cell-cell communication

EV-Tracer enables lineage-resolved detection and molecular profiling of extracellular vesicle-associated signals in cancer-fibroblast co-culture

EV-Tracer detects and profiles lineage-specific extracellular vesicles in cancer-fibroblast co-cultures, revealing interferon-related RNA signatures associated with cell-cell contact.

Aquaporin-4 Regulates Edema, Sustains Astrocyte Differentiation, and Constrains Immunosuppressive Remodeling in Glioblastoma

This study shows that AQP4 regulates edema, maintains astrocyte differentiation, and limits immunosuppressive changes in glioblastoma.

PACAP engages distinct signaling programs across cortical neuronal and non-neuronal cell types

The paper investigates how PACAP signaling varies across cell types in the temporal association cortex during fear learning and memory.

Specialized and experience-dependent neural dynamics in the medial amygdala and bed nucleus of stria terminalis upon social and sexual olfactory and tactile cues

This study examines neural activity in the medial amygdala and bed nucleus of the stria terminalis in male rats during social and sexual interactions, revealing distinct response patterns to olfactory and tactile cues based on experience.

Rapid thermoforming of polycarbonate cell culture accessories from 3D printed molds

This paper introduces a method to rapidly create customized, autoclavable cell culture accessories using polycarbonate thermoforming from 3D printed molds, demonstrating compatibility with human iPSC culture and differentiation.

Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

Effector-primed TCF1+ CD8+ T cells elicited by a networked epitope vaccine stratify protection against SHIV acquisition

This study identifies an effector-primed TCF1+ CD8+ T cell state linked to delayed SHIV acquisition and reduced viral load in vaccinated non-human primates.

Mechanical history shapes phenotypic plasticity and fibroblast-autonomous 3D remodeling in iPSC-derived cardiac fibroblasts

This study shows that mechanical culture history affects iPSC-derived cardiac fibroblasts' phenotype and TGF-beta1 response, but later passages can alter these effects.

Oncogenic KRAS-MAPK signaling sustains a CD73 dependent therapeutic vulnerability in pancreatic cancer

This study shows that combining CD73 and RAS(ON) inhibition reduces tumor growth and immune suppression in pancreatic cancer by targeting KRAS-MAPK driven CD73 signaling.

Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart

The paper constructs a multi-scale atlas of cardiomyocyte changes in infarcted hearts, showing partial identity loss without regenerative proliferation and altered intercellular communication.

Host brain infection induces RNAi epimutation in Mucor circinelloides and enhances blood-brain barrier invasion

The paper shows brain infection induces RNAi epimutations in Mucor circinelloides that enhance blood-brain barrier invasion.

Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-α

This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.

Cone outer segment renewal in vivo involves progressive particle formation at the photoreceptor-RPE interface

This study uses live imaging in zebrafish to show that cone outer segments are removed in small, successive particles at the cone-RPE interface without extracellular accumulation.

Building Bridges Belowground: Pythium oligandrum En-hances Rhizosphere Network Connectivity

This study shows that Pythium oligandrum modifies microbial interactions in the potato rhizosphere without changing overall bacterial community composition, affecting network connectivity.

The Endoplasmic Reticulum as a Cytoplasmic Anchor for Microtubule-Driven Aster Centration

The paper investigates how the endoplasmic reticulum (ER) contributes to microtubule aster centration in sea urchin zygotes through mechanical interactions and 3D modeling.

Calcium signaling recruits Rab27a and the exocyst complex to promote small extracellular vesicle release in skeletal muscle cells

Spatial uncoupling of endothelial calcium signaling from phosphatidylserine externalization in vascular injury

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

Transient cortical activity modulates somatosensory gating during postural control

This study shows that somatosensory responses during postural control are influenced by prestimulus cortical activity and connectivity, with specific beta-band features correlating with changes in evoked potentials.

A knowledge graph-guided framework for multitask single-cell analysis

scKNIFE integrates gene expression with functional annotations to identify tumor programs and treatment-related functional variation in breast cancer.

Longitudinal fMRI reveals altered developmental trajectories of functional network organisation associated with adolescent cannabis use

This study uses longitudinal fMRI to show that adolescent cannabis use is associated with distinct changes in functional network organisation compared to adults.

Artificial hibernation uncovers distinct interaction dynamics in functional and pathological state change

This study uses artificial hibernation to show that neural network reorganization can occur without functional impairment and may prevent pathological state progression.

SHROOM3 promotes leading-edge protrusion stability and Wnt/planar cell polarity-mediated migration in breast cancer cells

This study identifies SHROOM3 as a regulator of protrusion dynamics and Wnt/PCP-mediated migration in breast cancer cells, showing its role in stabilizing protrusions and coordinating ROCK1 localization.

Brain microvascular endothelial cell dysfunction during Plasmodium infection does not result from astrocyte-derived wingless-related integration site (Wnt)7a deficiency

This study investigates whether astrocyte-derived Wnt7a deficiency contributes to BMEC dysfunction during Plasmodium infection, finding no protective effect of Wnt7a overexpression on cerebral malaria outcomes.

Signal Associa: hot tumors elicit field-spanning NK cell coordination linked to their recruitment

Signal Associa identifies coupling regimes in NK cell dynamics across tumor microenvironments, showing hot tumors elicit more integrated NK cell networks.

Coordination of cell cycle and hematopoietic differentiation by a HoxA9/Myc/Cdk6 feedback loop

This study identifies a HoxA9/Myc/Cdk6 feedback loop that coordinates cell cycle and hematopoietic differentiation through transcriptional and post-translational mechanisms.

ANO6 Scaffolds ER Mitochondria Contacts to Govern Spatial Lipid Compartmentalization and Ferroptosis Evasion in Chemoresistant Breast Cancer

This study identifies ANO6 as a scaffold at ER-mitochondria contacts that facilitates lipid sequestration and ferroptosis evasion in chemoresistant breast cancer.

Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation

This study creates mesaconate-based polyester nanoparticles that show different immunomodulatory effects in macrophages and improve survival in endotoxemia.

Disease-associated MYH11 tail variants disrupt vascular smooth muscle myosin II filament dynamics and cell mechanics

This study examines how disease-associated MYH11 variants affect SMII filament dynamics and VSMC mechanics through live-cell imaging, revealing distinct functional impacts of K1256del and A1839V variants.

Novel 3D Mature Osteocyte Perfusion Platform Reveals Subtype-Dependent and Radiation-Sensitive Disruption of Mechanotransduction by Breast Cancer Secretomes

This study shows that breast cancer subtype and radiation affect osteocyte mechanosensing, with ER+ tumors being more sensitive to radiation-induced secretome changes.

A non-invasive approach to study localized forced in 3D epithelia

This paper introduces a non-invasive method to study localized mechanical forces in 3D epithelial tissues using elastic microbeads and shows how cytoskeletal remodeling and adhesion organization respond to mechanical perturbations.