Planarian Biology and Electrostimulation

PCP components control anterior and posterior regeneration, with a Prickle homolog impacting muscle organization, in the acoel Hofstenia miamia

This study identifies PCP pathway components, pk-1 and dgo-1, as essential for anterior and posterior regeneration in Hofstenia miamia, with pk-1 affecting muscle organization and gene expression in tail fragments.

Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii

The paper generates a high-quality reference transcriptome for Platynereis dumerilii and analyzes RNA-seq data from posterior regeneration stages to identify gene expression dynamics and key molecular mechanisms.

Segmentation in tapeworms as a modified form of flatworm posterior regeneration involving Wnt and Hedgehog signalling

The paper investigates Wnt and Hedgehog signaling in tapeworm segmentation, finding that segments form through secondary AP axes linked to neuromuscular systems and regeneration mechanisms.

BMP suppresses WNT to integrate patterning of orthogonal body axes in adult planarians.

This study shows that BMP signaling suppresses Wnt signals to integrate anteroposterior and mediolateral patterning in adult planarians, revealing integrated axis control during regeneration.

Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights from Aged and Juvenile Limbs

The paper identifies key genes involved in regeneration in axolotl limbs by comparing transcriptomic data from juvenile and aged axolotls.

Ets-1 transcription factor regulates glial cell regeneration and function in planarians

This study identifies Ets-1 as a regulator of glial cell regeneration and function in planarians, revealing its role in maintaining nervous system architecture and behavior.

Limb regeneration is blastema dependent in a ladybird beetle, Cheilomenes sexmaculata (Fabricius)

The paper investigates limb regeneration in ladybird beetles, finding that blastema formation is essential for regeneration, as amputation without blastema cells prevents limb redevelopment.

Ultrafast and long-range coordination of wound responses is essential for whole-body regeneration

The paper shows that injury triggers ultrafast Erk signal propagation in planarians, mediated by body-wall muscles, which is essential for regeneration.

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration

This study identifies Regeneration Initiating Cells (RICs) in Xenopus laevis tail regeneration using single cell and spatial transcriptomics, showing their role in initiating regeneration by modifying the extracellular matrix.

Egr-2 coordinates intestinal remodeling by promoting midline patterning and pharynx regeneration in planarians

This study identifies Egr-2 as a regulator of intestinal remodeling and pharynx regeneration in planarians, showing its role in midline patterning and tissue integration.

Heterotrimeric G proteins regulate planarian regeneration and behavior

This study identifies seven heterotrimeric G protein subunits that promote planarian regeneration and two subunits critical for anterior polarity re-establishment, while also finding five G proteins modulate behavior.

Genomic analyses reveal FoxG as an upstream regulator of wnt1 required for posterior identity specification in planarians

The paper identifies FoxG as an upstream regulator of wnt1 involved in posterior identity specification during planarian regeneration through genomic analyses.

A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration of Form and Function in Biological Organisms

The paper proposes a conceptual and computational framework for regeneration of form and function in biological organisms, demonstrating its ability to restore anatomical and bioelectric homeostasis in an in silico model.

Failure of digit tip regeneration in the absence of suggests Lmx1b functions disparate from dorsoventral polarity

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

On the hormonal control of posterior regeneration in the annelid Platynereis dumerilii

This study shows that brain hormones, specifically methylfarnesoate, are essential for posterior regeneration in Platynereis dumerilii, and their absence after decapitation impairs regeneration.

Adult Drosophila legs do not regenerate after amputation

This paper replicates and refutes a claim that dietary supplements induce leg regeneration in Drosophila, finding no evidence of regeneration or regeneration-like structures.

PLANAtools - an interactive gene expression repository for the planarian Schmidtea mediterranea

PLANAtools provides an interactive repository for analyzing planarian gene expression data from over 160 studies, enabling users to generate plots and annotations without requiring advanced computational expertise.

Planarian dorsoventral Netrins control a muscle midline signaling center and regulate blastema formation

The paper identifies a muscle midline signaling center regulated by dorsoventral Netrins and Bambi-2 in planarians, which controls blastema formation during regeneration.

High throughput expression-based phenotyping and RNAi screening reveals novel regulators of planarian stem cells

The paper uses high-throughput expression profiling and RNAi screening to identify novel regulators of planarian neoblast stem cells.

Regenerated crustacean limbs are precise replicas

The paper shows that regenerated crustacean legs in Parhyale precisely replicate the microanatomy, sensory function, and transcriptional profiles of uninjured legs.

Identification of putative enhancer-like elements predicts regulatory networks active in planarian adult stem cells

The paper identifies enhancer-like elements in planarian adult stem cells using epigenetic and expression data, and links them to regulatory networks involved in regeneration.

Fibrillarin-1 and Fibrillarin-2 are required for divergent cell lineage development in planarian homeostasis and regeneration

This study identifies two fibrillarin homologs in planarians and shows their distinct roles in cell lineage development and tissue regeneration.

Krüppel-like factor 4 is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians

This study shows that Klf4 is essential for germline and yolk cell development and regeneration from somatic stem cells in planarians.

Intestine-enriched apolipoprotein b orthologs are required for stem cell differentiation and regeneration in planarians

This study identifies two intestine-enriched apolipoprotein b orthologs in planarians that are essential for stem cell differentiation and regeneration by transporting lipids to target tissues.

Distinct gene expression dynamics in developing and regenerating limbs

This study compares gene expression dynamics during leg development and regeneration in Parhyale hawaiensis, finding distinct temporal patterns despite shared gene sets.

Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico

This paper characterizes a new planarian isolate, Girardia sp. (Guanajuato), at morphological, cellular, and molecular levels to identify unique traits and facilitate future comparisons.

Reactive Oxygen Species Signaling Differentially Controls Wound Healing and Regeneration

This study shows that reactive oxygen species (ROS) signaling differentially controls wound healing and regeneration in planarians by regulating distinct downstream targets.

Restoration of DNA Integrity and Cell Cycle by Electric Stimulation in Planarian Tissues Damaged by Ionizing Radiation

Electric stimulation restores DNA integrity and cell cycle in planarian tissues damaged by ionizing radiation through Ca2+ signaling and stem cell activation.

Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration

The paper identifies dynamic stem cell microenvironments in planarians that support regeneration by associating with diverse cell types.

Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis

This study identifies Src-1 as a factor that promotes robustness in planarian anteroposterior axis patterning by restricting head and trunk identities to anterior positions.