L. Yu

An evolutionary epigenetic clock in plants

This paper introduces an epigenetic clock based on stochastic DNA methylation changes in plants, enabling high-resolution temporal analysis of phylogenetic relationships.

The biosynthesis, degradation, and function of cell wall β-xylosylated xyloglucan mirrors that of arabinoxyloglucan

The paper identifies enzymes involved in the biosynthesis and degradation of β-xylosylated xyloglucan and shows their potential role in gut bacterial nutrition.

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

Ocean currents drive the worldwide colonization of the most widespread marine plant, eelgrass (Zostera marina)

The paper reconstructs the colonization history of eelgrass using genomic data, showing trans-Pacific currents drove its spread and Atlantic populations arrived more recently with lower genetic diversity.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

The response mechanism of oreorchis patens (Lindl.) Lindl. to cold stress

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Tetraspanin 4 mediates migrasome formation via a two-stage mechanism

This study investigates how tetraspanin 4 mediates migrasome formation through a two-stage mechanism involving membrane tension and cholesterol.

Sustained ROS Scavenging and Pericellular Oxygenation by Lignin Composites Rescue HIF-1α and VEGF Levels to Improve Diabetic Wound Neovascularization and Healing

This paper develops lignosulfonate composites that enhance diabetic wound healing by promoting neovascularization and reducing ROS through sustained oxygen release and antioxidant properties.

Regulation of a single Inositol 1-Phosphate Synthase homeolog by HSFA6B contributes to fiber yield maintenance under drought conditions in upland cotton

The paper identifies a regulatory mechanism linking drought stress and fiber yield in upland cotton through the interaction of GhHSFA6B-D and GhIPS1-A, showing conservation in Arabidopsis.

Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature

This study shows that tetraspanin4 and CD9 sense positive membrane curvature, revealing their role in membrane shaping processes like migrasome formation and oocyte microvilli shaping.

IDPConformerGenerator: A Flexible Software Suite for Sampling Conformational Space of Disordered Protein States

IDPConformerGenerator generates diverse ensembles of disordered protein states using physical restraints and machine learning, enabling structural analysis of intrinsically disordered proteins.

Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Multifactorial remodeling of the cancer immunopeptidome by interferon gamma

This study identifies factors influencing immunopeptidome remodeling by IFN-gamma in colorectal cancer, revealing proline's role in peptide downregulation on HLA-I.

Quantitative prediction of ensemble dynamics, shapes and contact propensities of intrinsically disordered proteins

This study predicts the conformational dynamics, shapes, and contact propensities of intrinsically disordered proteins using advanced molecular dynamics simulations.

Modeling of Aryl Hydrocarbon Receptor Pathway Intrinsic Immunometabolic Role using Glioblastoma Stem Cells and Patient-Derived Organoids

This study identifies AHR's role in regulating intrinsic immunity, proliferation, and migration in GBM stem cells and organoids, linking it to poor prognosis and suggesting it as a therapeutic target.

Detecting clonemates in multicellular clonal species based on Shared Heterozygosity (SH) and technical replicates

The paper introduces a method to detect clonemates in multicellular clonal species using Shared Heterozygosity (SH) and technical replicates, showing its effectiveness in seagrass clones.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

Framework for Denoising Monte Carlo Photon Transport Simulations Using Deep Learning

This paper develops a deep learning framework to denoise Monte Carlo photon transport simulations, significantly improving image quality and reducing computational costs.

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.