Nitric Oxide and Endothelin Effects

Hepatic Xanthine Oxidoreductase Sustains Antithrombotic Nitric Oxide Signalling Through the Nitrate-Nitrite-Nitric Oxide Pathway

This study shows that hepatic xanthine oxidoreductase (XOR) sustains antithrombotic nitric oxide signaling through the nitrate-nitrite-NO pathway, and dietary nitrate can restore this signaling when endothelial NO is deficient.

Lysine methyltransferase SET7 links cardiometabolic risk to endothelial dysfunction by dysregulating mRNA splicing and eNOS-CaM interaction

This study identifies SET7 as a driver of endothelial dysfunction in cardiometabolic disorders by altering mRNA splicing and eNOS-CaM interaction.

CCR5/CCL5 Links Mitochondrial Dysfunction to Angiotensin II Vascular Injury

This study shows that Ang II enhances CCL5/CCR5 signaling, leading to mitochondrial dysfunction and oxidative stress in vascular smooth muscle cells, contributing to vascular injury in hypertension.

Endothelium-Dependent Vasodilation is Impaired in Chronic Spinal Cord Injury and is Associated with Oxidative Stress

This study shows that chronic spinal cord injury impairs endothelium-dependent vasodilation and links this dysfunction to oxidative stress.

Structural Basis of Electron Transfer by the Human Nitric Oxide Synthase Holoenzyme Complex

This study reveals the structural basis of electron transfer in the human inducible NOS holoenzyme complex using cryo-EM, showing how cofactors are arranged for catalysis.

L-Arginine supplementation modulates L-Arg/NO metabolic processes and AMPK/ACC-1 signalling in BNL CL2 hepatocytes

This study examines how L-arginine affects NO and AMPK/ACC-1 signaling in liver cells, showing changes in gene expression and cell growth with varying L-arginine concentrations.

Smooth muscle LRRC8A knockout reduces superoxide influx, inflammation, senescence and atherosclerosis

This study shows that knocking out LRRC8A in vascular smooth muscle cells reduces superoxide influx, inflammation, senescence, and atherosclerosis.

High-Fat Diet-Induced Obesity Impairs Endothelium-Dependent Relaxation via MLCK Activation: Reversal by ML-7 in Rabbits

Endothelial Nucleoporin93 (Nup93) Maintains Vascular Function via Sun1-Dependent Regulation of RhoA-eNOS Signaling

This study shows that endothelial Nup93 stabilizes Sun1, which regulates RhoA-eNOS signaling, maintaining vascular function and NO bioavailability.

Hepatic ADMA/PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASH

This study investigates how MASH impairs endothelial function via NO-dependent mechanisms and identifies ADMA as a key liver-derived mediator.

Sialin2 Senses Nitrate to Activate Endosomal PI3K-AKT-NOS Signaling

This study identifies Sialin2 as a mammalian nitrate sensor that activates endosomal PI3K-AKT-NOS signaling to enhance angiogenesis and cell survival, offering new therapeutic strategies for vascular disorders.

Heme-NO dilates arteries via mobilization of NO moieties from a vascular intracellular NO store

The paper investigates how heme-NO signals as a nitrodilator to vasodilate by mobilizing NO moieties from an intracellular NO store, showing its role in vascular function.

Klebsiella pneumoniae disrupts vasodilation by targeting eNOS post translational modifications via the type VI secretion system and the capsule polysaccharide

This study shows Klebsiella pneumoniae inhibits vasodilation by targeting eNOS post-translational modifications through its T6SS and capsule polysaccharide.

Distinct effects of acute and chronic blood loss anemia on vascular function after acute myocardial infarction

This study compares the effects of acute and chronic blood loss anemia on vascular function after myocardial infarction in mice, finding both types impair endothelial function with chronic anemia additionally reducing vascular smooth muscle contractility.

VERICIGUAT RESCUES cGMP PRODUCTION IN HUMAN AORTIC VASCULAR SMOOTH MUSCLE CELLS AND AUGMENTS VASORELAXATION IN AORTIC RINGS EXPOSED TO HIGH GLUCOSE

Morphological evaluation of rat cerebellum following administration of nitrogen monoxide precursor and inhibitor

This study evaluates the histopathological effects of nitrogen monoxide on rat cerebellum through drug administration and histological analysis.

Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia

The paper shows astrocytes produce nitric oxide from nitrite via mitochondrial sulfite oxidase during hypoxia, modulating cerebral blood flow.

Effect of nitrite on neural activity in the healthy brain

This study investigates the effects of nitrite on neural activity in healthy individuals and finds no significant changes in EEG power spectra, suggesting nitrite's effects are specific to hypoxic conditions.