Axon Guidance and Neuronal Signaling

Non-autonomous Vnd acts with autonomous Appl during mushroom body axon growth in Drosophila

This study shows that vnd is more critical than Appl for MB axon outgrowth, with vnd acting non-autonomously.

Identifying determinants of synaptic specificity by integrating connectomes and transcriptomes

The paper identifies synaptic specificity determinants by integrating connectomes and transcriptomes in Drosophila.

Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure

This study shows that prenatal alcohol exposure disrupts interhemispheric cortical connectivity by altering miR-17-5p regulation of axon guidance, leading to behavioral deficits in mice.

Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration

This study shows human retinal ganglion cells (hRGCs) use chemotropic cues for axon guidance and regeneration, involving Netrin-1/DCC signaling and mTOR pathway activation.

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans.

This paper identifies a short isoform of the UNC-5 receptor in C. elegans that is required for dorsal growth cone polarity and protrusion, distinct from the long isoform's inhibitory role.

Rejection of inappropriate synaptic partners mediated by transcellular FLRT2-UNC5 signaling

The paper shows that FLRT2-UNC5 signaling mediates synaptic partner rejection in retinal neurons by eliminating dendrites that stray from their correct sublayers.

Gbx2 controls amacrine cell dendrite stratification through Robo1/2 receptors

This study shows that Gbx2 regulates dendritic stratification of amacrine cells via Robo1/2 receptors and Slit1/2 ligands in the mouse retina.

Robo1 loss has pleiotropic effects on postnatal development and survival

This study examines the postnatal effects of Robo1 loss in mice, finding slower growth, shorter lifespan, and altered skin and hair characteristics.

Axon onset remodeling in response to network activity in mouse cortical neurons

The paper shows that mouse cortical neurons can change their axon origin from somatic to dendritic and vice versa in response to network activity changes.

Conserved atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory sensory neurons

This study identifies Fat2 as a regulator of axon terminal organization in Drosophila olfactory sensory neurons, showing its role in glomerulus formation and axon retraction.

bII-spectrin is required for synaptic positioning during retinal development

This paper identifies {beta}II-spectrin's role in positioning pre- and post-synaptic neurons during retinal development, leading to synaptic connectivity defects and impaired visual function.

Subcellular second messenger networks drive distinct repellent-induced axon behaviors

The paper shows that repellent cues ephrin-A5 and Slit1 induce spatially segregated second messenger signals, controlling distinct axonal behaviors.

WFIKKN2 is a bifunctional axon guidance cue that signals through divergent DCC family receptors

The paper identifies WFIKKN2 as a bifunctional axon guidance cue that repels sensory axons via Nope and attracts motor axons through other DCC family receptors.

LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity

This study shows that LTK and ALK regulate neuronal polarity and migration by modulating IGF1R activity, leading to behavioral abnormalities when disrupted.

The scheduling of adolescence with Netrin-1 and UNC5C

This study shows that Netrin-1 and UNC5C guide dopamine axon growth during adolescence, with environmental cues affecting their timing in a sex-specific manner.

Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila

The paper investigates the role of Ena/VASP proteins in axon growth by analyzing filopodial morphology and actin organization in Drosophila neurons.

SRC-1 controls growth cone polarity and protrusion with the UNC-6/Netrin receptor UNC-5 in Caenorhabditis elegans

This study investigates the role of SRC-1 in growth cone polarity and protrusion in C. elegans, showing it acts with UNC-5 in these processes.

Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons

The paper identifies Collagen XV-B and Tenascin C as ECM components guiding motor axon growth through their dual topology and stiffness in zebrafish.

Slit-independent guidance of longitudinal axons by Drosophila Robo3

This study shows that Drosophila Robo3 guides longitudinal axons without requiring Slit, despite needing its Ig1 domain for Slit binding and axonal localization.

A cell-type-specific nitric oxide-cGMP pathway regulates proprioceptor morphology

The paper shows that the NO-cGMP pathway, regulated by the transcription factor Cut, influences the morphology of proprioceptors in Drosophila.

Cis mutagenesis in vivo reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring

The paper uses cis mutations in Dscam1 to show noncanonical roles of isoform diversity in neuronal wiring, revealing distinct phenotypic defects in different neuron types.

BDNF signaling in correlation-dependent structural plasticity in the developing visual system

This study investigates BDNF signaling's role in structural plasticity during visual system development by manipulating neural activity correlation and observing axonal branch dynamics in Xenopus laevis tadpoles.

TOM-1/Tomosyn acts with the UNC-6/Netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans

This study shows that TOM-1 inhibits growth cone protrusion by regulating vesicle fusion, working with UNC-5 to restrict protrusion in C. elegans.

The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation in Drosophila

This study identifies the role of the zinc-BED transcription factor Bedwarfed in regulating dendritic growth and branching through transcriptional and translational mechanisms in Drosophila.

Complex Formation of Immunoglobulin Superfamily Molecules Side-IV and Beat-IIb Regulates Synaptic Specificity in the Drosophila Visual System

The paper identifies Side-IV/Beat-IIb as a cell-surface complex that regulates synaptic specificity by narrowing binding specificity and recruiting synapse formation factors.

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

This study shows that Lphn2's role in axon targeting depends on context-specific G protein coupling and autoproteolytic cleavage.

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

The paper shows that palmitoylation of neuropilin-2 is necessary for its localization and function in cortical neurons, and that different palmitoyl acyltransferases regulate its and neuropilin-1's roles in semaphorin signaling.

Regulated alternative splicing of Dscam2 is required for somatosensory circuit wiring

This study shows that regulated alternative splicing of Dscam2 ensures proper synaptic partner selection in the larval somatosensory system by preventing inappropriate connections.

Local microtubule and F-actin distributions fully determine the spatial geometry of Drosophila sensory dendritic arbors

Cbln1 directs axon targeting by corticospinal neurons specifically toward thoraco-lumbar spinal cord.

This study identifies Cbln1 as a molecular regulator directing thoraco-lumbar axon extension by corticospinal neurons, showing its sufficiency but not necessity for this targeting.