early interaction with muscle precursors for nerve guidance and branch patterning

The paper shows that muscle precursors guide oculomotor nerve growth and branching in mouse embryos by acting as intermediate targets.

Distinct CED-10/Rac1 Domains Confer Context-Specific Functions in Neuronal Development

The paper identifies a specific glycine residue in CED-10/Rac1 that is critical for axon outgrowth but not guidance, revealing domain-specific functions in neuronal development.

A specific Ret receptor isoform is required for pioneer axon outgrowth and growth cone dynamics

This study identifies Ret51 as a marker for pioneer neurons and shows its role in axon growth and growth cone dynamics through retrograde transport.

Retinal Ganglion Cell Axon Sorting at the Optic Chiasm Requires Dystroglycan

This study shows that dystroglycan is essential for proper sorting of retinal ganglion cell axons at the optic chiasm, with missorted axons persisting into adulthood.

Ordered arrangement of dendrites within a C. elegans sensory nerve bundle

The paper quantifies dendrite arrangement in C. elegans and shows that cell adhesion molecules regulate their stereotyped order, which can be disrupted by genetic perturbations.

Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila

The paper shows that DIPs and Dprs control the organization of olfactory receptor neuron terminals in Drosophila by mediating class-specific self-adhesion and axon sorting.

Protocadherin-mediated cell repulsion controls the central topography and efferent projections of the abducens nucleus

The paper identifies protocadherin-mediated repulsion as critical for organizing the abducens nucleus's topography and neuromuscular connections in zebrafish.

Rap2 and TNIK control Plexin-dependent synaptic tiling in C. elegans

This study identifies Rap2 and TNIK as regulators of Plexin-dependent synaptic tiling in C. elegans, showing their role in restricting presynaptic assembly and forming tiled innervation.

UNC-6/Netrin and its Receptors UNC-5 and UNC-40/DCC Control Growth Cone Polarity, Microtubule Accumulation, and Protrusion

This paper investigates how UNC-6/Netrin and its receptors UNC-5 and UNC-40/DCC regulate growth cone polarity, microtubule organization, and protrusion during axon guidance in C. elegans.

Selective Filopodia Adhesion Ensures Robust Cell Matching in the Drosophila Heart

The paper investigates how selective filopodia adhesion mediated by adhesion molecules ensures robust cell matching in Drosophila heart development.

A neuronal MAP kinase constrains growth of a C. elegans sensory dendrite throughout the life of the organism

The paper identifies genes that constrain dendrite growth in C. elegans throughout life, revealing a mechanism distinct from developmental growth pathways.

The Class I E3 Ubiquitin Ligase TRIM67 Modulates Brain Development and Behavior

This study shows that TRIM67 is critical for brain development and behavior, with deletion causing anatomical and functional impairments in mice.

Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

The paper identifies key proteins involved in axon guidance disorders using systems biology tools and analyzes their molecular mechanisms.

The Atypical Rho GTPase CHW-1 Works With SAX-3/Robo to Mediate Axon Guidance in Caenorhabditis elegans

This study identifies CHW-1 as an atypical Rho GTPase involved in axon guidance in C. elegans, showing its genetic interaction with SAX-3 and requirement for proper axon pathfinding.

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation

This study identifies Cas adaptor proteins as essential for DRG axon fasciculation and substrate adhesion during peripheral nervous system development.

Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

The paper shows that starburst amacrine cells use homotypic contacts to initiate formation of a dendritic scaffold in the retina, which is critical for direction-selective circuitry.