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An endoplasmic reticulum resident molecular chaperone, GRP170, prevents stress-induced glomerular injury

This study shows that GRP170 protects podocytes from stress-induced glomerular injury by modulating the UPR, as demonstrated in a podocyte-specific knockout mouse model.

THE MULTIFUNCTIONAL PROTEIN E4F1 REGULATES MELANOCYTIC FUNCTIONS IN MICE THROUGH PROTEIN TRANSLATION AND MITF EXPRESSION

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

Modified 3rd Generation Synchronization Modulation Electric Field (3m-SMEF) Prevents Ischemia-Reperfusion-Induced Acute Kidney Injury via Targeting Na⁺/K⁺-ATPase

The paper demonstrates that modified 3rd-generation SMEF (3m-SMEF) protects against ischemia-reperfusion-induced AKI by preserving Na/K-ATPase function and tubular integrity in vitro and in vivo.

A General Mathematical Model of Symport Based on Conformational Transitions

The paper develops a general mathematical model of symport based on conformational transitions, showing it fits experimental data from multiple transporter families and reveals mechanistic principles.

Voluntary wheel running selectively preserves skeletal muscle during pancreatic cancer cachexia despite persistent systemic alterations

This study compares voluntary wheel running and treadmill running in a pancreatic cancer model, finding that VWR preserves skeletal muscle while TR does not, despite similar systemic effects.

Epithelial function of the circadian clock gene, Bmal1, in regulating the mucosa.

This study shows that Bmal1 in colon epithelial cells promotes mucus production and is essential for sex-specific tissue regeneration after injury.

Loss of LanC-like proteins impairs post-injury regeneration of aging muscles

This study shows that LanCL proteins are essential for muscle regeneration in aging mice, as their loss impairs regeneration and increases inflammation.

There is an 'I' in team: Intrapersonal physiological synchrony complements interpersonal physiological synchrony in team interaction

The paper examines how intrapersonal and interpersonal physiological synchrony interact during team interactions, finding they complement rather than compete, and that intrapersonal synchrony has both state and trait characteristics.

Asymmetric listening conditions perturb verbal and nonverbal coordination dynamics during conversation

This study examines how asymmetric listening conditions affect verbal and nonverbal coordination in conversations, finding altered turn-taking and movement dynamics under noise.

A Translational Reference for Green Autofluorescence Imaging in the Rhesus Macaque Eye using the OcuMet Beacon

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

Sustained Maternal Cortisol Elevation Links Metabolic Stress to Fetal Growth Restriction in a Guinea Pig Model of Undernutrition

This study shows that maternal cortisol elevation due to stress mediates fetal growth restriction in undernourished guinea pigs, beyond just nutrient limitation.

An Injectable Antisense Oligonucleotide (ASO) Approach to Treat Obesity in Preclinical Models

This paper demonstrates that injectable antisense oligonucleotides (ASO) can prevent and treat obesity in mice without significant loss of lean mass.

Activation of perivascular thermogenic fat improves aortic stenosis

This study shows that activating perivascular thermogenic fat reduces aortic stenosis in mice and correlates with less severe AS in humans.

Dietary phosphorus restriction enables multigenerational breeding of α-Klotho-deficient rats

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

Molecular anatomy of the glomerular filtration barrier reveals topology-encoded albumin sieving

The paper uses cryo-ET and transport modeling to show that the glomerular basement membrane's void-network topology restricts albumin passage, explaining selectivity in the filtration barrier.

A Broad-Spectrum Chemokine Inhibitor Prevents Preterm Labor in Mice by Suppressing Inflammation Induced by Intra-Amniotic Injection of Interleukin-1 alpha

This study shows that BSCI prevents preterm labor in mice by reducing inflammation and uterine gene expression changes caused by IL-1.

Molecular responsiveness to testosterone is uncoupled from skeletal muscle mass and strength in males aged 18 - 80 years

This study shows that free testosterone is linked to skeletal muscle transcriptome changes but not to muscle mass or strength in males aged 18-80.

Human iPSC-Derived Cardiomyocytes Maladaptively Remodel to Cyclic Stretch in Hypoplastic Left Heart Syndrome

This study compares how HLHS patient-derived iPSC-CMs and control iPSC-CMs respond to cyclic stretch, finding impaired mechanoadaptation and heightened inflammation in HLHS cells.

Reduced physiological reserve and a blunted response to acute exercise in adults with cerebral palsy

This study identifies a distinct cardiometabolic profile and reduced physiological response to exercise in adults with cerebral palsy compared to typically developing individuals.

Channelrhodopsin Ion Selectivity Determines Mechanisms and Efficacy of Optogenetic Defibrillation in Human Atria and Ventricles

This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.