Exercise and Physiological Responses

Development of a mouse model to investigate the effect of exertional heat stress on skeletal muscle

This study develops a mouse model of exercise-induced whole body hyperthermia that mimics skeletal muscle injury features observed in heat stress.

Erythrocyte extravasation drives ferroptosis and inflammatory amplification in eccentric contraction-induced skeletal muscle injury via the heme-HO-1-iron axis

This study investigates how erythrocyte extravasation contributes to skeletal muscle injury via the heme-HO-1-iron axis, linking it to ferroptosis and inflammation.

Cardiorespiratory fitness and sex impact the colorectal cancer-suppressive effects of aerobic exercise serum

This study shows that cardiorespiratory fitness and sex influence how exercise serum affects colorectal cancer cell viability.

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

Proteome Profiling of Human Tear Fluid Following Acute Exercise

This study identifies proteome-wide changes in human tear fluid after acute exercise, revealing upregulated translation-related proteins and downregulated glycan metabolism proteins.

Gene III(R) L-Ergothioneine Ameliorates Exercise-Induced Fatigue by Attenuating Oxidative Stress, Inflammation, and Modulating the AMPK/PGC-1α Signaling Pathway

This study shows that Gene III(R) EGT improves exercise performance and reduces fatigue in mice by lowering oxidative stress, inflammation, and activating the AMPK/PGC-1α pathway.

Bioimpedance spectroscopy assessment of skeletal muscle tissue properties after muscle damage

This study assesses if bioimpedance spectroscopy can detect eccentric exercise-induced muscle damage and correlate with functional and mechanical impairments.

N-Acetylcysteine Partially Rescues Heat-Stressed Skeletal Muscle Cells: A Secondary Analysis of Public Data

This study analyzes public data to assess N-acetylcysteine's protective effects against heat stress in skeletal muscle cells, finding partial protection at 2.0 mM with a large effect size.

Multi-omics Profiling Identifies Molecular and Cellular Signatures of Regular Physical Activity in Human Peripheral Blood

This study identifies molecular and cellular signatures of regular physical activity in human peripheral blood using multi-omics profiling, revealing enhanced metabolic and immune functions.

Multi-platform plasma proteomics reveals orthogonal metabolic signatures distinguishing elite athletic phenotypes

This study uses multi-platform plasma proteomics to identify metabolic signatures distinguishing elite athletes' acute and chronic exercise adaptations.

Transcriptomic analysis of 40 human and rodent skeletal muscle exerkines

The paper analyzes skeletal muscle transcriptomic responses to exercise in humans, mice, and rats to identify conserved and species-specific exerkine regulation patterns.

Quercetin activates the SIRT6-Nrf2 axis during oxidative stress, modulating ageing-associated markers in healthy men

This study investigates quercetin's effects on oxidative stress and DNA damage responses in healthy men during exercise, showing increased nuclear localization and gene expression related to DNA repair and antioxidant pathways.

Exercise intensity modulates the human plasma secretome and interorgan communication

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

Salivary Biomarkers for Classifying Acute Physical Fatigue: A Comparative, Exploratory Study

This study compares targeted and untargeted salivary biomarkers for classifying acute physical fatigue, finding that combining both improves classification accuracy.

Body Fluid Proteomic Landscape of Acute Exercise

This study maps the proteomic changes in plasma, saliva, and urine after acute exercise, identifying over 3,000 regulated proteins and their associations with disease and drug targets.

Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

A glucosinolate-rich beverage lowers blood lactate concentrations during submaximal exercise

This study shows that consuming glucosinolate-rich red kale sprouts reduces blood lactate during submaximal cycling and increases resting blood glucose.

Exercise induces anti-inflammatory reprogramming in macrophages via Hsp60

This study shows exercise induces anti-inflammatory reprogramming in macrophages via Hsp60, identified through secretome analysis and proteomic profiling.

Global multi-omics analysis of exerkines in progressive treadmill-exercised rodents

The paper analyzes exerkine responsiveness in exercised rodents using multi-omics data to identify tissue-specific and sex-dimorphic responses.

Ultra-small Particle Size Nanobubbles Water Drinking Exerts Antifatigue Effects in Chronic Exercise Fatigue Rats via Improving Antioxidative Activities

This study shows that Ultra-small Particle Size Nanobubbles Water improves antioxidant activity and physical performance in chronically fatigued rats.

Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

This study compares the effects of moderate and vigorous exercise on intestinal damage, stress response, inflammation, and gut microbiota in mice, finding that daily moderate exercise causes more severe injury than vigorous training with rest days.

No effect of menstrual cycle phase on eccentric exercise-induced neuromuscular impairments and the magnitude of the repeated bout effect

This study found no effect of menstrual cycle phase or oral contraceptive use on neuromuscular impairments after eccentric exercise or the repeated bout effect.

Organism-wide secretome mapping uncovers pathways of tissue crosstalk in exercise

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

Dynamic Transcriptomic Network Responses to Divergent Acute Exercise Challenges in Young Adults

The paper compares transcriptomic responses in skeletal muscle and extracellular vesicles after traditional and high-intensity exercise in young adults, finding more consistent gene responses to traditional exercise and unique microRNA responses to high-intensity training.

Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

The paper shows that plasma from exercising mice reduces brain inflammation and improves memory, with clusterin as a key anti-inflammatory factor also elevated in human exercisers.