Diet, Metabolism, and Disease

The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice

This study examines how a high-fat, high-sucrose, and high-salt diet affects metabolic outcomes in mice, finding increased gonadal fat and glucose intolerance despite reduced inflammation.

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis

This study shows that dietary sulfur amino acid restriction improves glucose homeostasis by enhancing hepatic de novo serine synthesis through PSAT1, but not lipid metabolism.

Comparative metabolic profile of mice fed a grain-based controlled diet and a purified controlled diet

This study compares the metabolic profiles of C57BL/6 mice fed grain-based and purified diets under normocaloric conditions, finding no significant differences.

Effect of Western diet on body composition, locomotor performance and blood biochemical profile in the bank vole

This study examines the effects of Western diets on bank voles, finding resistance to obesity but altered liver function and metabolic pathways.

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

This study investigates the effects of JNK inhibition on metabolic dysfunction caused by sucrose overconsumption in rats using multi-tissue network analysis.

Consumption of human-relevant levels of sucrose-water rewires macronutrient uptake and utilization mechanisms in a tissue specific manner

This study shows that chronic sucrose water consumption in mice rewires tissue-specific molecular mechanisms, leading to systemic metabolic dysfunction including impaired glucose homeostasis and mitochondrial dysfunction.

Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.

This study shows that chronic nitrate supplementation in mice with diet-induced obesity worsens metabolic health and accelerates disease progression, including liver cancer.

Protein restriction associated with high fat induces metabolic dysregulation without obesity in juvenile mice

This study shows that a Western diet with protein restriction in juvenile mice causes metabolic dysregulation without obesity, including hyperglycemia and fatty liver.

Integrated Omics Analysis Reveals Sirtuin Signaling is Central to Hepatic Response to a High Fructose Diet

The paper integrates transcriptomics, proteomics, and metabolomics data from vervet monkeys to identify sirtuin signaling and PPARA network alterations in response to a high fructose diet.

Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice

This study examines how fructose affects metabolic and transcriptomic responses in genetically diverse mice, identifying strain-specific pathways and regulators involved in metabolic dysfunctions.

Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation

The paper investigates how excess dietary sugar and fat affect liver mitochondria protein acetylation and succinylation in mice through multi-omic profiling.