Herpesvirus Infections and Treatments

This study tests a prime/pull/keep HSV-1 vaccine in HLA-A*0201 transgenic rabbits, showing it reduces corneal herpes infection by mobilizing and retaining CD8+ T cells in infected tissues.

This study shows HSV-1 gC shields gD from neutralizing antibodies, increasing viral susceptibility to antibody neutralization when gC is absent.

This paper shows that simultaneous loss of pUL16 and pUL21 in HSV-1 infected cells prevents cytoplasmic envelopment of viral capsids.

This study uses 3D correlative fluorescence and X-ray tomography to analyze HSV-1 mutants, revealing roles of viral proteins in morphogenesis and showing envelopment occurs via budding.

This paper develops a novel murine ex vivo skin explant model to study HSV-1 infection and spread in intact skin, showing HSV-1 exclusively spreads in the epidermis through infected keratinocytes.

This study investigates VZV gene repression in neuronal cells, finding that histone deposition is absent at quiescent viral genomes.

This study shows that asymptomatic neonatal HSV infection in mice causes long-term cognitive impairment, highlighting the role of the γ34.5 gene in neurovirulence.

This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.

This paper identifies the HUSH-SETDB1-MORC2 complex as essential for maintaining HSV-1 latency by promoting H3K9me3 chromatin marks on viral genomes in neurons.

This study identifies NAMPT's phosphoribosyl-hydrolase activity as a mechanism to restrict HSV-1 infection by de-phosphoribosylating viral structural proteins.

This study shows that culturing primary neurons at physiological oxygen levels (5%) improves neuronal health and reduces HSV-1 reactivation without affecting latency establishment.

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

The paper shows that lytic gene promoters in HSV-1 are active during latency only when located near the LAT locus.

This paper develops a fur plucking model to induce HSV-1 and HSV-2 reactivation in mice, enabling study of recurrent disease mechanisms and therapeutic interventions.

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

HerpesDRG provides a database and tools for drug resistance mutation analysis in human herpesviruses using genotype-phenotype literature.

This paper identifies phosphorylation sites in HSV-2 pUL21 and shows that phosphorylation is required for secondary envelopment of nucleocapsids and virus replication.

This study compares alphaherpesvirus vhs proteins to determine if translational arrest and mRNA decay are separate functions, finding that some induce mRNA decay while others cause translational arrest without decay.

This study identifies how BoHV-1 UL49.5 protein hijacks the C-degron pathway to promote TAP degradation via the CRL2 E3 ligase.

This study uses drop-based microfluidics to analyze HSV-1 infection in neurons, showing that replication kinetics vary with inoculating dose.

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

This study determines the structure of the HSV-1 ICP0 dimer domain, revealing a novel β-barrel fold and its interactions with SUMO1.

This study identifies hyperfusogenic mutations in HSV-1 glycoproteins gB, gD, and gH/gL from strain ANG, showing their role in enhanced membrane fusion and entry.

This study shows c-Jun signaling during HSV-1 initial infection promotes latency and enhances later reactivation by facilitating the transition from Phase I to Phase II reactivation.

The paper presents ancient HSV-1 genomes from Europe, estimates mutation rates, and suggests lineage replacement during the Bronze Age.

This study identifies US3 kinase's role in promoting retrograde transport of nucleocapsids in axons via Akt/mToRC1 signaling during alpha herpesvirus infection.

This study identifies ICP22 as a viral repressor of cellular RNA polymerase II transcription elongation by interacting with elongation factors, and suggests VP16 may compete with ICP22 for these factors.

This study shows that HSV-1 protein ICP4 both activates and represses host gene transcription by modulating RNA polymerase II occupancy and promoter pausing.

This study shows that the Us9 protein of pseudorabies virus regulates axonal sorting differently in immature versus mature neurons, with immature neurons showing reduced Us9-dependent sorting and increased Us9-independent transport.

The paper reports a case of HSV mistyping caused by HSV-1 x HSV-2 recombination in the UL27 gene, which is important for diagnostics and therapeutics.