Cervical Cancer and HPV Research

Chromatin assembly by the histone chaperone HIRA facilitates Human Papillomavirus replication

This study shows that the histone chaperone HIRA and its complex are recruited to HPV replication factories, facilitating viral DNA amplification and transcription.

A Cross-Sectional Study on the Current Status and Determinants of Human Papillomavirus Infection in Women from Suzhou, China

This study examines HPV infection rates and risk factors in Suzhou women, finding high prevalence and identifying key risk factors for targeted prevention.

Scalable long-read Nanopore HPV16 Amplicon-based Whole-Genome Sequencing

This paper develops a scalable long-read sequencing method for HPV16 genome analysis, showing high accuracy and capturing full genetic diversity across multiple lineages.

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell line

The paper uses genomic tools to analyze HPV-human DNA integration structures in a cancer cell line, revealing complex intrachromosomal and extrachromosomal architectures.

In situ cryo-ET redefines HPV disassembly and transport paradigms

This study uses in situ cryo-ET to show HPV remains intact during retrograde transport and lysosome residency, challenging existing models of viral disassembly and transport.

Exploring human papilloma virus-induced cytological and molecular alterations: a hybrid study on inflammatory pathways and therapeutic strategies

This study investigates HPV-induced inflammation and cellular changes in cervical cancer, finding strong associations between high-risk HPV genotypes and severe inflammatory responses, particularly in younger individuals.

Assessing Knowledge, Uptake and Factors associated with cervical cancer screening among women in selected communities of Wakiso District in Uganda: A population-based study

This study assesses cervical cancer screening knowledge and uptake among Ugandan women, finding high knowledge but low uptake, with urban residence, age, partner involvement, and HIV status associated with higher uptake.

Human Papillomavirus Genomes Associate with Active Host Chromatin during Persistent Viral Infection

This study shows HPV31 genomes associate with active host chromatin regions, linking viral persistence to transcriptional activity and integration sites in cervical cancers.

Covalent Inhibition of the Human Papillomavirus Type 16 E6 Protein Restores p53 and Suppresses HPV-Driven Tumorigenesis

The paper develops covalent inhibitors targeting HPV16 E6 protein, restoring p53 function and suppressing HPV-driven tumorigenesis in vitro and in vivo.

Super-pangenome analysis of 3562 human and animal papillomavirus isolates illuminates their genome and pathogenicity evolution

The paper analyzes 3562 human and animal papillomavirus genomes to uncover genomic diversity, evolutionary patterns, and pathogenicity drivers, identifying key mutations and variants associated with cancer risk and prognosis.

Tracking Replicating HPV Genomes in Proliferating Keratinocytes

This paper uses ANCHOR technology to track HPV18 genomes in live keratinocytes, showing they are randomly partitioned to daughter cells during division.

An organotypic in vitro model of human papillomavirus-associated precancerous lesions allowing automated cell quantification for preclinical drug testing

This paper develops an organotypic in vitro model of HPV-induced precancerous lesions and uses machine learning to automate cell quantification for drug testing.

Monitoring Circulating Cell-free HPV DNA in Metastatic and Recurrent Cervical Cancer: Clinical Importance and Implications for Treatment - A Pilot Study

This study monitors HPV cfDNA levels in patients with recurrent or metastatic cervical cancer to assess its utility as a tumor marker for disease surveillance and treatment guidance.

A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade

The paper investigates early HPV infection steps by showing virions transfer from the ECM to CD151 via active recruitment, a process distinct from passive diffusion in cell culture.

The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle.

This study shows that SRPK1 inhibition with SRPIN340 blocks HPV16 late gene expression and restores epithelial barrier and immune function by affecting splicing and gene expression.

WAVE1 and WAVE2 facilitate human papillomavirus-driven actin polymerization during cellular entry

This study identifies WAVE1 and WAVE2 as mediators of actin polymerization required for HPV16 entry into epithelial cells through filopodia formation.

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

The paper uses long-read sequencing to analyze HPV integration sites in cervical cancer genomes, identifying structural and epigenetic impacts of integration.

HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes

This study characterizes 70 HPV16-specific monoclonal antibodies, identifying common neutralization loops and shared developmental pathways among vaccine-induced antibodies.

KAT8 facilitates the proliferation of cancer cells through enhancing E7 function in HPV-associated cervical cancer

This study shows KAT8 enhances E7 function in HPV-associated cervical cancer by promoting its acetylation and interaction with pRb/E2F1, leading to cell proliferation.

Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions

This study shows that HPV18 infection reprograms host transcription by altering CTCF binding and promoter-enhancer interactions, leading to repression of the tumor suppressor CADM1.

Analysis of the progression of cervical cancer in Guatemala- from pre-malignancy to invasive disease

This study analyzes RNA from cervical biopsies to identify gene expression changes and survival associations during cervical cancer progression in Guatemala.

Fibroblasts Regulate the Transformation Potential of Human Papillomavirus-positive Keratinocytes

This study shows fibroblasts support HPV RNA expression and episomal maintenance but reduce EMT-related expression in HPV+ keratinocytes.

Genome Instability Precedes Viral Integration in Human Papilloma Virus Transformed Tonsillar Keratinocytes

This study shows that genomic instability occurs before viral integration in HPV-transformed cells and that episomal virus leads to less tumorigenicity than integrated virus.

Novel nanopore sequencing method for determining Human Papillomavirus integrations in tumors without the need for whole genome sequencing

The paper develops a nanopore sequencing method to identify HPV integrations in tumors without whole genome sequencing, validated in cell lines and cervical cancer patients.

PRMT1 Modulates Alternative Splicing to Enhance HPV18 mRNA Stability and Promote the Establishment of Infection

This study identifies PRMT1 as a critical factor in HPV18 infection by modulating alternative splicing and mRNA stability, promoting persistent infection in primary human cervical cells.

Invasive cancer and spontaneous regression two weeks after papillomavirus infection

This study shows that invasive cancer can develop and regress within weeks after papillomavirus infection in mice, highlighting the rapid progression and immune dependence of tumor regression.

APV9WR: An Integrated Web Resource of Alpha papillomavirus 9 for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis

The paper develops APV9WR, a web resource for analyzing Alpha papillomavirus 9 genomics, proteomics, phylogenetics, and therapeutics using bioinformatics tools and datasets from GenBank and NCBI Virus.

Virus-host interaction: investigating novel transcription factors involved in coupling HPV life cycle and epithelial differentiation.

The paper identifies host transcription factors involved in HPV-18 life cycle regulation during epithelial differentiation and shows their impact on viral transcription and carcinogenesis.

A Peptide Derived from Sorting Nexin 1 Inhibits HPV16 Entry, Retrograde Trafficking, and L2 Membrane Spanning

This study shows that the peptide SNX1.3 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning, without affecting cell proliferation or post-Golgi trafficking.

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels

This paper identifies a mitotic E2-TopBP1 complex that inactivates SIRT1, promoting E2 acetylation and stability through p300, which protects against ubiquitination and proteasomal degradation.