cell-cell communication

MULTIVALENT ACE2 ENGAGEMENT ACTIVATES PIEZO1-SPHINGOMYELINASE SIGNALING IN SARS-COV-2 SPIKE-MEDIATED CELL-CELL FUSION

This study identifies a pathway by which SARS-CoV-2 Spike activates PIEZO1-sphingomyelinase signaling to promote cell-cell fusion through ceramide generation and phosphatase-mediated actin cortex detachment.

Human and Mouse Models of the Bipolar Disorder-Associated ANK3 p.W1989R Variant Display Altered Somatostatin Interneuron Connectivity and Function

This study investigates the effects of the ANK3 p.W1989R variant in human and mouse models, showing altered somatostatin interneuron connectivity and function linked to bipolar disorder.

Low-order MLKL oligomers induce irregular membrane defects in necroptosis

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

Directional information flow as a tool for analyzing protein allostery

The paper develops a method using transfer entropy to analyze directional information flow in proteins, identifying key residues involved in allosteric communication and demonstrating its utility in capturing dynamic changes.

SpacePath enables pathway and molecular-family analysis beyond annotation ambiguity in spatial metabolomics and lipidomics

SpacePath improves spatial metabolomics analysis by handling molecular ambiguity and identifying novel lipid families in spatial datasets.

MorphoDeep enables fast 3D cell instance segmentation by learning cell interfaces and junctions

MorphoDeep improves 3D cell segmentation by learning cell interfaces and junctions, achieving higher accuracy and speed than existing methods.

From Magnetosomes to Vesicles: LemA Proteins as Drivers of Bacterial Membrane Reorganization

This paper identifies LemA proteins as conserved drivers of bacterial membrane reorganization, involved in organelle and vesicle formation through interactions with divisome components and other membrane remodeling factors.

Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophages

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

Immune surveillance at plasmodesmata restricts the movement of a fungal effector

The paper identifies ChEC108 as a fungal effector that targets plasmodesmata in Arabidopsis, binds HIPP6, and induces plasmodesmal closure to restrict fungal spread.

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

Individual Differences in Sustained Attention Tune Semantic Abstraction in Neural Encoding of Narratives

The paper investigates how individual differences in sustained attention affect neural semantic encoding of narratives using fMRI and LLM embeddings, finding that attention shifts representations toward gist-level formats.

Gut microbial interaction networks control autoimmunity to neuroretina

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

Mitochondria-Targeted OGG1 remodels Alveolar Epithelial Transitional States and Immune-Epithelial Communication after Chlorine Lung Injury

This study uses single-nucleus RNA sequencing to identify epithelial transitional states and immune-epithelial communication changes after chlorine lung injury and shows mOGG1 remodels these states to promote recovery.

Sequential engagement of distinct dendritic cell subsets shapes Th2 polarization

The paper shows that distinct dendritic cell subsets sequentially engage CD4 T cells during priming, with late CD70 DC2s driving Th2 polarization.

Super-resolution mapping of platelet α-granules uncovers non-polarized secretion and differential retention of von Willebrand Factor and thrombospondin-1

This study uses super-resolution microscopy and computational analysis to show that platelet α-granules release cargo without polarity, with distinct retention mechanisms for TSP1 and VWF.

Snail restricts SARS-CoV-2 entry by limiting ACE2 expression as part of broader remodelling of epithelial determinants of viral tropism

This study identifies Snail as a host restriction factor that limits SARS-CoV-2 entry by reducing ACE2 expression through transcriptional regulation and translational suppression.

Cardiorespiratory fitness and sex impact the colorectal cancer-suppressive effects of aerobic exercise serum

This study shows that cardiorespiratory fitness and sex influence how exercise serum affects colorectal cancer cell viability.

Biome-specific genome catalogues reveal functional potential of shallow sequencing

The paper introduces BioSIFTR, a tool that uses shallow shotgun sequencing and biome-specific databases to generate accurate taxonomic and functional profiles, validated against deep sequencing data.

A computable probability landscape for T cell receptor repertoire sampling and comparison

The paper introduces BEAM, a probability model for TCRβ sequences that enables depth-aware sampling calculations and interpretable repertoire comparison.

Left Temporoparietal Neural Synchrony Tracks Cooperative Performance Across Adult Dyads

The paper examines neural synchrony in dyads during a cooperative task and finds it varies with relationship type and performance metrics.

Aurora kinase A enables collective invasion and metastasis by endowing a leader cell phenotype and stabilizing cohesion with follower cells

This study identifies Aurora kinase A's role in promoting collective cell invasion and metastasis by enabling leader cell phenotypes and stabilizing cohesion with follower cells.

Circular DNA interacts with Cathelicidin LL37 to efficiently activate plasmacytoid dendritic cells

The paper shows circular DNA activates plasmacytoid dendritic cells, and LL37 enhances this activation through TLR9, highlighting DNA topology's role in immune sensing.

The Role of Environmental Information and the Limitations of Predictability with Transformer-based Time-Series Models for complex Astrocyte Trajectories

This study uses a Transformer-based model to predict astrocyte migration during mouse brain development, finding that environmental information and multimodal modeling improve prediction accuracy.

Temporal Dynamics of SMARCA4 Loss Define Its Role in Myogenic Differentiation of Alveolar Rhabdomyosarcoma

This study shows that acute SMARCA4 loss in ARMS cells does not induce differentiation or alter proliferation, contrasting with long-term knockdown effects.

An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer's disease pathology

Odad1 is Required for Deployment of Axonemal Outer Arm Dyneins and Embryonic Left-Right Patterning

This study shows ODAD1 is essential for ODA-DC assembly in 9+0 and 9+2 cilia, causing left-right patterning and ciliary motility defects in ciliopathy.

Abnormal nuclear organization impairs adipogenic lineage commitment and terminal maturation in Hutchinson-Gilford progeria syndrome (HGPS)

This study shows that HGPS disrupts adipogenic lineage maturation through chromatin reorganization defects, despite normal lineage commitment rates.

geoGraph: Connectivity modelling across geographic space with hexagonal discrete global grids

geoGraph models organism movement and connectivity across geographic space using hexagonal grids, improving accuracy over rectangular grids by avoiding distortion.

Epithelial function of the circadian clock gene, Bmal1, in regulating the mucosa.

This study shows that Bmal1 in colon epithelial cells promotes mucus production and is essential for sex-specific tissue regeneration after injury.

Single-cell characterization of the human immune landscape reveals dysfunction in monocyte-mediated cellular interactions in symptomatic malaria

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.