Psychedelics and Drug Studies

Psilocybin acutely reduces low-frequency BOLD power and frequency-specific connectivity

This study shows psilocybin reduces low-frequency BOLD power and alters frequency-specific connectivity in the brain.

Whole-brain drug distribution profiles of psychedelic drugs provide insights into rapid antidepressant action

The paper develops anatomical distribution profiles of psychedelic and anaesthetic drugs to understand their rapid antidepressant effects by combining pharmacodynamic data with receptor density maps.

When the psychedelic state's over: limited evidence for persistent neurophysiological changes in naturalistic psychedelic users

This study finds no significant neurophysiological differences in long-term psychedelic users compared to non-users, challenging the notion of persistent changes after abstinence.

Wherefore the magic? The evolutionary role of psilocybin in nature

This study investigates the evolutionary role of psilocybin by testing its effects on Drosophila development and behavior, finding developmental stress and reduced survival but no receptor-specific response.

Psilocybin Attenuates Cortical Representations of Aversion in the Mouse Auditory Cortex

This study shows psilocybin reduces established aversive sensory representations in the mouse auditory cortex without affecting new aversive learning or general auditory processing.

Ibogaine is associated with reorganization of high-beta brain networks in veterans with post-traumatic stress disorder

This study shows that ibogaine treatment in PTSD veterans is linked to reorganization of high-beta brain networks, which correlates with symptom improvement.

Electrophysiological Mechanisms of Psychedelic Drugs: A Systematic Review

This paper reviews electrophysiological studies on psychedelics, showing complex effects on neuronal excitability and synaptic transmission, challenging the idea of uniform cortical excitation.

Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Electrophysiological effects of psilocybin co-administered with midazolam

This study examines EEG changes during psilocybin and midazolam co-administration, finding increased beta power and decreased spectral exponent early on, and increased LZCn and spectral exponent later, suggesting psilocybin effects persist despite midazolam.

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model.

This study shows that a single dose of DMT reverses depressive-like behaviors and cognitive deficits in a mouse model of depression by restoring neurogenesis.

Psilocybin rapidly, but not immediately, reverses reward learning deficits in a durable manner in an inflammatory rat model of depressive symptoms

Psilocybin reverses reward learning deficits in a rat model of depression within 24 hours, with effects lasting at least 7 days.

Autonomic Indicators of Self-Transcendence: Insights from the Numadelic VR Paradigm

This study uses heart rate variability during numadelic VR to identify autonomic indicators of self-transcendent experiences and links them to affective outcomes.

Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seq

This study uses single-nucleus RNA-seq to show psilocybin induces cell-type-specific genetic and functional changes in the orbitofrontal cortex neurons.

Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin

This study uses connICA to analyze resting-state fMRI data and identifies distinct functional connectivity traits associated with psilocybin's effects on brain networks and cognitive performance.

Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex

This study shows psilocybin reduces reward-seeking behavior and increases activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex in rats.

A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery

This study investigates the synergistic effects of psilocybin and compassion imagery on cognitive absorption, self-compassion, and brain network activity using fMRI and self-report measures in 105 participants.

The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice

This study shows that the 5-HT1BR receptor mediates some behavioral and neural effects of psilocybin in mice, including reduced anhedonia and anxiety-like behavior.

Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats

This study investigates the neurochemical and neurophysiological effects of DMT in rats, finding dose-dependent increases in serotonin and dopamine and changes in EEG power and functional connectivity.

Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects

This paper uses a whole-brain model to simulate how serotonergic psychedelics affect brain dynamics in Alzheimer's disease, showing restored oscillatory patterns and correlation with serotonin receptor distribution.

Network Rerouting Under Ayahuasca: Temporally and Hemisphere-Resolved EEG Connectomics

The paper uses EEG and machine learning to analyze how functional brain networks reorganize after ayahuasca, finding decreased hub influence and increased distributed pathways in the right hemisphere.

N, N-Dimethyltryptamine and harmine formulation shifts metastable topography sequences in the cortex

This study investigates how a psychedelic formulation affects neural dynamics, finding increased metastability and structured reorganization of brain states.

Psilocybin induces sex- and context-specific recruitment of the stress axis

This study shows psilocybin activates hypothalamic stress-related neurons, with stronger effects in female mice and context-dependent changes in threat assessment.

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

Quantitative phosphoproteomics uncovers the signalling dynamics of hallucinogenic psychedelics

This study uses quantitative phosphoproteomics to show that hallucinogenic psychedelics induce distinct global phosphorylation patterns compared to non-hallucinogenic analogues, with functional relevance to glycolytic metabolism.

A Mesoscale Framework for Psychedelic Drug Action in the Human Brain

This study investigates how five psychedelic drugs affect local brain synchrony and global functional connectivity using fMRI, finding disrupted local synchrony and enhanced global connectivity across all drugs.

Psilocybin alters visual-contextual computations

This study investigates how psilocybin affects visual-contextual computations using psychophysics, fMRI, and computational modeling, finding altered perception and cortical responses.

A virtual clinical trial of psychedelics to treat patients with disorders of consciousness

This study uses computational models to simulate psychedelic treatments for disorders of consciousness, finding they shift brains closer to criticality, with varying effects based on patient state.

Ketamine and Psilocybin Differentially Impact Sensory Learning During the Mismatch Negativity

This study compares the effects of ketamine and psilocybin on sensory learning using EEG and computational modeling, finding distinct neural impacts on precision and volatility in auditory mismatch negativity.

Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects

This study examines how LSD and MDMA affect striato-cortical connectivity in healthy subjects using resting-state fMRI, finding distinct changes in connectivity patterns between the striatum and other brain regions.

Characterizing psilocybin as an antidepressant for adolescence in male and female rats

This study investigates psilocybin's antidepressant effects in adolescent rats, finding rapid and sustained effects in males but shorter and dose-dependent effects in females.