statistical model

Superior Frontal Gyrus Cortical Thickness Mediates the Association Between Openness to Experience and Theory of Mind: Evidence from the Human Connectome Project

The ViRA-L (Visual Recognition Assessment-Leuven): Development, Validation, and Age Stratified Normative Characterization of a Multi-Category Visual Recognition Battery

The paper develops and validates the ViRA-L, a visual recognition battery with age-stratified norms, showing good reliability and age-related category-specific differences.

Structure constrained spin responses of an FMN superoxide radical-pair model in mitochondrial complex I

The paper examines how the geometry of the FMN pocket in mitochondrial complex I influences spin responses and singlet yields under varying conditions.

The human-specific gene FRMPD2B couples postnatal experience to the expansion of cortical connectivity

This paper identifies the human-specific gene FRMPD2B as an activity- and experience-regulated modifier of cortical connectivity, showing its role in postnatal brain development.

Enhancing Germination and Assessing the Longevity of Native Plants' Seeds with Dormancy through Different Priming Techniques

This study evaluates optimal seed-priming techniques for two native desert plants to enhance germination and assess seed longevity under artificial aging conditions.

Batch Effect Correction to Enhance Utility of a Publicly Available ALS Proteomics Dataset

The paper corrects batch effects in the Answer ALS proteomics dataset using BDCs and ComBat, improving data utility while preserving biological variability.

Twenty-five new microsporidian genomes: Insights into ploidy, reproduction, and the group's pangenome

The paper presents 25 new microsporidian genomes, revealing extreme pangenome diversity and novel tetraploid structures in some species.

Mapping bioimage-analysis software adoption in microscopy

The paper tracks the adoption of bioimage-analysis software across 1.7 million microscopy papers from 2010 to 2025, finding increased usage and concentration on general-purpose platforms like ImageJ/Fiji.

ScanFold3: a robust and rapid approach for identifying structured RNA targets in genomes and transcriptomes

ScanFold3 improves RNA structure prediction speed and accuracy, outperforming previous versions in benchmarking and validation.

Farm exposure is associated with human breast milk immune profile and microbiome

The paper compares immune profiles and microbiomes of breast milk from mothers with different farm exposures to identify associations with immune development and atopic disease.

Validating static food web model diet matrices using stable isotope simulation

This paper validates static food web diet matrices using stable isotope simulation to identify discrepancies and improve model accuracy.

Single-cell perturbation prediction near experimental reproducibility with GENESIS

GENESIS predicts single-cell perturbation responses from experimental conditions, outperforming existing models and approaching experimental reproducibility.

Developmental IL7/IL7R signaling in fetal resident tissue macrophages regulates adaptive responses to liver injury

This study shows that IL7/IL7R signaling during fetal development programs liver-resident macrophages, which are critical for postnatal immune responses to liver injury.

Rev-erb-alpha inhibits vascular calcification by repressing osteogenic reprogramming in atherosclerosis

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

How do the molecular determinants of antiviral resistance shape the dynamic of phytoplankton-virus interaction?

The paper models how antiviral resistance mechanisms in phytoplankton affect virus population dynamics, showing that bet-hedging strategies and intracellular resistance strongly reduce viral spread.

tWhEEL: a transcript-aware workflow for quantifying CRISPR knockout feasibility using transcriptome assembly

tWhEEL quantifies CRISPR knockout feasibility by integrating transcriptome data with guide RNA design and functional annotations to prioritize tractable biological functions and organisms.

Levodopa induced dyskinesia severity is linked to distinct microstructural alterations in nigrostriatal and brainwide neural circuits

This study investigates how L-DOPA-induced dyskinesia (LID) relates to microstructural changes in brain circuits, finding brainwide alterations beyond the nigrostriatal system.

Evasion of Hepatic ILC1 Immunosurveillance Drives Breast Cancer Liver Metastasis

This study identifies liver-resident ILC1s as a critical barrier against breast cancer liver metastasis, showing that DR5 expression and host metabolism influence this immunosurveillance.

Spatial and developmental reprogramming enables root growth under high salinity

This study identifies spatial developmental reprogramming in roots of Schrenkiella parvula under salinity, revealing distinct zones and regulatory programs that enable continued growth.

FiberBrowser: a unified framework for single-molecule genomics

FiberBrowser converts diverse single-molecule footprinting datasets into a unified representation for analyzing chromatin structure and function across assays.

Dairy cattle movement networks govern the spread and persistence of H5N1 B3.13 in the United States

The paper analyzes the spread of H5N1 B3.13 in U.S. dairy cattle using genomic data and movement networks, finding that cattle movement, not birds, drives the outbreak.

Ktd1 is a phospho-regulated member of the Dup240 family that mediates defence against killer toxin K28

This study identifies Ktd1 as a phospho-regulated member of the Dup240 family essential for defense against the K28 killer toxin in yeast.

Restoration decisions in highly variable systems: Whether, when, and how to enhance kelp

The paper evaluates kelp restoration strategies under environmental variability, finding grazing intensity and introduction life stages most influence outcomes.

Trisomy 21 Perturbs Oligodendrocyte Developmental States and Oligo-Neuron Communication in Human Forebrain Assembloids

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

Beyond Imbalance: An Elasticity Framework for the Distance-averaged Force-Velocity Relationship in Vertical Jump

This paper develops an elasticity framework to quantify how force-velocity relationship variables affect jump height and provides metrics for training prescription.

Siderophore-Mediated Competition Between Cystic Fibrosis Pathogens Increases Virulence Factor Production

This study shows Achromobacter spp. enhance Pseudomonas aeruginosa virulence by inducing siderophore production through iron competition in CF airways.

Linking the fundamental and realized niches in ahypersaline consumer-resource system

The paper investigates how salinity affects algal growth, grazer survival, and interaction strength in a hypersaline system, finding that ecological responses to salinity are evolvable and influence the relationship between fundamental and realized niches.

Integrative multi-omics re-analysis of public sequencing and metabolomics repositories defines the mucosal immune and metabolic landscape of Helicobacter pylori infection and supports CagW as a rational mRNA-LNP vaccine antigen

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

Kinetic gating by an iron sulfur chain modulates flavin radical-pair spin chemistry in mitochondrial Complex I

The paper models spin chemistry in mitochondrial Complex I's flavin radical pair, showing kinetic gating by iron sulfur clusters affects singlet yield and spin coherence.