Pregnancy and preeclampsia studies

Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats - A promising natural therapeutic agent for hypertensive disorders of pregnancy

This study shows eugenol has potent vasorelaxant effects in uterine arteries from pregnant goats, with TRPV1-mediated action and enhanced effect during pregnancy.

Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia

This study identifies lipidomic changes in maternal blood linked to severe preeclampsia, showing altered lipid species and their potential as biomarkers.

Atypical Protein Kinase C iota (PKC{lambda}/{iota}) Ensures Mammalian Development by Establishing the Maternal-Fetal Exchange Interface

This study identifies PKCλ/ι as essential for trophoblast progenitor differentiation into syncytiotrophoblast cells during placentation in both mice and humans.

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of Preeclampsia

This study identifies epigenetic reprogramming defects in preeclampsia placenta that cause developmental delay and can be detected in serum cfDNA for early prediction.

Landscape of Dysregulated Placental RNA Editing Associated with Preeclampsia

The paper identifies widespread RNA editing dysregulation in placental tissue from preeclampsia patients and links it to altered LEP expression and disease pathogenesis.

Overlapping Pathogenic Signalling Pathways and Biomarkers in Preeclampsia and Cardiovascular Disease

This paper identifies 76 common biomarkers and 29 shared pathways between preeclampsia, hypertension, and HFpEF using in silico analysis of public datasets.

Risk of preeclampsia in patients with genetic predisposition to common medical conditions: a case-control study

This study investigates whether genetic predisposition to medical conditions linked to preeclampsia risk increases preeclampsia risk, finding associations with diastolic blood pressure and BMI.

Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia

This study identifies changes in pregnancy-related serum biomarkers early in gestation as indicators of later preeclampsia development, validated in both human and mouse models.

Distinct molecular processes in placentae involved in two major subtypes of preeclampsia

The paper identifies distinct molecular features in placenta samples from early-onset and late-onset severe preeclampsia, suggesting different underlying mechanisms.

Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus

This study investigates the distinct roles of fetal and trophoblast PI3Kp110α in regulating nutrient supply to the fetus, showing differential effects on placental function and fetal growth.

Low oxygen enhances trophoblast column growth by potentiating the extravillous lineage and promoting LOX activity

This study shows low oxygen promotes extravillous trophoblast differentiation in a human placental explant model by enhancing EVT lineage commitment and LOX activity.

Maternal Circulating MiRNAs That Predict Infant FASD Outcomes Influence Placental Maturation

The paper identifies maternal circulating miRNAs that predict infant FASD outcomes and show they impair placental development by inhibiting the EMT pathway in trophoblasts.

sFlt-1 commutes unfolded protein response into endoplasmic reticulum stress in trophoblast cells in preeclamptic pregnancies

The paper shows that sFlt-1 from preeclamptic pregnancies induces endoplasmic reticulum stress in trophoblast cells through increased expression of ER stress markers.

Down-regulated Long Noncoding RNA HOXA11-AS affects trophoblast cell proliferation and migration by regulating RND3 and HOXA7 expression in preeclampsia

This study shows that downregulated HOXA11-AS in preeclampsia affects trophoblast proliferation and migration by regulating RND3 and HOXA7 through Ezh2/Lsd1 and miR-15b-5p mechanisms.

Creation of gene expression database on preeclampsia-affected human placenta

The paper creates a gene expression database of preeclampsia-affected human placenta by processing and standardizing 33 datasets to improve analysis accuracy.

sFlt-1 (sVEGFR1) induces placental endoplasmic reticulum stress in trophoblast cell: implications for the complications in preeclampsia - an in vitro study

This study shows that sFlt-1 increases ER stress markers in trophoblast cells, linking it to preeclampsia complications.

The value of DNA methylation profiling in characterizing preeclampsia and intrauterine growth restriction

This study identifies DNA methylation changes in early-onset preeclampsia, late-onset preeclampsia, and normotensive intrauterine growth restriction, revealing distinct methylation clusters and potential clinical subgroups.

The Core Transcriptome Of Mammalian Placentas And The Divergence Of Expression With Placental Shape

The paper identifies 115 core genes expressed in all eutherian placentas and finds genes associated with placental shape and pre-eclampsia.

The depletion of MARVELD1 leads to placenta accreta via integrin β4-dependent trophoblast cell invasion

This study shows that MARVELD1 depletion causes placenta accreta by increasing trophoblast invasion through integrin β4 regulation in mice.