Pregnancy and preeclampsia studies

Abnormal trophoblast invasion in early onset preeclampsia: involvement of cystathionine β-synthase, specificity protein 1 and miR-22

The paper compares MMPs, TIMPs, CBS, Sp1, and miR-22 expression in EOPE patients and controls, finding significant downregulation of MMPs, CBS, and Sp1 and upregulation of TIMPs and miR-22.

Role of MicroRNA-22 (miR-22)/Specificity protein 1 (Sp1)/Cystathionine beta-synthase (CBS) axis in regulating trophoblast invasion: an in vitro study

This study investigates the miR-22/Sp1/CBS axis in regulating trophoblast invasion using in vitro experiments with HTR-8/SVneo cells.

MicroRNA-22, Specificity protein-1 and Cystathionine β-synthase in early onset Preeclampsia: significance in trophoblast invasion

The paper investigates the expression levels of MMPs 2, 9, TIMPs 1, 2, CBS, Sp1, and miR-22 in early onset preeclampsia and normotensive controls, finding reduced MMPs and CBS/Sp1 with increased TIMPs and miR-22 in preeclamptic patients.

Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.

CITED2 is a Conserved Regulator of the Uterine-Placental Interface

This study investigates the role of CITED2 in regulating the uterine-placental interface in rat and human models, showing its critical role in trophoblast cell development and placental function.

AKT1-FOXO4 AXIS RECIPROACLLY REGULATES HEMOCHORIAL PLACENTATION

The paper uses genome-edited rat models to show AKT1 and FOXO4 reciprocally regulate hemochorial placenta development.

HAND1 knockdown disrupts trophoblast global gene expression

This study shows that HAND1 knockdown affects gene expression in trophoblast cells but not endothelial cells, highlighting the importance of extra-embryonic tissue in CHD research.

Urinary proteome changes during pregnancy in rats

The paper analyzes urinary proteome changes in pregnant rats to identify pregnancy-related physiological and developmental processes.

Identifying novel regulators of placental development using time series transcriptomic data and network analyses

This study identifies novel regulators of placental development by analyzing time series RNA-seq data and gene interaction networks in mouse fetal placenta.

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy

This study creates a spatially resolved single-cell multiomics atlas of human trophoblast differentiation in early pregnancy, revealing key regulatory programs and cell-cell communication events involved in EVT invasion and arterial transformation.

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

The paper identifies a disrupted trophoblast transition in preeclampsia, linking placental pathology to maternal syndrome through multi-omics profiling and in vitro analyses.

Conservation at the uterine-placental interface

This study identifies conserved transcriptomic features of invasive trophoblast cells in rat and human placentation, providing insights into shared regulatory mechanisms essential for healthy pregnancy.

RACK1 may participate in placental development via regulating proliferation and migration of trophoblast cell in pigs following intrauterine growth restriction

The paper investigates placental development in pigs with IUGR, identifying RACK1 as a regulator of trophoblast proliferation and migration affecting placental fold formation.

Hippo Signaling Cofactor, WWTR1, at the Crossroads of Human Trophoblast Progenitor Self-Renewal and Differentiation.

This study identifies WWTR1 as a master regulator of human trophoblast progenitor self-renewal and differentiation, showing its role in promoting EVT differentiation and preventing STB fate.

Endothelial Dnmt3a controls placenta vascularization and function to support fetal growth

This study shows that Dnmt3a regulates placental vascularization and fetal growth by controlling DNA methylation in endothelial cells, identifying it as a key factor in placental function.

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

The paper uses single-cell RNA sequencing to identify a novel cytotrophoblast population in the smooth chorion of the human placenta that functions as a barrier and restricts EVT invasion.

Loss of polarity regulators initiates gasdermin E mediated pyroptosis in human maternal fetal interface trophoblasts

The paper shows that loss of aPKC activity in trophoblasts leads to gasdermin E-mediated pyroptosis, linking polarity regulators to inflammation in the maternal-fetal interface.

Clotting factor genes are associated with preeclampsia in high altitude pregnant women in the Peruvian Andes

This study identifies clotting factor genes PROZ, F7, and F10 on chromosome 13 as associated with preeclampsia in high-altitude Andean families.

Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

This study shows VE-cadherin is essential for trophoblast migration and spiral artery remodeling in mouse placental development, revealing a non-endothelial role for this protein in vascular mimicry.

Protein-protein interaction map in pre-eclampsia through the interaction of hub genes, transcription factors and microRNAs

The paper constructs a protein-protein interaction map in pre-eclampsia by identifying hub genes, transcription factors, and microRNAs involved in disease mechanisms.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

This study shows that the imprinted Igf2-Igf2r axis is essential for coordinating placental microvasculature expansion with fetal growth in mice.

Identifying target sites for placental therapeutics through the comparison of normal term pregnancies and intrauterine growth restricted proteomes

The paper identifies potential targeting moieties for placental therapeutics by comparing proteomes of normal and intrauterine growth restricted placentas.

PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta

This study shows that disrupting the viral aspartic protease domain in PEG10 causes placental abnormalities and perinatal lethality in mice.

Placental gene expression-based cell type deconvolution: Cell proportions drive preeclampsia gene expression differences

The paper deconvolves placental gene expression data to show cell type proportions drive preeclampsia gene expression differences, reducing differentially expressed genes after adjustment.

Placental structure, function and mitochondrial phenotype relate to fetal size and sex in mice

The paper examines how placental mitochondrial function and structure differ between lightest and heaviest fetuses in mice, with sex-specific effects on gene expression and metabolic pathways.

Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation

The paper compares transcriptomes of human and rhesus placenta, identifies differentially expressed genes, and develops novel rhesus trophoblast cell lines for studying placentation.

Variation in Placental microRNA Expression Associates with Familial Cardiovascular Disease

The paper identifies microRNAs in placental tissue associated with familial cardiovascular disease using RNA sequencing and statistical modeling.

Evidence, evolution and pattern of contractile elements in villous vascular walls and stroma of human placentas of premature infants of different gestational ages. An immuno-morphologic comparative study.

The paper examines contractile elements in placental villi of premature and term infants, finding persistent SMA and desmin expression in vascular walls and stroma across gestational ages.

LncRNA H19X is required for placenta development and angiogenesis through regulating a noncoding RNA regulatory network

This study shows that H19X lncRNA regulates placental development and angiogenesis by interacting with miR-424/miR-503, PIWIL1, and HIF-1A/HIF-2A under hypoxia.

Maternal-Fetal Genetic Interactions, Imprinting, and Risk of Placental Abruption

This study identifies maternal-fetal genetic interactions and imprinting effects associated with placental abruption risk using a large cohort of Peruvian mother-infant pairs.