Gastrointestinal motility and disorders

Identification of arginine-vasopressin receptor 1a (Avpr1a/AVPR1A) as a novel candidate gene for chronic visceral pain.

The paper identifies Avpr1a as a novel candidate gene for chronic visceral pain through genomic and functional analyses in mouse models and human patients.

Loss of ASD-Related Molecule Cntnap2 Affects Colonic Motility in Mice

This study investigates the role of Cntnap2 in GI motility using Cntnap2 mutant mice, finding altered colonic motility without affecting ENS organization.

Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus

This study compares three wholemount dissection methods for neuronal subtype markers in the mouse myenteric plexus, finding that one method reduces marker labeling.

Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

The paper identifies spontaneous neurogenic GI motility in ex vivo assays and links it to cholinergic signaling in enteric nervous system development.

PIEZO2 in somatosensory neurons controls gastrointestinal transit

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

Altered secretion, constitution, and functional properties of the gastrointestinal mucus in a rat model of sporadic Alzheimer's disease

This study investigates how central Alzheimer's pathology affects gastrointestinal mucus function in a rat model, finding altered secretion, composition, and barrier properties.

Neural indicators of human gut feelings

This study investigates neural responses to gastrointestinal sensations using a vibrating capsule, showing improved perceptual accuracy and correlated neural activity.

Specialized enteric glial cells coordinate intestinal motility

The paper identifies specialized enteric glial cell subtypes in the mouse duodenum using single nucleus RNA-sequencing and spatial transcriptomics, showing one subtype's role in sensing force via PIEZO2 and its impact on gut motility.

Prox2+ and Runx3+ neurons regulate esophageal motility

The paper identifies and characterizes Prox2+ and Runx3+ vagal sensory neurons and shows their essential roles in esophageal peristalsis and swallowing.

Perinatal High Fat Diet Exposure Alters Oxytocin and Corticotropin Releasing Factor Inputs onto Vagal Neurocircuits Controlling Gastric Motility

This study shows that perinatal high fat diet exposure reduces oxytocin inputs and increases corticotropin releasing factor inputs to vagal neurocircuits, leading to altered gastric motility and stress responses.

Anesthesia suppresses gastric myoelectric power in the ferret

This study shows that general anesthesia reduces gastric myoelectric power in ferrets and that behavioral movement increases signal power compared to rest.

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

This study identifies 38 new genetic loci for irritable bowel syndrome through a multi-trait genome-wide association analysis, revealing genetic overlaps with mental conditions and potential causal relationships.

Comparative transcriptomics reveal highly conserved regional programs between porcine and human colonic enteric nervous system

This study compares transcriptomic profiles of porcine and human colonic enteric nervous system to identify conserved regional programs and their response to vagal nerve stimulation.

The vagus nerve mediates the stomach-brain coherence in rats

This study investigates stomach-brain coherence in rats using fMRI and gastric slow wave recordings, finding that vagus nerve activity mediates this coherence, which varies between fasting and fed states.

Regional cytoarchitecture of the adult and developing mouse enteric nervous system

The paper demonstrates that the enteric nervous system is organized into circumferential stripes with regionally distinct development and neuronal composition.

Anatomical and functional maturation of the mid-gestation human intestine

This study examines anatomical and functional maturation of the human fetal intestine, identifying when the enteric nervous system becomes functionally active.

High-Resolution Ultrasound and Speckle Tracking: a non-invasive approach to assess in vivo gastrointestinal motility during development

This study uses high-resolution ultrasound and speckle tracking to visualize and quantify fetal gastrointestinal motility in chick embryos, showing synchronized contractions develop late in fetal life.

Enteric glial cells of the two plexi of the enteric nervous system exhibit phenotypic and functional inter-and intra-heterogeneity

This study develops a method to culture enteric glial cells (EGC) from inner and outer gut layers, revealing phenotypic and functional differences between them.

Caecal dysfunction in the NL3R451C mouse model of autism

This study investigates caecal dysfunction in NL3R451C mice, a model of autism, finding altered motility patterns and reduced secretion in response to a nicotinic agonist.

Newly raised anti-c-Kit antibody detects interstitial cells of Cajal in the gut of chicken embryos

This paper develops a new anti-c-Kit antibody to identify interstitial cells of Cajal in chicken embryos and demonstrates its utility in visualizing ICCs in different gut layers.

Sex differences in pain-related behaviors and clinical progression of disease in mouse models of visceral pain

This study examines sex differences in visceral pain behaviors and disease progression in mouse models of acute and persistent colon inflammation, finding sex-specific responses and disease outcomes.

Distribution map of peristaltic waves in the chicken embryonic gut reveals importance of ENS and inter-region cross talks along the gut axis

The paper maps peristaltic wave origins along the chicken embryonic gut axis, revealing ENS regulation and inter-region cross-talk in gut development.

Engaging Biological Oscillators through Second Messenger Pathways Permits Emergence of a Robust Gastric Slow-Wave during Peristalsis

The paper develops a computational model of gastric motility to show how second messenger exchange between interstitial cells of Cajal ensures robust entrained slow-wave propagation during peristalsis.

Androgen regulation of bowel function in mice and humans

This study shows androgens regulate colonic motility in mice and humans, with lower testosterone levels linked to IBS symptom severity.

Gastric Neurons in the Nucleus Tractus Solitarius are Selective to the Orientation of Gastric Electrical Stimulation

The paper investigates how gastric electrical stimulation (GES) orientation affects neural responses in the nucleus tractus solitarius (NTS) in rats, finding orientation-specific activation of gastric neurons.

Enteric glial cells respond to a dietary change in the lamina propria in a MyD88-dependent manner

This study shows that enteric glial cells respond to a high-fat diet through MyD88-dependent mechanisms, influencing metabolic outcomes in mice.

Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrinergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice

This study shows that intestinal bacteria maintain adult enteric neurons via TLR2-induced neurogenesis in mice, with implications for treating colonic motility disorders.

Microbiota-modulated enteric neuron translational profiling uncovers a CART+ glucoregulatory subset

The paper identifies a microbiota-influenced subset of enteric neurons that regulate glucose levels through insulin signaling.

Neuronal programming by microbiota enables environmental regulation of intestinal motility

The paper shows microbiota induce AhR in enteric neurons, enabling them to respond to environmental signals.

Machine learning prediction of emesis and gastrointestinal state in ferrets

This study uses machine learning to predict emesis and gastrointestinal states in ferrets using implanted myoelectric signals.