M. Luo

Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

Natural variations in the P-type ATPase heavy metal transporter ZmCd1 controlling cadmium accumulation in maize grains

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

Identification of Lysine Isobutyrylation as A New Histone Modification Mark

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

The Evolution of Insect Metallothioneins

This study reconstructs the evolutionary history of insect metallothioneins by developing a BLAST pipeline and analyzing phylogenetics and synteny, revealing lineage-specific duplications and a previously unknown MT variant.

Alk1 mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

Genome-wide identification, characterization and expression analysis of the monovalent cation-proton antiporter superfamily, and their function analysis in maize salt tolerance.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

Interfering the mating of Chilo suppressalis (Walker): A new role of sex pheromones ((Z)-11-Octadecen-1-ol and (Z)-13 Octadecen-1-ol) from Cnaphalocrocis medinalis Guenee

The paper shows that sex pheromones from Cnaphalocrocis medinalis reduce the attraction of Chilo suppressalis males to their own pheromones, suggesting a potential method for pest control.

A novel vaccine targeting the viral protease cleavage sites protects Mauritian cynomolgus macaques against vaginal SIVmac251 infection

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

Individualized ctDNA Fingerprints to Monitor Treatment Response and Recurrence in Multiple Cancer Types

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

The role of two-component system response regulator BceR in antimicrobial resistance, virulence, biofilm formation, and stress response of group B Streptococcus.

This paper identifies BceR as a key regulator in Group B Streptococcus virulence, antimicrobial resistance, and stress response through functional analysis of a non-invasive strain.