Cervical Cancer and HPV Research

Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

This study examines how HPV integration affects host chromatin structure and gene regulation in cervical cancer, finding that integrations are enriched in active chromatin regions and induce local and long-range transcriptional upregulation within TADs.

Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single-cell transcriptomic analysis

Integrative Multi-Omics Approaches for Identifying Cervical Cancer Therapeutic Targets

This paper explores integrative multi-omics approaches to identify therapeutic targets for cervical cancer by analyzing HT data and clinical information.

Interaction with TopBP1 mediates human papillomavirus 16 E2 plasmid segregation/retention function and stability during the viral life cycle

This study shows that HPV16 E2 protein interacts with TopBP1 to mediate plasmid segregation and stability during the viral life cycle, and that this interaction is essential for E2 expression and function.

Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers

This study identifies HPV integration hotspots in oropharyngeal cancers and shows their role in disrupting host gene expression and genomic stability.

A critical role for E2-p53 interaction during the human papillomavirus 16 life cycle

This study shows that the E2-p53 interaction is critical for HPV16 life cycle, with disruption leading to anti-viral effects like reduced proliferation and increased DNA damage.

Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

The paper analyzes the genetic diversity of HPV types 16, 18, 52, and 58 in southern China, identifying sublineages and mutations associated with oncogenic potential.

The Mus musculus papillomavirus type 1 E7 protein binds to the retinoblastoma tumor suppressor - implications for viral pathogenesis

This paper shows that the MmuPV1 E7 protein binds RB1 without using the canonical LXCXE motif and that this interaction is essential for papilloma formation in mice.

APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma

This study shows that APOBEC mutagenesis occurs in both tumor and viral genomes in HPV+ OPSCC, suggesting a direct link between viral restriction and host mutations.

Inferring viral occurrence patterns through a synthetic data simulation

The paper demonstrates using network modeling to simulate synthetic viral datasets for estimating pathogen occurrence and interaction patterns.

Analysis of the association between TLR2 rs111200466 variants and cervical Cancer susceptibility in Sudanese women

This study examines the association between TLR2 -196 to -174del polymorphism and cervical cancer risk in Sudanese women, finding no significant association.

Mutation Profiles, Glycosylation Site Distribution and Codon Usage Bias of HPV16

The paper analyzes mutation profiles, glycosylation sites, and codon usage bias in HPV16 genomes to understand lineage differences and adaptation mechanisms.

HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples

The paper analyzes APOBEC3-induced mutations and integration patterns in HPV16 and HPV18 cervical samples across different disease stages to identify genomic factors associated with cancer progression.

SearcHPV: a novel approach to identify and assemble human papillomavirus-host genomic integration events in cancer

SearcHPV identifies and assembles HPV-host integration sites in cancer with higher sensitivity and specificity than existing methods.

GWAS meta-analysis and gene expression data link reproductive tract development, immune response and cellular proliferation/apoptosis with cervical cancer and clarify overlap with other cervical phenotypes

The paper performs a GWAS meta-analysis of cervical cancer and links it to reproductive tract development, immune response, and cellular proliferation/apoptosis, while also identifying genetic risk factors for other cervical phenotypes.

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function

This paper shows that CK2 phosphorylation of HPV16 E2 on serine 23 promotes interaction with TopBP1, which is critical for plasmid retention and HPV16 immortalization of keratinocytes.

A Systems Approach Identifies Key Regulators of HPV-Positive Cervical Cancer

This study identifies key regulatory pathways and proteins in HPV-positive cervical cancer through systems-level analysis, suggesting potential drug targets.

Virus-host protein-protein interactions between human papillomavirus 16 E6 A1 and D2/D3 sub-lineages: variances and similarities

The paper identifies virus-host protein-protein interactions between HPV16 E6 variants and host proteins, revealing differences in their carcinogenic potential through PPI analysis.

Werner syndrome protein (WRN) regulates cell proliferation and the human papillomavirus 16 life cycle during epithelial differentiation

This study shows WRN regulates cell proliferation and HPV16 life cycle in epithelial differentiation by controlling DNA replication and DNA damage.

Novel microRNA multivariate biomarkers of response to immunotherapy against HPV E6 oncogene

The paper identifies miR signatures modulated by anti-HPV E6 mAbs that predict response to treatment in cervical cancer models.

Diagnostic value of circulating tumor DNA as an effective biomarker in cervical cancer: a meta-analysis

This study evaluates ctDNA as a biomarker for cervical cancer through a meta-analysis, finding high specificity and moderate sensitivity.

Human papillomavirus 16 E6 and E7 synergistically repress innate immune gene transcription

This study shows that HPV16 E6 and E7 proteins synergistically repress innate immune gene expression in the context of the full HPV16 genome, with neither protein alone sufficient for repression.

Human papillomavirus 16 E2 regulates keratinocyte gene expression relevant to cancer and the viral life cycle

This study shows HPV16 E2 regulates host gene expression in keratinocytes, overlaps with genome-wide effects of HPV16, and correlates with clinical outcomes in head and neck cancers.

Development and Validation of a Method for Human Papillomavirus Genotyping Based on Molecular Beacon Probes

This paper develops and validates a new HPV genotyping method using molecular beacon probes and linear-after-the-exponential-PCR, showing high sensitivity, specificity, and agreement with existing tests.

Impact of specimen age on its DNA quality for Formalin-Fixed Paraffin-Embedded HPV specimens

This study examines how specimen age affects DNA quality in FFPE HPV specimens, finding that older specimens show degraded DNA quality and reduced HPV type detection.

The Effect of Productive HPV16 Infection on Global Gene Expression of Cervical Epithelium

This study identifies global gene expression changes in early-stage HPV16 infection in cervical tissue, revealing distinct transcriptomes compared to cancerous stages and potential therapeutic targets.

Identification of biomarker and HPV strain for Cervical Cancer from pre-existing RNAseq data

The paper assesses HPViewer's performance on RNA-seq data for HPV strain detection and evaluates p16INK4a as a biomarker for cervical cancer using RNA-seq data from multiple sources.

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

The paper validates a low-cost HPV testing method and finds 13% HPV prevalence in cancer-free women in Guatemala, with HPV16 being the most common type.