Axon Guidance and Neuronal Signaling

Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis

This study identifies two distinct roles of Plexin A in Drosophila medulla development: one for neuropil morphogenesis requiring its cytoplasmic domain and another for layer formation via Semaphorin 1a.

Cadherin 4 assembles a family of color-selective retinal circuits that respond to light offset.

This study identifies cadherin 4 as a key molecule for layer-specific targeting of retinal ganglion cells in sublaminae 1 and 3a, affecting their connectivity and visual responses.

Stochastic growth and selective stabilization generate stereotyped dendritic arbors

The paper shows that dendritic growth is stochastic and ligand-free, while ligand binding inhibits growth and specifies shape in C. elegans neurons.

hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit

This study identifies hkb as a regulator of DIP- expression and target recognition in specific Drosophila motor neurons, revealing distinct transcriptional control mechanisms.

UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.

This study identifies UNC-16's role in axon termination through interactions with LRK-1 and WDFY-3, highlighting the endolysosomal system's involvement.

Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling

This study shows Tet regulates axon guidance in Drosophila brain development via glutamatergic signaling, with Gs2 as a key mediator.

Combinatorial expression of neurexin genes regulates glomerular targeting by olfactory sensory neurons

The paper identifies neurexin gene expression patterns in olfactory sensory neurons that guide axonal targeting to specific glomeruli through interactions with neuroligins in mitral/tufted cells.

Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres

The paper identifies topographic principles in the corpus callosum that guide axon connectivity between brain hemispheres through symmetric adhesion molecule levels and co-fasciculation.

Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

This study shows that Sema3E-Plexin-D1 signaling activates Mtss1 to coordinate axonal extension and steering during neuronal pathfinding.

Phosphorylation of PLPPR3 membrane proteins as signaling integrator at neuronal synapses

The paper identifies phosphorylation sites in PLPPR3 and shows that phosphorylation at S351 regulates its interaction with BASP1, suggesting a role for the PLPPR3-BASP1 complex in synaptic signaling.

Eph/ephrin signalling in the developing brain is regulated by tissue stiffness

This study shows that tissue stiffness regulates Eph/ephrin signalling in the Xenopus optic pathway, with mechanical gradients correlating with EphB and ephrinB expression patterns.

EphB1 controls proper long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells

This study shows that EphB1 in GABAergic neurons is essential for guiding cortical glutamatergic axons during brain development by preventing them from following blood vessels.

Optogenetic Regulation of EphA1 RTK Activation and Signaling

This study designs and tests an optogenetic EphA1-Cry2 fusion to selectively activate EphA1 signaling without ligand, characterizing MAPK phosphorylation as a key signaling target.

Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation

This study identifies non-redundant roles of Plexin-B1 and Plexin-B2 in GABAergic synapse formation through structure-function analysis and presynaptic expression studies.

An analysis of semaphorin-mediated cellular interactions in the C. elegans epidermis using the IR-LEGO single-cell gene induction system

The paper investigates how semaphorin signaling regulates cell shape in C. elegans epidermis using mosaic gene expression analysis with IR-LEGO.

Neuronal wiring receptors Dprs and DIPs are GPI anchored and this modification contributes to their cell surface organization

This study shows that Drosophila Dpr and DIP proteins are GPI anchored, and this modification is necessary for their cell surface organization and function.

Bilateral retinofugal pathfinding impairments limit behavioral compensation in near-congenital one-eyed Xenopus laevis

This study examines retinotectal projections and visuomotor behavior in one-eyed Xenopus laevis, finding impaired pathfinding and behavioral compensation.

Qualitative Observations of Transgenically Individualized Serotonergic Fibers in the Mouse Telencephalon

The paper qualitatively describes individually-tagged serotonergic axons in mouse telencephalic regions using Brainbow labeling and confocal microscopy.

Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina

This study shows that Sema6A, expressed by retinal ganglion cells, is essential for delineating OFF and ON functional domains in the inner plexiform layer of the mouse retina.

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub

The paper identifies genetic and proteomic interactions between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub in C. elegans neurons, showing their role in axon development and neurodevelopmental disorders.

Generation and characterization of Sema6aΔcyt conditional knockout mice

This study generates a conditional knockout mouse model to investigate the physiological role of SEMA6A reverse signaling in nervous system development, revealing its importance in axon pathfinding and neuron migration.

Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata

The paper investigates axonal development in Basket cells, finding that axons from dendrites develop higher complexity than those from cell bodies, influenced by spontaneous activity.

RhoGDI phosphorylation by PKC regulates its interaction with death receptor p75NTR to gate axon growth and neuron survival pathways

The paper shows how ligand-directed competition between RIP2 and RhoGDI for p75NTR engagement determines axon growth and neuron survival.

Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

This study identifies drebrin's role in regulating axon branching in cortical neurons and develops tools to analyze single-cell morphology.

MAP1B Regulates Cortical Neuron Interstitial Axon Branching Through the Tubulin Tyrosination Cycle

This study identifies GSK3β's role in promoting interstitial axon branching in cortical neurons by modulating MAP1B and the tubulin tyrosination cycle.

Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance

The paper identifies Cables1 as a linker protein that connects Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance during spinal cord development.

Activation of Multiple Eph Receptors on Neuronal Membranes Correlates with The Onset of Traumatic Optic Neuropathy

This study identifies Eph receptor activation in postnatal mouse retinas and shows its correlation with traumatic optic neuropathy onset and neuroprotective effects upon inhibition.

Development of prefrontal corticostriatal connectivity in mice

This study investigates the development of prefrontal corticostriatal connectivity in mice, showing that axons target their zones early and synapses do not undergo extensive pruning, with Cdh8 playing a role in behavioral outcomes.

Wnt signaling and contact-mediated repulsion shape sensory dendritic fields

The paper investigates how Wnt signaling and contact-mediated repulsion regulate dendritic field sizes in C. elegans sensory neurons.

Axon guidance during CNS regeneration is required for specific brain innervation

This study shows that axon guidance defects prevent functional recovery in CNS regeneration and that suppressing Slit/Robo signaling enables axons to reinnervate the SCN, leading to behavioral recovery.