A. Sharma

InVitro Biocompatibility Evaluation of Acellular Porcine Dura mater Grafts and Native Dura

This study evaluates the biocompatibility of native and acellular porcine dura grafts using rat fibroblast cells, showing comparable viability, proliferation, and mechanical properties to native tissue.

Effect of hexanal treatment on fruit qualities and antioxidant activities on 'Umran' Indian jujube fruit during cold storage

Hexanal treatment at 0.20% improved physicochemical properties, maintained bioactive compounds, and extended shelf life of Indian jujube during cold storage.

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

This paper uses atomistic simulations to show that WT TbMscL expands without breaking its hydrophobic seal, while GOF mutants open quickly due to solvation of the de-wetted constriction.

Regional assessment of male murine bone exposes spatial heterogeneity in osteocyte lacunar volume associated with intracortical canals and regulation by VEGF

This study assesses regional differences in male murine bone lacunar volume, showing spatial regulation by VEGF in association with intracortical canals.

Understanding the Free Energy Landscape of Phase Separation in Lipid Bilayers using Molecular Dynamics

This paper introduces a method to directly measure the free energy of lipid phase separation using enhanced sampling and a novel collective variable in molecular dynamics simulations.

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.

Impact of urbanization on the taxonomic and functional diversity of spider assemblages in Guwahati City, Assam, India

This study examines how urbanization affects spider taxonomic and functional diversity in Guwahati, finding lower diversity and altered functional traits in urban areas compared to forests.

Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol

This study uses a multi-omics approach to investigate how paracetamol exposure affects neuronal differentiation of human embryonic stem cells, identifying dysregulated genes and chromatin changes linked to neurodevelopmental outcomes.

On the origin and evolution of the mosquito male-determining factor Nix

This study investigates the origin and evolution of the mosquito male-determining factor Nix across Culicinae subfamily species, finding it originated 133-165 MYA and evolved faster than related factors.

13C ENDOR Spectroscopy-Guided MD Computations Reveals the Structure of the Enzyme-Substrate Complex of an Active, N-linked Glycosylated Lipoxygenase

This paper uses 13C/1H ENDOR spectroscopy-guided MD simulations to determine the structure of an active fungal lipoxygenase-substrate complex, revealing evolutionary insights into enzyme function.

Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus.

This study shows that yellow fever virus pr retains high affinity for E at neutral pH, differing from other flaviviruses, and reveals a unique mechanism for pr release from mature particles.

Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression

The paper shows that Plasmodium ANKA parasites exhibit ECM-specific gene expression profiles that are activated only in susceptible hosts, indicating host influence on cerebral malaria outcomes.

Defining the Parameters to Improve Plant Regeneration with Developmental Regulators

This study identifies key parameters to optimize plant regeneration using developmental regulators in monocot and eudicot species.

Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models

This study analyzes temporal gene expression patterns of VEGF-A and VEGF-B in a murine SARS-CoV model, revealing dynamic changes and potential interactions with SARS-CoV-2 Spike protein.

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

Mapping of the bs5 and bs6 non-race-specific recessive resistances against bacterial spot of pepper

This study maps two recessive resistance genes, bs5 and bs6, against bacterial spot in pepper, aiding marker-assisted breeding and resistance mechanism understanding.

Fluid flow sensitizes bacterial pathogens to chemical stress

The paper shows that fluid flow increases bacterial sensitivity to chemical stress by altering H2O2 gradients and transcriptional responses in Pseudomonas aeruginosa and Staphylococcus aureus.

Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

This study identifies a selective loss of CD107a+ TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH on long-term ART, which can be reversed by TIGIT blockade.

The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses

This study shows that ELMO1 and NOD2 interact to control intestinal inflammation and bacterial clearance, with their dysfunction linked to Crohn's disease.

Bacterial Polyphosphates Induce CXCL4 and Synergize with Complement Anaphylatoxin C5a in Lung Injury

This study shows that long-chain bacterial polyphosphates induce CXCL4 release from macrophages and synergize with C5a to cause lung injury.

Microbiome response in an urban river system is dominated by seasonality over wastewater treatment upgrades

This study examines the impact of wastewater treatment upgrades on the microbiome of an urban river system over seven years, finding that seasonality, not the upgrades, dominated microbial community dynamics.

CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA

This study evaluates VAR2CSA-based placental malaria vaccines in Aotus monkeys, finding limited cross-reactivity and functional activity similar to human trials.

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

Birth and Death in Terminal Complement Pathway

This study investigates the evolutionary origins and loss of TCP genes, finding that the C6 gene arose through sequential domain gains and the C9 gene was lost in galliform birds.

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

CRISPR-Cas guided mutagenesis of chromosome and virulence plasmid in Shigella flexneri by cytosine base editing

This paper develops a CRISPR-Cas base editing method to generate targeted loss-of-function mutants in Shigella flexneri with high efficacy and throughput.

Large haploblocks underlie rapid adaptation in an invasive weed

This study identifies large haploblocks as key drivers of rapid local adaptation in Ambrosia artemisiifolia across different climates.

SARS-CoV-2 inactivation by human defensin HNP1 and retrocyclin RC-101

This study shows that human defensins HNP1 and RC-101 destabilize SARS-CoV-2 Spike protein and inhibit viral infection in cell culture.