A. Chatterjee

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

This study identifies cell wall-associated molecules that confer phage resistance in E. faecium and shows that phage resistance mutations enhance antibiotic susceptibility and synergize with antimicrobials.

Genome-wide mutagenesis identifies factors involved in Enterococcus faecalis vaginal adherence and persistence

This study identifies bacterial factors important for Enterococcus faecalis vaginal colonization and persistence using a transposon mutagenesis screen in a mouse model.

Site-Specific Incorporation of Citrulline into Proteins in Mammalian Cells

This paper introduces a method to site-specifically incorporate citrulline into proteins in mammalian cells and demonstrates its utility by showing reduced activity of modified PAD4 variants.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition

This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Transcriptome-based design of antisense inhibitors re-sensitizes CRE E. coli to carbapenems

This study uses transcriptomics to identify gene targets for antisense inhibitors that re-sensitize CRE E. coli to carbapenems.

Parallel genomics uncover novel enterococcal-bacteriophage interactions

The paper uses genomic approaches to study how Enterococcus faecalis responds to phage infection, identifying transcriptional regulators and gene expression changes that influence bacterial fitness and community interactions.

Facile Accelerated Specific Therapeutic (FAST) Platform to Counter Multidrug-Resistance Bacteria

The paper introduces a FAST platform that rapidly develops therapies against multidrug-resistant bacteria using sequence-specific PNAs and a novel delivery system.

Generation of Recombinant Mammalian Selenoproteins through Genetic Code Expansion with Photocaged Selenocysteine

This paper develops a method to generate and activate recombinant mammalian selenoproteins using genetic code expansion with photocaged selenocysteine, bypassing SECIS elements and selenium dependency.

Enterococcus faecalis CRISPR-Cas is a robust barrier to conjugative antibiotic resistance dissemination in the murine intestine

This study shows that CRISPR-Cas in Enterococcus faecalis blocks antibiotic resistance plasmid dissemination in the mouse intestine but not in vitro.

Stress fiber growth and remodeling determines cellular morphomechanics under uniaxial cyclic stretch

This study investigates how stress fiber growth and remodeling affect cellular morphomechanics under uniaxial cyclic stretch, showing increased stiffness and reorientation.

Deciphering the mechanoresponsive role of β-catenin in Keratoconus epithelium

This study investigates β-catenin's role as a mechanotransducer in KC epithelium, finding altered expression, localization, and interactions associated with biomechanical changes.

Identification of lncRNAs associated with early stage breast cancer and their prognostic implications

This study identifies differentially expressed long non-coding RNAs in early-stage breast cancer and evaluates their prognostic significance using RNA sequencing and TCGA datasets.

Bacteriophage resistance alters antibiotic mediated intestinal expansion of enterococci

This study shows that phage resistance in enterococci reduces their intestinal colonization ability and antibiotic sensitivity, suggesting phage therapy could complement antibiotics in treating dysbiotic microbiota.

Multiple quantitative trait loci contribute tolerance to bacterial canker incited by Pseudomonas syringae pv. actinidiae in kiwifruit (Actinidia chinensis)

This study identifies multiple quantitative trait loci (QTLs) associated with tolerance to Pseudomonas syringae pv. actinidiae in kiwifruit, revealing genetic pathways involved in resistance.

Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids.

This study integrates epigenome, exome, and transcriptome data to identify molecular subtypes and homeotic transformation in uterine fibroids.

Galectin-1 promotes the invasion of bladder cancer urothelia through their matrix milieu

This study identifies Galectin-1 as a driver of bladder cancer invasion through matrix interactions, showing its role in promoting adhesion, proliferation, and mesenchymal-like phenotypes.

Design of a de novo aggregating antimicrobial peptide and bacterial conjugation delivery system

This paper designs a de novo aggregating antimicrobial peptide, OpaL, and develops a bacterial conjugation system to deliver the gene to target bacteria.

Feel the way with a vibrotactile compass: Does a navigational aid aid navigation?

This study tests if a vibrotactile compass aids navigation in complex indoor spaces, finding it improves orientation for external landmarks but not internal ones.

Making honey bees lie: experimental dissociation of flight experience and dance communication.

This study shows that honey bees update their dance duration after multiple foraging trips, suggesting two distinct memory contents for flight distance information.

Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

This paper develops a low-cost WGS method for TB diagnosis and surveillance using direct respiratory samples, achieving rapid results with high concordance with reference labs.