Nanoparticle-Based Drug Delivery

Modular in vitro evaluation of Buparlisib-polymeric nanomedicines in 2D and 3D models of glioblastoma

This study evaluates Buparlisib-polymeric nanomedicines in 2D and 3D glioblastoma models, finding that redox-sensitive conjugates show better activity than azide-based ones.

A Protease-Cleavable iNOS-Inhibitor Polymeric Prodrug Designed for Controlled Modulation of Nitric Oxide

This paper develops a protease-cleavable iNOS-inhibitor polymeric prodrug (ProCIP) that enables localized iNOS inhibition and NO regulation in inflammatory disorders and tumors.

Biodegradable Nanoparticle-in-Implant Platform for Sustained and Light-Boosted Pirfenidone Delivery

This paper develops a biodegradable nanoparticle-in-implant platform for sustained and light-boosted pirfenidone delivery to treat vocal fold fibrosis.

Intra-nanoparticle Drug-protein Interactions Mediate Sequential Therapeutic Release

This study develops a drug delivery system using HSA nanoparticles where vancomycin modulates drug release kinetics through interactions with albumin's secondary structure.

Hydroxy polyethylene glycol: a solution to evade human pre-existing anti-PEG antibodies for efficient delivery

This study shows that hydroxy PEG (OH-PEG) reduces binding to pre-existing anti-PEG antibodies, improving stability and reducing immunogenicity of PEGylated nanomedicines.

Nature-Inspired Nanoparticle Adiposomes Enable Targeted Delivery of Hydrophobic Drug for Anti-Cancer Treatment

This paper develops adiposomes, a biocompatible nanoparticle platform for hydrophobic drug delivery, showing improved efficacy and reduced toxicity in cancer models.

In Vitro Efficacy of Paclitaxel-loaded PLGA Nanoformulations for Lung Cancer Treatment Demonstrated by Label-free Multiphoton-Fluorescence Lifetime Imaging Microscopy

This study evaluates paclitaxel-loaded PLGA nanoparticles for lung cancer treatment, showing enhanced efficacy and using label-free multiphoton imaging to track metabolic changes.

Controlled delivery of iNOS antagonist, 1400W, for synergistic breast cancer therapy

This study develops pH-responsive nanoparticles to deliver 1400W, an iNOS inhibitor, which synergizes with paclitaxel to enhance anti-tumor effects in TNBC cells.

High Drug-Loading Rucaparib-FdUMP Nanocarriers for Colorectal Cancer Combination Therapy

This paper develops high drug-loading nanocarriers for co-delivering rucaparib and FdUMP in colorectal cancer, showing synergistic cytotoxicity and DNA damage.

High-Sensitivity Magnetic Levitation Reveals Intrinsic Protein Corona Heterogeneity on Identical Nanoparticles

This paper introduces a high-sensitivity magnetic levitation method to detect protein corona heterogeneity on identical nanoparticles, revealing hidden compositional differences not captured by conventional pooled analysis.

Synthesis and Characterisation of a Macrophage-derived Hybrid Nanoparticles for Doxorubicin Delivery to Glioblastoma

This study develops hybrid nanoparticles combining liposomes and macrophage-derived extracellular vesicles for targeted doxorubicin delivery to glioblastoma, showing improved encapsulation efficiency and pH-sensitive release.

Targeting intracellular mycobacteria using novel antibiotic-loaded nanoparticles

This paper develops mannose-functionalized nanoparticles loaded with rifampicin to target macrophage-associated mycobacteria, showing improved efficacy and reduced toxicity in preclinical models.

Sustainable Technology for the Fabrication of Liposomal Phases

This study develops a sustainable method for creating liposomal lamellar phases through optimized hydration and sonication, along with a machine-learning tool for vesicle size analysis.

Amphiphilic Peptide Fusion Promotes Endocytic Uptake of Nanodiscs

This study shows that fusing an amphipathic peptide to nanodiscs enhances endocytic uptake and reduces endosomal sequestration, improving drug delivery efficiency.

Development of approaches to overcome the drop in hematocrit when implementing mononuclear phagocyte system cytoblockade in vivo used to prolong the circulation of nanoparticles in the blood

The paper demonstrates methods to restore hematocrit during MPS-cytoblockade, preserving nanoparticle circulation and tumor targeting without compromising safety.

When lysosomes persist: resolving the proton-sponge paradox in nanoparticle-based intracellular delivery

This study investigates how proton-sponge polymers like PEI enable cargo release without full nanoparticle escape, resolving a long-standing debate in nanomedicine.

Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates Nanotherapeutics

This paper designs a new class of antibody-drug conjugates by leveraging drug hydrophobicity to create self-assembling nanotherapeutics with improved therapeutic properties.

The delivery of nano-formulated drugs to solid tumours is selectively increased by co-application of the vascular disrupting agent CA4P

This paper shows that co-administering vascular disrupting agents with nanoparticle drugs increases tumoral uptake without increasing systemic exposure.

Ultra-long stable biomimetic nanoparticle Click-ed-to-cancer membrane for anti-cancer treatment

The paper develops a stable biomimetic nanoparticle using click-chemistry to coat cancer cell membranes for anti-cancer treatment.

Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route

This study develops a nanoparticle system to deliver Panobinostat intrathecally for treating metastatic medulloblastoma, showing improved drug distribution and survival benefits in mice.

Precision control of nanoparticle delivery with engineered biomimetic protein coronas

This paper engineers biomimetic protein coronas on nanoparticles to improve tumor targeting and reduce immune recognition, achieving 4% ID/g tumor accumulation.

Fibrinogen-Drug Nanoparticles Eradicate Pancreatic and Triple-Negative Breast Cancers in Mice

This paper develops fibrinogen-drug nanoparticles that deliver sustained chemotherapy to tumors, effectively eradicating advanced breast and pancreatic cancers in mice.

Process for Standardizing and Assessing the Parameters Governing MS2 Virus-Like Particle Reassembly around Nucleic Acid Cargo

This paper introduces a standardized framework to quantify MS2 VLP reassembly yields and identifies key parameters affecting reassembly efficiency.

Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery

This paper develops ApoE-functionalized fusogenic liposomes to deliver resveratrol to the brain, improving vascular function and cognitive performance in aged mice with reduced drug dosage.

ENHANCING TUMOR PERFUSION AND NANOMEDICINE DELIVERY VIA ENDOGENOUS NITRIC OXIDE RELEASE BY METHYL PALMITATE NANOPARTICLES

This study shows that methyl palmitate nanoparticles enhance tumor perfusion and nanomedicine delivery by inducing vasodilation and reducing phagocytosis.

Surface Functionalized RBC Membrane-Derived Nanoparticles for Targeted Drug Delivery to Attenuate Fatty Liver Disease

This study develops hepatocyte-targeting cell membrane-derived nanoparticles loaded with resmetirom to treat MASLD, showing improved bioactivity in vitro.

Overcoming Cisplatin Resistance in 3D Oral Squamous Cell Carcinoma Models via Nanoparticle-Mediated Pt(IV) Drug Delivery.

This study evaluates Pt(IV)-based prodrug delivery via mesoporous silica nanoparticles in 3D oral squamous cell carcinoma models, showing improved cytotoxicity and apoptotic effects compared to cisplatin.

Endocytosis of PEGylated polymeric mesoscale nanoparticles is dynamin- and macropinocytosis-dependent

This study investigates the stability and endocytosis mechanisms of PEGylated polymeric mesoscale nanoparticles, finding they are dynamin- and macropinocytosis-dependent.

Detailed splenic single-cell biodistribution of phosphatidylglycerol-containing liposomes

This study compares the biodistribution of rigid and flexible liposomes in the spleen and identifies APC subsets involved in immune tolerance.

Isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential

This study isolates and characterizes nanovesicles from Bacopa monnieri, showing their anti-neuroblastoma activity and bioactive properties.