A. Sharma

Oligomerization state of the functional bacterial twin arginine translocation (Tat) receptor complex

The paper determines the tetrameric structure of the Tat receptor complex in bacterial membranes using single molecule photobleaching analysis.

SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma

The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.

Plant growth and phytoactive alkaloid synthesis in Mitragyna speciosa (kratom) in response to varying radiance

This study evaluates how different lighting conditions affect kratom plant growth and alkaloid synthesis, finding that shaded greenhouse conditions increase certain alkaloid concentrations and total leaf alkaloid yield.

Enthalpic and Entropic Contributions to Interleaflet Coupling Drive Domain Registration and Anti-registration in Biological Membrane

The paper develops an analytical theory to explain domain registration and anti-registration in biological membranes by analyzing enthalpic and entropic contributions to interleaflet coupling.

miPEP858/miR858-MYB3-PSK4 module regulates growth and development in Arabidopsis

The paper identifies a regulatory module involving miR858, miPEP858a, MYB3, and PSK4 that modulates plant growth and development in Arabidopsis through auxin response regulation.

Structural and functional characterization of Rv0792c from Mycobacterium tuberculosis: identifying small molecule inhibitors against GntR protein.

This study characterizes Rv0792c, a GntR homolog from M. tuberculosis, identifies small molecule inhibitors, and reveals its role in stress adaptation and virulence.

Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication

This paper shows that open conformation of HIV-1 Env allows efficient use of rhesus CD4 and enhances SHIV replication in rhesus macaques.

Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.

This study shows CMV infection increases Th17 cells in renal grafts via CCL20, which correlates with Th1 cells and reduces Tregs, and IL-17A inhibition lowers Th17 cells without affecting antiviral Th1 cells.

Gestational insulin resistance is mediated by the gut microbiome-indoleamine 2,3-dioxygenase axis

This study identifies the gut microbiome-indoleamine 2,3-dioxygenase (IDO1) axis as a mediator of gestational insulin resistance in mice.

A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting Fas signaling

This study identifies HOTTIP's role in regulating miR-196b expression through chromatin remodeling, which promotes leukemogenesis by altering FAS signaling.

Assessing the Effectiveness of Mycorrhizal Inoculation on the Biochemical Composition of the Different Species of Echinacea

This study evaluates how mycorrhizal inoculation affects the biochemical and physiological traits of three Echinacea species, finding that E. purpurea shows the most significant improvements.

Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

The paper identifies TRIM37 as a key mediator of growth arrest after PLK4 inhibition and shows that growth arrest correlates with PLK4 activity rather than mitotic length or centrosome number.

Recurrent erosion of COA1/MITRAC15 demonstrates gene dispensability in oxidative phosphorylation

The paper shows recurrent gene loss and structural changes in COA1/MITRAC15 in species with glycolytic muscle fiber dominance, linking it to oxidative phosphorylation dispensability.

Differential analysis of pesticides biodegradation in soil using conventional and high-throughput technology

The paper identifies a bacterial isolate capable of degrading multiple pesticides and shows its potential for bioremediation in contaminated soil.

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.

The males of the parasitoid wasp, Nasonia vitripennis, can identify which fly hosts contain females.

This study shows that male Nasonia vitripennis can detect female-specific cuticular hydrocarbons to identify fly hosts containing adult females, revealing a unique mate-finding strategy.

Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication

This study screens kinase inhibitors to identify compounds that block SARS-CoV-2 replication by targeting key cellular signaling pathways.

Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Chronic JUUL aerosol inhalation in mice alters inflammatory states in brain, lung, heart, and colon, with flavor-dependent effects and potential long-term health risks.

Discovery of photosynthesis genes through whole-genome sequencing of acetate-requiring mutants of Chlamydomonas reinhardtii

The paper sequenced genomes of photosynthesis mutants in Chlamydomonas reinhardtii to identify candidate genes involved in photosynthesis, validating two essential genes and uncovering 273 high-confidence candidates.

An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein

This paper develops an all-solid-state heterojunction oxide transistor for rapid, real-time detection of biomolecules and SARS-CoV-2 spike S1 protein at attomolar concentrations.

Minimal system for assembly of SARS-CoV-2 virus like particles

The paper demonstrates the assembly of non-infectious SARS-CoV-2 virus-like particles using viral proteins S, M, and E in mammalian cells, showing their structural stability and potential for vaccine development.

Structural stability of SARS-CoV-2 degrades with temperature

This study shows that SARS-CoV-2 structural stability decreases with temperature, supporting the seasonal pattern of viral infectivity.

Screening of tomato seed bacterial endophytes for antifungal activity reveals lipopeptide producing Bacillus siamensis as a potential bio-control agent

This study screens tomato seed bacterial endophytes for antifungal activity, identifying Bacillus siamensis as a potent bio-control agent producing lipopeptides effective against fungal pathogens.

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

IL-27 enhances the lymphocyte mediated innate resistance to primary hookworm infection in the lungs

This study shows IL-27 reduces hookworm infection and lung damage by enhancing lymphocyte responses in mice.

E-cigarettes compromise the gut barrier and trigger gut inflammation

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

Harvest and Culture of Porcine Adipose-Derived Mesenchymal Stem Cells for Autologous Transplantation

The paper describes a method for harvesting and isolating porcine adipose-derived mesenchymal stem cells (ADSCs) that are functionally equivalent to human ADSCs without sacrificing the donor animal.

DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.

Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells

This study shows that chromatin behaves like a solid on the mesoscale both in vitro and in living cells, with solid-like properties maintained despite limited fiber interactions.

PCNA has specific functions in regulation of metabolism in haematological cells

The paper shows that inhibiting PCNA's cytosolic scaffold function reduces glycolytic metabolites and nucleoside phosphate pools specifically in haematological cancer cells, suggesting a role in metabolic regulation.