Ion channel regulation and function

This study shows HCN channels modulate mAHP amplitude and firing gain in fast alpha motoneurons, with no effect on slow motoneurons.

This study identifies Ser353/Pro245 as the key structural determinant for ligand selectivity differences between KCa2.2 and KCa3.1 channels using computational methods.

This study investigates the functional role of the a3 isoform of Na,K-ATPase in neuronal excitability and spiking dynamics using biophysically detailed models.

This study identifies a volatile anaesthetic binding site in voltage-gated sodium channels, showing it modulates channel function and reduces neuronal excitability.

This study uses a knock-in mouse model to analyze native ENaC complexes in different tissues, revealing tissue-specific differences in channel abundance and complex size.

This study determines the cryo-EM structure of TASK-1 at low pH and shows how protonation of an extracellular histidine leads to channel closure, with mutations affecting proton sensitivity.

The paper uses molecular dynamics simulations and electrophysiology to study conformational changes in TMEM16A upon inhibitor removal, revealing conductive and non-conductive states and mechanisms of Ca2+-dependent gating.

The paper identifies and classifies ion channels across species, revealing functional insights into understudied CALHM channels through sequence, structure, and functional data integration.

This study assesses α-α-subunit interactions of Nav1.5 in a heterologous expression system and finds that interactions depend on N-linked glycosylation and non-native disulfide bonds.

This study shows lipid bilayers enable cooperative cAMP binding to HCN channels but do not affect intrinsic binding affinity, revealing a role for membranes in enhancing inter-subunit interactions.

This study identifies a pressure-sensitive regulatory mechanism of L-type Ca2+ channels that influences cerebral blood flow control and cognitive function.

This study shows that a single-point mutation in Kir2.1 channels protects mice from diet-induced obesity by altering fat distribution and increasing energy expenditure.

This study uses fluorescent noncanonical amino acids to measure conformational changes in hHv1, showing Zn2+ induces reversible FRET changes.

The paper develops a unified deep non-linear mixed effects model for voltage-gated potassium channels, improving fit over existing models and enabling modeling of diverse channel types.

This paper uses molecular dynamics simulations to compare how RY785 and TEA inhibit Kv2.1 channels, showing RY785 stabilizes a semi-open gate state while TEA blocks the pore.

This study identifies eight structurally diverse KCNT1 channel inhibitors through virtual screening and experimental validation, offering potential new treatments for KCNT1-associated epilepsy.

This study shows that Kv1.3 palmitoylation regulates its spatial distribution and removal from the immunological synapse, impacting T cell activation and autoimmune disease.

This study identifies PHM-2 as a regulator of synaptic transmission in C. elegans by modulating SLO-2 potassium channel activity through posttranscriptional control.

This study determines the structure of a pH-sensitive ion channel from the scabies mite and shows how ivermectin modulates its activity through pH-dependent conformational changes.

This study identifies a KCNC1 variant linked to Rett syndrome that disrupts ER to Golgi trafficking of Kv3.1 channels, affecting neuronal excitability.

This study shows chlorpromazine inhibits EAG1 channels by disrupting PAS-CNBH domain coupling, without affecting VSD movement.

This study identifies Ca-alpha1T and Slowpoke channels as essential for pro-tumorigenic Ca2+ signaling in Drosophila gliomas, with Slowpoke showing therapeutic potential.

This paper shows that stomach muscles of Cancer borealis hyperpolarize with warming and operate optimally within a narrow pH window, mediated by K2P channels that reduce excitability and maintain neuromuscular function under environmental change.

The paper demonstrates how neurons use dual-timescale regulation of ion channel properties to achieve persistent adaptation to environmental perturbations.

This study investigates how functionality and trafficking of KCNQ2/3 K+ channels are coupled, showing that low-activity mutations disrupt AIS targeting via ankyrin-G interaction.

This study investigates how cholesterol modulates HCN channels in DRG neurons through sequential membrane remodeling, showing distinct effects in naive and neuropathic conditions.

This study shows that the γ1 subunit of BK channels increases the equilibrium constant for channel opening by destabilizing the closed state and enhancing voltage-sensor-pore coupling.

This study shows that the TWK-26/KCNK3 potassium channel and FLR-4 protein kinase work together in C. elegans to regulate nutrient absorption and metabolic homeostasis.

This study presents a cryo-EM structure of human Nav1.5 in an intermediate open state, revealing a new Na+ binding site and showing ion binding modulates IFM motif docking and inactivation kinetics.

The paper uses molecular dynamics simulations to analyze the KCNQ2 G256W variant, revealing structural changes in the pore domain that disrupt ion selectivity and contribute to epileptic encephalopathy.