A. Singh

Determinants of Viscoelasticity and Flow Activation Energy in Biomolecular Condensates

This study investigates the molecular factors controlling viscoelasticity and flow activation energy in biomolecular condensates using engineered polypeptides and DNA.

Exact distribution of the quantal content in synaptic transmission

The paper derives the exact distribution of quantal content in synaptic transmission for different AP input patterns and validates it with electrophysiological data from mice.

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain

The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.

Capturing long-tailed individual tree diversity using an airborne multi-temporal hierarchical model

The paper develops a multi-temporal hierarchical model to improve rare tree species classification in airborne imagery, achieving 75% accuracy for 14 species and generating species maps for over 670,000 trees.

Stress Combinations and their Interactions inPlants Database (SCIPDb): A one-stop resource for understanding combined stress responses in plants

SCIPDb is a database that compiles phenome and transcriptome data on plant responses to combined stresses, identifying novel genes and pathways involved in stress tolerance.

Dynamics and consequences of the HTLV-1 proviral plus-strand burst

This study uses live-cell imaging and mathematical modeling to analyze Tax expression dynamics in HTLV-1 infected T-cells, revealing heterogeneous patterns and impacts on cell behavior.

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-based in silico model using single-cell mechanomics

This paper develops an in silico model of trabecular bone remodeling in aging mice, showing how changes in OPG, RANKL, and Scl levels affect bone volume fraction.

Targeting the host protein G3BP1 for the discovery of novel antiviral inhibitors against Chikungunya virus

This study identifies seven small molecules that inhibit Chikungunya virus replication by targeting the G3BP1 protein's FGDF binding pocket.

Pyrophosphoproteomics: extensive protein pyrophosphorylation revealed in human cell lines

This study identifies endogenous protein pyrophosphorylation in human cell lines using a tailored pyrophosphoproteomics workflow, revealing its role in rDNA transcription regulation.

The N-terminal domain of the human mitochondrial helicase Twinkle has DNA binding activity crucial for supporting processive DNA synthesis by Polymerase γ

HIV-1 Vpr induces ciTRAN to prevent transcriptional silencing of the provirus

This study identifies ciTRAN, a circular RNA induced by HIV-1 Vpr that sequesters SRSF1 to enhance viral transcription.

Cell growth rates coordinate across the width of the leaf to remain flat

The paper analyzes cell growth dynamics in Arabidopsis leaves to show that coordinated growth across the leaf blade is necessary for maintaining flatness, and that the jaw-D mutant disrupts this coordination.

YAP/TAZ inactivation with simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction

This study shows that simvastatin reduces YAP/TAZ activity and ECM dysfunction in glucocorticoid-treated human trabecular meshwork cells.

Deep phylotaxonogenomic revision of the genus Xanthomonas within family Xanthomonadaceae and proposal of novel family Frateuriaceae within order Xanthomonadales

The paper revises the genus Xanthomonas and proposes a new family Frateuriaceae based on deep phylo-taxonogenomic analysis of the order Xanthomonadales.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia

This study identifies platelet phosphatidylserine as a critical mediator of thrombosis in heparin-induced thrombocytopenia and shows that blocking it prevents thrombus formation.

Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

The paper challenges the stochastic model of IFN-I response initiation by showing transient heritability and quorum sensing influence in early antiviral responses.

Modeling cell size regulation under complex and dynamic environments

The paper models cell size regulation as a stochastic process under dynamic environments and predicts how cell size and division strategy change with nutrient depletion.

Impaired baroreceptor reflex sensitivity in pelvic suspension rats is associated with sympathovagal imbalance but not with carotid artery structural change

This study shows that 15 days of hindlimb unloading in rats reduces baroreflex sensitivity and heart rate variability, but does not cause structural changes in carotid arteries.

Diffusion controls local versus dispersed inheritance of histones during replication and shapes epigenomic architecture

The paper develops a stochastic model of histone dynamics at the replication fork, showing that differential diffusivity explains histone inheritance patterns and predicts epigenomic patterns observed in experiments.

Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase Pathway

This study shows myoglobin promotes cardiomyocyte differentiation by modulating the Hippo pathway through oxidative regulation of LATS1 and YAP.

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

An investigation of the sex-specific genetic architecture of fitness in Drosophila melanogaster

The paper investigates sex-specific genetic effects on fitness in Drosophila melanogaster using three approaches across two mating environments, finding concordant genetic variation effects and stronger selection against certain mutations in females.

GTPase-dependent cyclic flexibility transitions drive the two-component EEA1-Rab5 molecular motor

This study shows that Rab5 and EEA1 form a two-component molecular motor using GTP hydrolysis to drive cyclic flexibility transitions that perform mechanical work.

Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

Selection for increased post-infection survival ameliorates mating induced immune suppression in Drosophila melanogaster females

This study shows that Drosophila melanogaster populations selected for increased post-infection survival show reduced mating-induced immune suppression compared to control populations.

Function and phylogeny support the independent evolution of acid-sensing ion channels in the Placozoa

This study identifies a proton-activated Deg/ENaC channel in Trichoplax adhaerens, showing it evolved independently from mammalian ASIC channels.

Correlated responses to experimental evolution of increased post-infection survival in Drosophila melanogaster: Life-history trade-offs and reaction to novel stressors

This study shows that Drosophila melanogaster can rapidly evolve increased resistance to E. faecalis infection without life-history costs or abiotic stress resistance.

Temperature Sensitive Contacts in Disordered Loops Tune Enzyme I Activity

This study identifies temperature-sensitive contacts in disordered loops of Enzyme I homologs that tune catalytic activity across temperatures.