Antimicrobial Peptides and Activities

Environmental Control of Antimicrobial-to-Amyloidogenic Switching in Uperin 3.5 by Surfactant Assembly Dynamics

This study investigates how surfactant charge and assembly dynamics regulate the antimicrobial-amyloidogenic transition of Uperin 3.5, showing charge-dependent structural stabilization and aggregation behavior.

Antimicrobial Peptides Induce Cell Death in Marginal Zone Lymphoma Models Resistant to Targeted Therapies

This study evaluates the antitumor activity of seven natural antimicrobial peptides against MZL cell lines and resistant derivatives, finding W-trematocine and temporin L show potent cytotoxicity with low toxicity to non-malignant cells.

MetaPepticon: automated prediction of anticancer peptides from microbial genomes and metagenomes

MetaPepticon automates the discovery of anticancer peptides from microbial genomes and metagenomes, identifying 79,587 novel candidates including 13,149 high-confidence, non-toxic peptides.

Granulysin-Based pH-Sensitive Antimicrobial Nanocarriers for Treatment of Multidrug-Resistant Bacterial Wound Infections

This paper develops pH-sensitive nanocarriers for granulysin to treat multidrug-resistant bacterial infections, showing effective antimicrobial activity and reduced inflammation in a mouse model.

Generative Deep Learning and Molecular Dynamics Reveal Design Principles for Amyloid-Like Antimicrobial Peptides

This paper introduces amyAMP, a deep learning framework that generates antimicrobial peptides with amyloid-like properties, validated through molecular dynamics simulations.

Engineered antimicrobial-derived peptides to manipulate mixed microbial systems

This paper develops molecular probes to manipulate specific subpopulations in microbial communities using bacteriocins and validates them in synthetic populations.

Identification of Human Gut Microbiome Derived Peptides Targeting Biofilm Specific Lectin Proteins of Pseudomonas aeruginosa

This study identifies human gut microbiome-derived antimicrobial peptides that target Pseudomonas aeruginosa biofilm-specific lectins, showing potent antibiofilm activity.

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

Optimizing histatin 5: Effects of K13 and K17 substitutions on proteolytic stability and antifungal activity

This study investigates how substitutions at positions K13 and K17 in histatin 5 affect its proteolytic stability and antifungal activity against Candida albicans.

Integrative Multi-Scale Sequence-Structure Modeling for Antimicrobial Peptide Prediction and Design

This paper introduces MultiAMP, a framework for predicting and designing antimicrobial peptides by integrating sequence and structural information, achieving state-of-the-art performance and discovering novel peptides.

The Bacteriocin Sublancin Restores Vancomycin efficacy against vancomycin-resistant enterococci in vitro and in vivo

This study shows that sublancin, a bacteriocin, enhances vancomycin's effectiveness against vancomycin-resistant enterococci in vitro and in vivo by down-regulating resistance genes.

Serum modulates the aggregation - toxicity landscape of the staphylococcal toxin PSMα3

This study shows serum lipoproteins inhibit PSMα3 aggregation and cytotoxicity by preventing oligomer and fibril formation, revealing a general mechanism of amyloid peptide toxicity.

SET-M33 peptide as a selective in vitro antimicrobial agent against the porcine respiratory pathogen Glaesserella parasuis

This study evaluates the antimicrobial peptide SET-M33 against Glaesserella parasuis and porcine commensals, showing its selectivity and potential for in vitro use.

An unusual ring pattern in the Rosβ lanthipeptide of the two-component lantibiotic roseocin

This study determines the unique ring pattern of the Rosβ lanthipeptide of roseocin using NMR spectroscopy and Marfeys analysis.

Modulation of the human cathelicidin dimerization interface separates antimicrobial activity from mammalian membrane disruption

This study identifies residues critical for separating antimicrobial activity from membrane disruption in LL-37 by modulating its dimerization interface.

Investigation of Regulation and Binding Patterns of the Human Cathelicidin Peptide LL-37 in Complexation with Nucleic Acids, and its Impact on Neutrophil Extracellular Traps

This study investigates how LL-37 binds to nucleic acids, forming complexes that affect DNA structure and NET clearance, with implications for immune regulation and disease.

Division-arrest induced filamentation protects uropathogenic Escherichia coli from killing by the cathelicidin antimicrobial peptide LL-37

This study shows that LL-37 kills dividing E. coli by disrupting membranes during late division, while filamentation confers resistance, suggesting filamentation may aid UPEC survival during infections.

AMPBAN: A Deep Learning Framework Integrating Protein Sequence and Structural Features for Antimicrobial Peptide Prediction

AMPBAN is a deep learning model that integrates protein sequence and structural features to predict antimicrobial peptides, showing superior performance compared to existing methods.

Hemolytik2: An Updated Database of Hemolytic Peptides and Proteins

Hemolytik2 is a manually curated database of hemolytic and non-hemolytic peptides with detailed annotations and structural information.

Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective

This paper characterizes abaecin-2, a hymenopteran HDP with copper-binding properties that can inhibit or protect bacteria depending on context.

Modes of action and in planta antifungal activity of Olea europaea defensin OefDef1.1-derived peptide variant

This study evaluates a synthetic peptide variant derived from olive defensin OefDef1.1, showing antifungal activity against Botrytis cinerea through membrane permeabilization, vacuolar accumulation, and protein synthesis inhibition.

Tryptophan-substitution antimicrobial peptide temporin-1CEb: in vitro and in vivo antibacterial activity against clinically isolated multidrug-resistant Klebsiella pneumoniae

This study evaluates Trp-substituted antimicrobial peptides against multidrug-resistant K. pneumoniae, finding that I1WL5W shows superior antibacterial activity, reduced cytotoxicity, and effective biofilm disruption and therapeutic efficacy in a murine model.

AntiFP2: Genome and Metagenome-Wide Prediction of Antifungal Proteins

AntiFP2 predicts antifungal proteins from genomic and metagenomic data using an ensemble of ESM2, BLAST, and MERCI, achieving high accuracy through cross-validation and offering a scalable pipeline.

Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins

This study identifies the C-terminal domain (CTD) of BSAP-1 as the receptor-binding region, showing its role in specificity and potential for developing new tools.

Amphibian-derived peptide analog TB_KKG6K: A powerful drug candidate against Candida albicans with anti-biofilm efficacy

This study identifies TB_KKG6K, an amphibian-derived peptide, as a potent antifungal agent effective against Candida albicans planktonic cells and biofilms, with no adverse effects on standard antifungal drugs.

Design of highly potent anti-biofilm, antimicrobial peptides using explainable artificial intelligence

This study designs potent anti-biofilm antimicrobial peptides using an explainable AI framework, achieving high efficacy against MRSA biofilms.

New potential antimicrobial peptides with amazing symmetrical structure in fungi and insects

The paper identifies a new family of antimicrobial peptides, HLPs, with a unique symmetrical structure found in fungi and some insects, suggesting potential applications in medicine and food preservation.

Induction and antiviral activity of human β-defensin 3 against adenovirus and influenza A virus in vitro infection of human airway epithelial cells

This study shows that respiratory viruses like adenovirus and influenza A virus induce hBD-3 expression in human airway cells and that recombinant hBD-3 inhibits both viruses in vitro.

A global deep-sea small protein atlas reveals a reservoir of noncanonical antimicrobial peptides

The paper constructs a deep-sea small protein atlas, identifies noncanonical antimicrobial peptides, and demonstrates their antimicrobial efficacy and non-lytic mechanisms.

Bad bugs, new drugs: The antimicrobial peptide C14R is active against the ESKAPE pathogens

This study evaluates the antimicrobial peptide C14R against ESKAPE pathogens, showing potent bactericidal activity and biofilm inhibition.