Liver Disease Diagnosis and Treatment

Liver Protein Expression in NASH Mice on a High-Fat Diet

This study examines protein expression changes in NASH mice on a high-fat diet with and without mineral supplementation, identifying early molecular alterations and protective effects of minerals.

Multi-omics approach reveals dysregulation of protein phosphorylation correlated with lipid metabolism in mouse fatty liver

The paper uses a multi-omics approach to analyze proteomic, phosphoproteomic, and lipidomic data from mouse livers to identify dysregulated protein phosphorylation and lipid metabolism in diet-induced obesity.

Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

This study identifies MIR20B as a regulator of PPARA in NAFLD, showing its role in lipid metabolism and potential as a therapeutic target.

Deciphering the genetic links between NAFLD and co-occurring conditions using a liver gene regulatory network

The paper constructs a liver-specific gene regulatory network to identify genetic links between NAFLD and co-occurring conditions, revealing shared regulatory mechanisms.

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

The paper uses machine learning to quantify liver fat from MRI data and identifies genetic variants associated with liver fat accumulation and related diseases.

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting

This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.

Identification of hub genes and pathways in nonalcoholic steatohepatitis by integrated bioinformatics analysis

The paper identifies hub genes and key pathways in nonalcoholic steatohepatitis using integrated bioinformatics analysis of gene expression data.

Suppression of Fatty Acid Oxidation by Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance

This study shows that deleting Them2 in skeletal muscle reduces weight gain and improves glucose homeostasis on a high-fat diet, but does not prevent hepatic steatosis.

Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity

The paper identifies distinct enhancer signatures in NASH-prone and NASH-resistant human obesity patients, revealing key genes and pathways associated with resistance.

Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts.

This study investigates the role of Mcpip1 in obesity-induced hepatic steatosis using myeloid and liver-specific conditional knockouts, finding that myeloid depletion leads to systemic inflammation and metabolic dysregulation, while liver-specific depletion has less impact.

Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in nonalcoholic fatty liver disease

The paper identifies AGXT2 as a gene with an anti-fibrotic effect in NAFLD through eQTL screening and functional validation.

Hepatic steatosis and steatohepatitis: a functional metaanalysis of sex-based differences in transcriptomic studies

This paper performs a meta-analysis of transcriptomic studies to identify sex-based differences in molecular mechanisms during the progression from NAFL to NASH.

Computational hypothesis: How Intra-hepatic functional heterogeneity may influence the cascading progression of free fatty acid-induced non-alcoholic fatty liver disease (NAFLD)

The paper develops a mathematical model to show how intra-hepatic functional heterogeneity drives the progression of free fatty acid-induced NAFLD through cascading failure.

TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models

The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.

Combined Metabolic Activators decrease liver steatosis by activating mitochondrial metabolism in a Golden Syrian hamster study

Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver

This study shows chronic IL6 overexpression in zebrafish causes liver fat accumulation through glycolysis deregulation, suggesting inflammation as a cause for obesity-independent NAFLD.

Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation

This study shows that PCK1 deficiency worsens NASH by activating the PI3K/AKT/PDGF axis, leading to fibrosis and inflammation.

The impact of PNPLA3 and TM6SF2 in cirrhosis related complications

This study examines the role of PNPLA3 and TM6SF2 polymorphisms in cirrhosis-related complications, finding significant associations in NAFLD patients but not in others.

Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis

The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

This study develops machine learning models to predict liver fat content using multi-omic and clinical data from NAFLD patients, achieving higher accuracy than existing tools.

Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease

This study investigates miR-379 as a biomarker for NAFLD, finding it upregulated in patients and correlated with cholesterol levels.

The effect of liver enzymes on body composition: a Mendelian randomization study

This paper uses Mendelian randomization to investigate the effect of liver enzymes on body composition, finding inverse associations between ALT and fat mass.

IL-11 neutralising therapies target hepatic stellate cell-induced liver inflammation and fibrosis in NASH

This study identifies IL-11 as a key driver of HSC-to-myofibroblast transformation in NASH, showing that targeting IL-11 reduces fibrosis and inflammation in preclinical models.

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD

This study compares gene expression changes in rodent models of methyl donor deficiency with human NAFLD, finding limited similarity but shared inflammatory and fibrotic pathways.