T-cell and B-cell Immunology

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.

This study shows that IL-1R2 on Tfr cells prevents excessive activation and allergy by limiting IgE and promoting IgG responses.

This study shows CD6 suppresses CD4 T cell activation and follicular helper cell differentiation during viral infection, reducing antiviral humoral immunity.

The paper develops a method to select optimal TCR transgenic clones using single-cell RNA sequencing and TCR repertoire analysis, enabling the generation of CORSET8 mice specific to SARS-CoV-2 Spike protein.

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

Congenital T cell activation in CTLA4-deficient patients impairs transitional to follicular B cell maturation and can be rescued by CTLA4 replacement therapy in vivo.

This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.

The paper shows that delaying Bcl11b activation via an epigenetic switch increases ILC generation and reduces T cell output in the thymus by redirecting progenitors at the T/ILC branchpoint.

This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

This study uses single-cell RNA-sequencing and V(D)J repertoire analysis to characterize feline immune cell subsets and compare them across species.

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

This study shows that beta-adrenergic signaling and T-lymphocyte-produced catecholamines are required for IL-17A synthesis, offering new therapeutic targets for PTSD and autoimmune diseases.

This study improves T cell-antigen specificity prediction by integrating kinetic data into affinity-driven models, enhancing predictions for low-affinity TCR-pMHC interactions.

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.

The paper shows an IL-2 mutein expands regulatory T cells that enhance IL-10 and CTLA-4 to suppress dendritic cells, reducing autoimmunity in NOD mice.

This study shows high intracellular calcium inhibits T cell proliferation in vitro and reduces colitis in vivo, suggesting calcium modulation could treat autoimmune diseases.

This study shows that B cell c-Maf signaling promotes tumor progression in pancreatic cancer and melanoma by modulating Breg, inflammatory responses, and tumor-specific antibody production.

This paper develops a 45-color flow cytometry panel for high-resolution immunophenotyping of human peripheral blood mononuclear cells, with a focus on T cell memory subsets, demonstrating improved resolution and functional characterization.

This study shows that inhibiting S1P signaling with FTY720 suppresses Th1-like Treg generation and restores their suppressive function by reversing mitochondrial uncoupling.

This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.

The paper identifies gene regulatory modules in thymic regulatory T cells to prioritize variants in complex diseases and uncover mutational hotspots.

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

This study shows that CXXC1 interacts with FOXP3 to regulate Treg cell function and epigenetic stability, essential for immune homeostasis and preventing inflammation.

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.

This paper introduces a modified Fab'-DNA ligand to study TCR signal integration by controlling kinetic on- and off-rates, revealing how dwell time affects TCR signaling and LAT condensation.

The paper identifies age-associated TCR repertoire components using a new computational framework and links them to immune aging and clinical outcomes.