A. Kumar

Isolation and characterization of SARS-CoV-2 VOC, 20H/501Y.V2, from UAE travelers

The paper isolates and characterizes the SARS-CoV-2 VOC 20H/501Y.V2 (B.1.351) from UAE travelers to India to assess vaccine efficacy.

STING mediates immune responses in the closest living relatives of animals

This study shows that STING mediates antibacterial immunity in the choanoflagellate M. brevicollis, a close relative of animals, and identifies its role in pathogen sensing and autophagy.

SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locus

This study generates CCR5-edited T cells and macrophages from nonhuman primate iPSCs, showing resistance to SIV replication.

Immunoinformatics approach for a novel multi-epitope vaccine construct against spike protein of human coronaviruses

The paper designs a multi-epitope vaccine against human coronaviruses using in-silico tools, predicting epitopes and evaluating its antigenicity and immune response.

Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant

The paper examines the replication cycle and transcriptional patterns of the B.1.1.7 SARS-CoV-2 variant, finding higher expression of ORF6 and ORF8 and increased infectivity despite lower copy numbers.

Assessment of dependency and consumption pattern of different forest products by the forest fringe villages of Shivalik Himalaya, Uttarakhand, India

The paper assesses timber, fuelwood, and fodder consumption patterns in forest fringe villages of Uttarakhand, India, finding high local extraction and socio-economic determinants of dependency.

MHC-matched allogeneic bone marrow transplant fails to eliminate SHIV-infected cells from ART-suppressed Mauritian cynomolgus macaques

This study shows that MHC-matched allogeneic bone marrow transplants in ART-suppressed SHIV-infected macaques do not fully eliminate viral reservoirs, with persistent SHIV DNA in tissues and rebound after ART interruption.

NaCT (SLC13A5) facilitates citrate import and metabolism under nutrient-limited conditions

This study shows that NaCT-mediated citrate uptake supports cell survival under nutrient limitation and metal toxicity by enhancing metabolism and lipogenesis.

Modelling the efficacy of Neprilysin from various species in degrading different Amyloid-beta peptides: Potential application in therapeutics of Alzheimers disease

This study models neprilysin efficacy across species in degrading amyloid-beta peptides to inform Alzheimer's disease therapeutics.

Probable omnigenic effect and evolutionary insights of aerobic adaptation allele OsNCED2T on qDTY12.1 effecting grain yield under reproductive stage drought stress in rice

The paper investigates the omnigenic effect of the OsNCED2T allele on qDTY12.1 grain yield under drought stress in rice and proposes a breeding model for drought tolerance.

Structural basis of phosphorylation kinetics in the transcriptional activation domain (TAD) of c-Jun and insight of two new phosphorylation sites Ser58 and Thr62

The paper investigates the structural basis of phosphorylation kinetics in c-Jun's TAD and identifies two new phosphorylation sites.

Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

MITOCHONDRIAL GENOME REVEALS CONTRASTING PATTERN OF ADAPTIVE SELECTION IN TURTLES AND TORTOISES

The paper analyzes mitochondrial genomes of turtles and tortoises to compare adaptive selection patterns, finding stronger positive selection in turtles than tortoises.

Unravelling cotton RNAseq repositories to the fiber development specific modules and their alliance with the fiber-related traits

The paper analyzes RNAseq data from cotton to identify gene modules associated with fiber development stages and links them to fiber-related traits.

Innate Immune sensing of Influenza A viral RNA through IFI16 promotes pyroptotic cell death

This study shows that IFI16 senses Influenza A viral RNA, activates interferons and cytokines, and promotes pyroptotic cell death during infection.

SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particles

This study identifies SARS CoV-2 nucleoprotein as an enhancer of spike-pseudotyped lentiviral particle infectivity without increasing sensitivity to RBD-based neutralization.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

MicroRNA775 and target Galactosyltransferase (GALT9) module regulates recovery from submergence induced senescence by modulating SAGs in Arabidopsis thaliana

This study identifies miR775 and its target GALT9 as regulators of submergence-induced senescence recovery in Arabidopsis by modulating SAGs and ROS levels.

3D-Visualization of Amyloid-β Oligomer and Fibril Interactions with Lipid Membranes by Cryo-Electron Tomography

This paper uses cryo-electron tomography to visualize how different Aβ assembly forms interact with lipid membranes, revealing that oligomers and protofibrils disrupt membrane integrity while monomers and fibrils have minimal impact.

Environmental Dependence of the Structure of the C-terminal Domain of the SARS-CoV-2 Envelope Protein

This paper investigates how environmental factors affect the conformation of the C-terminal domain of the SARS-CoV-2 envelope protein, showing it transitions between disordered, membrane-bound, and amyloid states.

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

This study reprograms CRISPR-Cas13b to suppress SARS-CoV-2 replication and resist viral mutations by tolerating single-nucleotide mismatches.

Zika Virus Capsid Anchor Forms Cytotoxic Amyloid-like Fibrils

This study investigates the amyloid-forming propensity of the Zika virus Capsid-anchor (CA) peptide and shows it forms cytotoxic amyloid-like fibrils.

Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

Proximity Biotin Labeling Reveals KSHV Interferon Regulatory Factor Networks

This paper uses proximity labeling to identify KSHV vIRF-1 and vIRF-4 interacting proteins, revealing their roles in viral reactivation and innate immune regulation.

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

This study identifies the LigA surface protein's A11 domain as a key factor in Leptospira's ability to modulate host immune responses and evade complement-mediated killing.

Finding Pathogenic nsSNP's and their structural effect on COPS2 using Molecular Dynamic Approach

The paper evaluates 90 nsSNPs in COPS2 using computational tools and molecular dynamics to identify pathogenic mutations affecting protein structure and function.

Isolation and characterization of lumpy skin disease virus from cattle in India

This study isolates and characterizes Lumpy Skin Disease Virus (LSDV) from cattle in India, showing it is closely related to Kenyan strains and demonstrating alternative cell lines for virus isolation and propagation.

Conformational Dynamics of NSP11 Peptide of SARS-CoV-2 Under Membrane Mimetics and Different Solvent Conditions

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.

SARS-CoV-2 NSP1 C-terminal region (residues 130-180) is an intrinsically disordered region

This study investigates the conformational dynamics of SARS-CoV-2 NSP1 C-terminal region in isolation and under different solvent environments, finding it intrinsically disordered with conformational changes induced by SDS, TFE, and DOPC.