Psychedelics and Drug Studies

Simulated 5-HT2A receptor activation accounts for the high complexity of brain activity during psychedelic states

The paper presents a biophysically-based model simulating 5-HT2A receptor activation effects, showing increased spontaneous complexity and altered spectral power without significant change in perturbational complexity.

Psilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA)

This study examines psilocybin's effects on social behavior and inflammation in female mice under different stress conditions, finding context-dependent changes in novelty-seeking and IL-6 levels.

The impact of the serotonergic psychedelic DOI on active vision in freely moving mice

This paper investigates how the psychedelic DOI affects visual processing in mice by analyzing neural activity in V1 during naturalistic vision and gaze shifts.

Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling.

This study investigates the effects of the psychedelic 5-HT2A receptor agonist DOI on neuronal activity, hemodynamics, and neurovascular coupling in mice using wide-field optical imaging.

Intravenous Administration of Serotonergic Psychedelics Produce Short-lasting Changes in Sleep-Wake Behavior and High Gamma Functional Connectivity in Rats

This study examines the effects of intravenous psilocybin and DMT on sleep-wake states and EEG functional connectivity in rats, finding short-term changes in sleep patterns and increased high gamma coherence.

Gestational LSD exposure in mouse rapidly reaches embryonic CSF and is associated with altered choroid plexus signaling, cerebral cortical development, and offspring behavior

This study shows maternal LSD exposure in mice rapidly reaches embryonic cerebrospinal fluid, activates choroid plexus, and leads to cortical and behavioral changes in offspring.

Trauma Under Psychedelics: How Psychoactive Substances Impact Trauma Processing

This study examines how psychoactive substances affect trauma processing in survivors of a mass attack, finding that MDMA reduced distress and improved sociality, while Cannabis and Alcohol increased distress and worsened sleep.

Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans

This study investigates the effects of the psychedelic DOI on C. elegans behavior, finding that it inhibits feeding independently of serotonin receptors, suggesting alternative mechanisms.

Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice

This study examines the cardiovascular effects of microdosing LSD in mice and finds no significant risk despite 5-HT2B receptor activation.

Context-dependent structurally informed effective connectivity under psilocybin

This study examines how structural connectivity shapes brain dynamics under psilocybin using effective connectivity models and fMRI data across different contexts.

Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis

Open-source DeepLabCut pose tracking plus SimBA random forest classifiers detect mouse head twitches from video at F1 95.51 (50% resolution, 120 fps), rivaling magnetometer methods.

Age- and estrous-dependent effects of psilocybin in rats

This study examines age- and estrous-dependent effects of psilocybin in rats, finding no long-term behavioral changes after adolescent exposure but differences in head twitch responses.

Psilocybin Prolongs the Neurovascular Coupling Response in Mouse Visual Cortex

This study shows psilocybin prolongs neurovascular coupling in mouse visual cortex, affecting blood flow without altering neural responses, and suggests implications for interpreting human neuroimaging data.

A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity

This study shows that psychedelics induce neuroplasticity through a reciprocal interaction between 5-HT2A and mGlu5 receptors involving Shank3.

Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models

This study shows psilocybin does not have analgesic effects in acute or chronic mouse pain models across various pain types and doses.

Increased 5-HT2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

Synergistic Behavioral and Neuroplastic Effects of Psilocybin-NMDAR Modulator Administration.

This study combines psilocybin with NMDAR modulators to enhance therapeutic effects and reduce adverse effects in mice, showing improved neuroplasticity and reduced hallucinogenic and antipsychotic-like behaviors.

LSD Restores Synaptic Plasticity in VTA of Morphine-Treated Mice and Disrupts Morphine-Conditioned Place Preference

Effects of serotonergic psychedelics on synaptogenesis and immediate early genes expression - comparison with ketamine, fluoxetine and lithium

This study compares the neuroplastic effects of psilocin, LSD, DMT, ketamine, fluoxetine, and lithium on synaptogenesis and immediate early gene expression in rat cortical cultures.

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

This study shows psilocybin enhances fear extinction by altering cortical neural ensembles, with acute suppression of fear-active neurons and delayed recruitment of extinction-active neurons.

Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.

Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach

This study uses multimodal imaging to show ketamine increases glutamate in the ACC and alters brain network connectivity, suggesting potential long-term neuroplastic effects.

Ayahuasca Shifts Brain Dynamics Toward Higher Entropy: Persistent Elevation of Ising Temperature Correlates with Acute Subjective Effects

This study uses fMRI and the Ising model to show ayahuasca increases brain entropy, with subacute effects correlating with acute subjective experiences.

Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience.

This study uses network control theory to show DMT reduces brain control energy, correlates with EEG entropy and subjective experience, and links these effects to serotonin 2a receptor distribution.

Speech markers of psychedelic-induced psychological change

This study analyzes speech and vocal features before and after 5-MeO-DMT to identify markers of psychological change and predict outcomes.

PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour

PsiConnect investigates psilocybin's effects on brain and behavior using multimodal neuroimaging and longitudinal follow-ups.

A multi-institutional investigation of psilocybin's effects on mouse behavior

This study investigates psilocybin's effects on mouse behavior through a multi-laboratory collaboration, finding robust acute effects but inconsistent persistent effects.

The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State

This study uses fMRI and MEG to investigate how LSD affects DLPFC connectivity and relates to ego dissolution and emotional arousal in healthy humans.

LSD reconfigures the frequency-specific network landscape of the human brain

This study uses MEG data to show LSD reconfigures brain network frequencies and spatial distributions in specific frequency bands across different experimental conditions.

Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

The paper shows psilocybin promotes lasting social behavior in autism models, which is reversed by DNA methyltransferase inhibition.