Pain Mechanisms and Treatments

The paper shows that female human nociceptors are sensitized by prolactin, indicating a female-selective pain mechanism.

The paper shows that MNK inhibitor eFT508 reduces spontaneous activity in human DRG neurons from painful dermatomes.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

This study investigates the sex-specific role of AUF1 in modulating gene expression and hypersensitivity after repeated ischemia-reperfusion injury in mice.

The paper analyzes bulk RNA-seq data from murine dorsal root ganglia neurons after nerve injury to identify sex-specific transcriptional changes across neuronal subtypes.

This study shows that CDK5 activation in human sensory neurons broadens action potentials, suggesting a role in chronic pain mechanisms.

This study shows that layer 5 and 6 neurons in the primary somatosensory cortex modulate sensory gain and nociceptive behavior in opposite ways.

This study investigates the distinct roles of Aβ low-threshold mechanoreceptors in mechanical pain transmission, finding they have both local and global functions in hyperalgesia.

This study shows that the insulin receptor regulates persistent mechanical nociceptive sensitization in both flies and mice, independent of metabolic effects.

This study identifies SARS-CoV-2-induced transcriptomic changes in sensory tissues that correlate with time-dependent hypersensitivity in hamsters.

The paper identifies a GABAergic pathway from the RVM to the spinal dorsal horn that mediates bilateral antinociception and is involved in pain control.

The paper identifies distinct neuron types in the vlPAG based on intrinsic firing patterns and shows that persistent inflammation selectively activates Phasic neurons, which are not defined by mu-opioid receptor expression.

This study shows that neutrophils infiltrate sensory ganglia and contribute to chronic widespread pain in fibromyalgia by conferring mechanical hypersensitivity in mice.

This study shows that norepinephrine transients in the parabrachial nucleus, induced by cNTScat input, amplify PB activity and sensory afferent responses in mice.

This study compares the effects of different treadmill running intensities on pain perception and endogenous pain modulation, finding that moderate and low intensity running induces stronger and longer-lasting hypoalgesia than high intensity running.

This study shows ASIC1a/ASIC2 channels in spinal neurons contribute to pain processing by modulating windup through calcium-dependent mechanisms.

This study examines sex-specific changes in neuroinflammation in spinal cord pain pathways following neonatal inflammation in rats.

This study investigates cognitive function in rats with OA-like knee pain and finds no evidence of cognitive impairment.

This study shows that neonatal injury increases microglial phagocytosis of GABAergic synapses in the spinal dorsal horn, leading to long-term structural changes and altered responses to adult re-injury.

This study shows that NPY-expressing inhibitory interneurons in the spinal dorsal horn reduce pain and itch behaviors, suggesting they are potential targets for treating pathological pain and itch.

This study shows Cannabis terpenes reduce chronic neuropathic pain in mice by activating spinal cord adenosine A2A receptors, with efficacy comparable to morphine.

This study identifies a glutamatergic pathway from VGluT3DRN to DAVTA that modulates neuropathic pain and depression-like behavior through DA release in the NAcMed.

This study demonstrates the efficacy of a humanised chemogenetic system in silencing sensory neuron hyperexcitability and reducing pain in both mouse and human models.

This study shows that inhibiting FLT3 signaling preserves opioid analgesia while preventing tolerance and hyperalgesia in chronic pain models.

This study shows that hIAPP aggregation causes peripheral neuropathy in mice and is associated with reduced IENF density and increased hIAPP oligomers in T2DM patients.

This study identifies a calcium-dependent mechanism that modulates spinal dorsal horn PVINs' electrical activity after nerve injury, showing that impaired calcium buffering increases SK channel activity and reduces intrinsic excitability.

This paper develops AAV-delivered dimeric peptide inhibitors of PICK1 to alleviate neuropathic pain in mice, showing long-term relief without adverse effects.

This study identifies the left dorsal anterior insula as a region coding pain prediction error adaptively, responding to unexpected pain and contextual information.

This study shows that macrophage epigenetic changes from early life injury influence pain responses later in life, with a focus on sex-specific effects.