Sperm and Testicular Function

This study identifies and characterizes the role of EIF2A in Drosophila spermatogenesis, showing its essential function in male fertility through genetic mutations.

The paper shows acute paternal Dexamethasone exposure alters sperm RNA and offspring metabolism, identifying circRNAs as novel RNA-mediated inheritance candidates.

This study compares transcriptomic and epigenomic changes in young and aged spermatogonial stem cells, identifying molecular alterations linked to aging and differentiation.

The paper investigates spermiogenic defects in Drosophila melanogaster SD/SD+ males and links them to Rsp satellite DNA copy number, showing how high Rsp levels trigger sperm elimination.

The paper shows that RNF8 is not required for histone-to-protamine exchange in spermiogenesis, contradicting a previous study.

This paper investigates the role of Topaz1 in murine spermatogenesis, showing it stabilizes testis-specific long non-coding RNAs and is critical for terminal differentiation but not essential for fertility.

The paper compares transcriptomes of fetal and adult Leydig cells in mice to identify gene expression differences and regulatory mechanisms of steroidogenesis.

This study identifies Tcf21+ mesenchymal progenitors in mouse testis that contribute to somatic cell development, homeostasis, and regeneration.

The paper shows that CTCF and BORIS work together in spermatogenesis, with their combined loss causing infertility due to defective meiosis and gene expression.

This study identifies CFAP53 as essential for sperm flagellum biogenesis, showing its role in male infertility and interactions with proteins in the manchette and sperm tail.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

The paper identifies KCTD19 as essential for meiotic exit in male mice, showing it interacts with ZFP541 and HDAC1, and its deficiency causes apoptosis during meiosis.

The paper identifies a germ cell-specific Mga variant mRNA that promotes meiotic entry by impairing non-canonical PRC1 function through alternative splicing.

This study shows that loss of pachytene piRNAs on chromosome 18 in mice causes sperm head abnormalities, infertility, and defects in acrosome formation and function.

The paper identifies a 1.6 Mb Y-chromosomal inversion in the AZFc region as a high-penetrant risk factor for male infertility, increasing the risk of spermatogenic failure by 8.6-fold.

The paper shows a lncRNA interacts with β-Spectrin to regulate spermatogenesis and endosomal processes in Drosophila fat bodies.

The paper uses single-molecule long-read sequencing to identify conserved long RNA profiles in sperm and reveals a post-transcriptional selection mechanism shaping these profiles in mice and humans.

The paper shows that sperm cooperation in mice forms clusters at the utero-tubal junction, facilitating oviduct entry and fertilization, with defects in this process linked to infertility.

This study shows that Rlim is essential for spermiogenesis in male mice, as its deletion leads to defective sperm production and fertility issues.

This study identifies SPE-18 as an intrinsically disordered protein essential for localized MSP assembly in C. elegans spermatocytes, revealing a novel strategy for cytoskeletal element sequestration.

The paper identifies BRDT binding sites in gene units during spermatogenesis and links them to specific transcription factors and epigenetic features that regulate gene expression.

This study identifies gene expression trends and regulatory mechanisms during bovine spermiogenesis by comparing transcriptomes of round spermatids, elongated spermatids, and epididymal sperm with mouse data.

The paper identifies an intronic deletion in DNAH17 causing infertility in pigs due to defective sperm flagella by disrupting splicing and axoneme assembly.

The paper identifies piRNAs in porcine sperm and finds correlations between their abundances and semen quality traits, with many located near transposable elements and fertility-related genes.

The paper shows that apoptosis in the fetal mouse testis removes developmentally defective germ cell clones based on intrinsic properties and epigenetic states.

This study establishes an in vitro protocol to generate human prospermatogonia-like cells from induced pluripotent stem cells and characterizes their lineage trajectory using single-cell RNA-sequencing.

This study shows that MAFR-1, an RNA polymerase III regulator, affects sperm quality in C. elegans by influencing spermatid size and fertilization ability, with effects dependent on RNA pol III activity.

The paper shows that Sertoli-cell androgen signaling is not required for meiotic prophase initiation but is essential for meiotic division phase competence in spermatocytes.

The paper identifies a deletion in the BOLL gene in pigs causing defective acrosomes and subfertility.

The paper examines chromatin remodeling and gene expression dynamics in mouse spermatogonial cells across postnatal development using RNA-seq and ATAC-seq.