Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Understanding Complex Chromatin Dynamics of Primary Human Neutrophils During PMA Induced NETosis

The paper examines chromatin dynamics in primary human neutrophils during PMA-induced NETosis, identifying early chromatin changes linked to NOX-dependent NET formation.

Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury

This study shows that loss of neutrophil Shp1 causes severe lung injury and death in mice, and that activating Shp1 can reduce inflammation and lung damage.

Novel regulator Fpr2 controls immune homeostasis via CCL4-dependent neutrophils

This study identifies Fpr2's role in immune homeostasis by regulating neutrophil subpopulations via CCL4 and Anxa1, revealing mechanisms of bacterial resistance.

HOCl Forms Lipid N-Chloramines in Cell Membranes of Bacteria and Immune Cells

The paper shows HOCl forms lipid N-chloramines in bacterial and immune cell membranes, which oxidize proteins and are neutralized by glutathione, suggesting a role in inflammation and immune response.

Zfp263 is a transcriptional checkpoint of neutrophil development

This study identifies Zfp263 as a key transcriptional regulator in neutrophil development, showing it represses ERK1/2 signaling and controls differentiation and effector function acquisition.

Differential action modes of Neutrophil Extracellular Trap-targeted drugs define T cell responses in SARS-CoV-2 infection.

This study compares how two NET-targeting drugs, rhDNase and GSK484, affect T cell responses in SARS-CoV-2 infection, showing differing impacts on adaptive immunity.

Neutrophil extracellular traps formation and deposition of fibrin and von Willebrand factor during human coronary atherogenesis

This study examines the presence and extent of neutrophil extracellular traps (NETs), fibrin, and von Willebrand factor (VWF) in different stages of human coronary atherosclerosis, finding that NETs are rare in stable plaques but increase in unstable ones.

MACROPHAGES COORDINATE IMMUNE RESPONSE TO LASER-INDUCED INJURY VIA EXTRACELLULAR TRAPS

The paper investigates how macrophages/monocytes coordinate immune responses to laser-induced retinal injury through extracellular traps, showing that inhibiting ETosis improves retinal repair.

Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO

This study shows MPO enters endothelial cell nuclei, binds chromatin non-enzymatically, and regulates EndMT and EC fate through chromatin remodeling and interaction with ILF3.

Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli

The paper identifies a FOXP4-driven transcriptional network in human neutrophils responding to inflammatory stimuli, including LPS, and shows its regulation of proinflammatory genes.

Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA

This paper demonstrates that neutrophil extracellular traps (NETs) are a major source of mono-N cirDNA independent of apoptosis, and shows that NE and MPO contribute to NET autocatabolism and cirDNA release.

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation

The paper presents a multi-omic analysis of mouse neutrophils, identifying age and sex-related differences in chromatin regulation and predicting increased neutrophil elastase release in males.

Defective NET Clearance contributes to sustained FXII Activation in COVID-19-associated Pulmonary Thrombo-Inflammation

A map of gene expression in neutrophil-like cell lines

The paper compares gene expression in HL-60 and PLB-985 cell lines before and after differentiation to primary neutrophils, finds DMSO-based protocols are effective, and creates a gene expression database.