Cannabis and Cannabinoid Research

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.

This study evaluates CB-13, a peripherally selective CB1 agonist, showing it reduces pain in mice but develops tolerance and CNS effects with repeated dosing.

The paper tests a CB1 receptor NAM, RTICBM-74, showing it reduces alcohol intake in rats without affecting locomotion or sucrose self-administration.

This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.

This study investigates the mechanisms of 2-AG mobilization in the dorsal lateral striatum following synaptic stimulation, revealing the roles of glutamatergic and cholinergic neurotransmission.

This study examines how cannabis vapour with THC or balanced THC:CBD affects oscillatory activity in a schizophrenia model, finding THC suppresses activity while CBD balances its effects.

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

The paper examines how genetic and epigenetic factors at AKT1 rs1130233 modulate THC-induced brain activation during fear processing in healthy males.

This study shows that NIDA-produced Cannabis sativa lacks genetic diversity compared to state market varieties, limiting the generalizability of research findings.

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

The paper assesses the genetic and chemical consistency of CBD hemp accessions, finding significant variability and reliability issues in commercial varieties.

The paper predicts essential binding domains of AEA in the CB1 receptor using molecular dynamics simulations, identifying the hydrophobic channel and H2/H3 region as critical for AEA binding.

This study shows that cnr2 is critical for ribbon synapse maturation and function in hair cells and photoreceptors, affecting synaptic structure and behavior in zebrafish larvae.

This study shows that endocannabinoids and dopamine interact to modulate long-term plasticity in the entopeduncular nucleus, influencing the balance of direct and indirect output dominance.

This study shows that hepatic CB1R regulates soluble leptin receptor (sOb-R) levels through CHOP, contributing to leptin resistance in diet-induced obesity.

This study shows that CB1 receptor deletion affects cerebellar learning indirectly through altered behavioral state rather than direct synaptic plasticity effects.

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.

This study investigates how the cannabinoid agonist CP-55,940 affects sign-tracking and goal-tracking behaviors in rats, finding that it decreases sign-tracking and increases goal-tracking in a dose-dependent manner.

This study shows that THC exposure via lactation during early postnatal life leads to lasting behavioral and synaptic deficits in adult rats.

This study examines how early-life stress affects cerebellar endocannabinoid levels and behavior, revealing sex-specific differences and potential contributions to brain sexual differentiation.

This study examines whether cannabis use extent predicts psychotic-like and euphoric intoxication experiences in First Episode Psychosis patients and controls, finding a significant interaction between caseness and use frequency.

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.

This study shows that vaporized THC-rich cannabis extracts reinforce behavior and increase drug-seeking in rats, supporting their use as a preclinical model for cannabis research.

This study shows chronic cannabis users show reduced reward system responsiveness to cannabis, leading to tolerance to its impairing effects.

The paper examines synaptic connectivity and plasticity in the adult mouse nucleus accumbens core, revealing pathway- and cell-type specific contributions of BLA, PFC, and vHipp inputs, and the role of endocannabinoid receptors.

The paper examines phenotypic and genetic relationships between cannabis use, depression, and self-harm using UK Biobank and consortium data, finding associations and genetic correlations.